supported by a National Research Foundation of Korea(NRF)grant funded by the Korean Government,Ministry of Science and ICT(MSIT)(2016R1C1B102207,2022R1A2C1004141 and 2022R1A2C-1091712);the National R&D Program for Cancer Control through the National Cancer Center(NCC)funded by the Ministry of Health&Welfare,Republic of Korea(HA22C0053000022).
Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been established.In this study,we investigated whether Neural Wiskott-Aldrich syndr...
This work was supported by a grant from the Natural Science Foundation of China (No. 81601471).
The growth arrest-specific gene 7 (GAST), a member of the growth-arrest-specific family, encodes three protein isoforms (GAS7A, GAS7B, and GAS7C) and plays a potential role in lung cancer as a tumor suppressor gen...
We thank Professors Volker Haucke, Marc Kirschner, Alexander Sorisky and Jane Y Wu for constructs. We thank Yuan Lu and Zong-Fang Wan for excellent technical assistance. We thank Dr Qian Hu and ION Optical Imaging Core Facility for confocal microscopy and data analysis support, and Dr Min Jiang and IOBS-Nikon Biological Imaging Center for use of the N-SIM microscope. We are grateful to Drs Xueliang Zhu and Xiumin Yan, colleagues at ION, and members of the Yu laboratory for suggestions and comments. This work was supported by the National Natural Science Foundation of China (31321091 and 31530030), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02010000) and the Science and Technology Commission of Shanghai Municipality (16XD 1404800).
Neurite initiation is critical for neuronal morphogenesis and early neural circuit development. Recent studies showed that local actin aggregation underneath the cell membrane determined the site of neurite initiation...