ONCOPROTEIN

作品数：38被引量：145H指数：6
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相关领域：医药卫生生物学更多>>
相关作者：盛志勇孙同柱顾小曼杨银辉付小兵更多>>
相关机构：解放军总医院第一附属医院复旦大学泸州医学院潍坊医学院附属医院更多>>
相关期刊：《Chinese Medical Journal》《神经药理学报》《Frontiers of Medicine》《Cellular & Molecular Immunology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划王宽诚敎育基金北京市自然科学基金更多>>
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Oncoprotein LAMTOR5-mediated CHOP silence via DNA hypermethylation and miR-182/miR-769 in promotion of liver cancer growth被引量：1
《Acta Pharmacologica Sinica》2024年第12期2625-2645,共21页Xue Wang Qian-qian Li Yan-xin Tang Ye Li Lu Zhang Fei-fei Xu Xue-li Fu Kai Ye Jia-qi Ma Shi-man Guo Fang-yuan Ma Zhi-yu Liu Xu-he Shi Xian-meng Li Hui-min Sun Yue Wu Wei-ying Zhang Li-hong Ye 
supported by the National Natural Science Foundation of China(82072943 and 82072929).
C/EBP homologous protein(CHOP)triggers the death of multiple cancers via endoplasmic reticulum(ER)stress.However,the function and regulatory mechanism of CHOP in liver cancer remain elusive.We have reported that late ...
关键词：liver cancer CHOP LAMTOR5 lenvatinib DNA methylation miR-182/miR-769 
In silico prospective analysis of the medicinal plants activity on the CagA oncoprotein from Helicobacter pylori
《World Journal of Clinical Oncology》2024年第5期653-663,共11页Rafaela Viana Vieira Gabrielle Caroline Peiter Fabrício Freire de Melo Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira 
BACKGROUND Colonization with Helicobacter pylori(H.pylori)has a strong correlation with gastric cancer,and the virulence factor CagA is implicated in carcinogenesis.Studies have been conducted using medicinal plants w...
关键词：CagA oncoprotein Phenolic compounds Helicobacter pylori In silico analyses Medicinal plants Prospective analysis 
The next decade of SET:from an oncoprotein to beyond
《Journal of Molecular Cell Biology》2024年第1期1-14,共14页Han Yao Meng Zhang Donglai Wang 
supported by the National Natural ScienceFoundation of China(82073132,82122054,81872311,and82203340);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2021-I2M-1-016 and2022-I2M-JB-003);the Fundamental Research Funds for theCentral Universities(3332023147);the Overseas ExpertiseIntroduction Center for Discipline Innovation(‘111 Center’;BP0820029);the State Key Laboratory Special Fund(2060204).
This year marks the fourth decade of research into the protein SET,which was discovered in 1992.SET was initially identified as an oncoprotein but later shown to be a multifaceted protein involved in regulating numero...
关键词：SET biological process regulatory mechanism DISEASE THERAPY 
Immune response modulation in inflammatory bowel diseases by Helicobacter pylori infection被引量：3
《World Journal of Gastroenterology》2023年第30期4604-4615,共12页Gabriella Feilstrecker Balani Mariana dos Santos Cortez Jayme Euclydes Picasky da Silveira Freitas Fabrício Freire de Melo Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira 
Many studies point to an association between Helicobacter pylori(H.pylori)infection and inflammatory bowel diseases(IBD).Although controversial,this association indicates that the presence of the bacterium somehow aff...
关键词：Cytotoxin-associated antigen A oncoprotein Gut microbiota Helicobacter pylori Helicobacter pylori neutrophilactivating protein Immunological modulation Inflammatory bowel disease NLR family pyrin domain containing 3 inflammasome 
Hyperthermia promotes degradation of the acute promyelocytic leukemia driver oncoprotein ZBTB16/RARα被引量：1
《Acta Pharmacologica Sinica》2023年第4期822-831,共10页Qian-qian Wang Liaqat Hussain Pei-han Yu Chang Yang Chen-ying Zhu Ya-fang Ma Si-chun Wang Tao Yang Yuan-yuan Kang Wen-juan Yu Yasen Maimaitiyiming Hua Naranmandura 
supported by grants from the National Natural Science Foundation of China(No.81872942,82003875,82000155,82000145,82200160);the China Postdoctoral Science Foundation(No.2021M702875,2021M702877);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang,Grant/Award Number:2020R01006.
The acute promyelocytic leukemia(APL)driver ZBTB16/RARαis generated by the t(11;17)(q23;q21)chromosomal translocation,which is resistant to combined treatment of all-trans retinoic acid(ATRA)and arsenic trioxide(ATO)...
关键词：acute promyelocytic leukemia ZBTB16/RARαfusion protein HYPERTHERMIA PROTEOLYSIS nuclear receptor corepressors ARSENICALS 
A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy被引量：2
《Cell Research》2023年第1期55-70,共16页Zaizhou Liu Kaige Chen Jun Dai Peng Xu Wei Sun Wanlin Liu Zhixin Zhao Steven P.Bennett Peifeng Li Tiancheng Ma Yuqi Lin Akinori Kawakami Jing Yu Fei Wang Chunxi Wang Miao Li Peter Chase Peter Hodder Timothy P.Spicer Louis Scampavia Chunyang Cao Lifeng Pan Jiajia Dong Yong Chen Biao Yu Min Guo Pengfei Fang David E.Fisher Jing Wang 
The study is supported by the Lingang Laboratory(LG-QS-202205-11 to J.W.and W.S.);the National Natural Science Foundation of China(21977108 and 21778067 to J.W.,21778064 and 21977107 to P.F.,and 21621002 to B.Y.);the Shanghai Science and Technology Committee(20S11901100 to J.W.and 19411951700 to Y.C.);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB20000000 to J.W.,P.F.and B.Y.);One-hundred Talents Program of Chinese Academy of Sciences(to J.W.);the State Key Laboratory of Bioorganic and Natural Products Chemistry(to J.W.,P.F.and B.Y.);a 1000-talent young investigator award(to P.F.);the K.C.Wong Education Foundation(to B.Y.);NIH grants(GM100136 to M.G.,2P01 CA163222-06,5R01 AR043369-23,5R01CA222871-02 and 5R01AR072304-03 to D.E.F.);the Dr.Miriam and Sheldon G.Adelson Medical Research Foundation(to D.E.F.).The authors also gratefully acknowledge technical supports from Chemical Biology Core Facility at Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences;Fudan University Shanghai Cancer Center Laboratory Animal Science.The authors also grateful acknowledge Prof.Jun Wang for the support on the mice experiments and Dr.Tom Powell and Dr.Tamar Babilla Propp for expert assistance with paper preparation.
Microphthalmia transcription factor(MITF)regulates melanocyte development and is the“lineage-specific survival”oncogene of melanoma.MITF is essential for melanoma initiation,progression,and relapse and has been cons...
关键词：MELANOMA interface dynamic 
LATS1 K751 acetylation blocks activation of Hippo signalling and switches LATS1 from a tumor suppressor to an oncoprotein被引量：2
《Science China(Life Sciences)》2022年第1期129-141,共13页Siyuan Yang Weizhi Xu Cheng Liu Jiaqi Jin Xueying Li Yuhan Jiang Lei Zhang Xianbin Meng Jun Zhan Hongquan Zhang 
supported by the National Natural Science Foundation of China(81730071,81972616,81230051,81472734,31170711 and 81773199);the Ministry of Science and Technology of China(2016YFC1302103 and 2015CB553906);Beijing Natural Science Foundation(7120002 and 7171005);Peking University(BMU2018JC004,BMU20120314 and BMU20130364)。
Large tumor suppressor 1(LATS1)is the key kinase controlling activation of Hippo signalling pathway.Post-translational modifications of LATS1 modulate its kinase activity.However,detailed mechanism underlying LATS1 st...
关键词：LATS1 acetylation LATS1 activation and inhibition Hippo signalling pathway lung adenocarcinoma 
Suppression of human papillomavirus type 16 E5 oncoprotein:A promising step in fostering the treatment of cervical cancer被引量：1
《Oncology Research》2021年第2期141-148,共8页NIMA HEMMAT MOHAMMAD AMIN DOUSTVANDI ZAHRA ASADZADEH AHAD MOKHTARZADEH BEHZAD BARADARAN HOSSEIN BANNAZADEH BAGHI 
supported by a grant from Tabriz University of Medical Sciences(Tbzmed)(376 and 1397).
Cervical cancer is a growing global disease in developing countries.Persistent infection with human papillomaviruses(HPV)is an essential causative agent in this type of cancer.Several studies demonstrate HPV E5 oncopr...
关键词：Human papillomavirus e5 transforming protein epidermal growth factor receptor cervical cancer CASKI 
Oncoprotein HBXIP promotes tumorigenesis through MAPK/ERK pathway activation in non-small cell lung cancer被引量：4
《Cancer Biology & Medicine》2021年第1期105-119,共15页Jun Zhang Bei Sun Xianhui Ruan Xiukun Hou Jingtai Zhi Xiangrui Meng Xiangqian Zheng Ming Gao 
supported by the National Natural Science Foundation of China(Grant Nos.81502322,81872169,and 81702629);the Tianjin Key Research and Development Program of Science and Technology Support Key Projects(Grant No.17YFZCSY00690);the XI SI KE--CSPC Cancer Research Fund。
Objective:The oncoprotein,hepatitis B X-interacting protein(HBXIP),has been reported to play an important role in human malignancies.However,its functions in non-small cell lung cancer(NSCLC)are poorly understood.The ...
关键词：HBXIP non-small cell lung cancer MEK1 tumor progression 
Bunayaviruses hijack a plant multifunctional MYC oncoprotein to build mutalism between insect pests and insect-dispersed virus
《Science Foundation in China》2019年第3期36-36,共1页
With the support by the National Natural Science Foundation of China and the Chinese Academy of Sciences,the research team led by Prof Ye Jian(叶健)at the State Key Laboratory of Plant Genomics,Institute of Microbiolo...
关键词：dispersed journal mutual 
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