supported by grants from the National Natural Science Foundation of China(No.81872942,82003875,82000155,82000145,82200160);the China Postdoctoral Science Foundation(No.2021M702875,2021M702877);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang,Grant/Award Number:2020R01006.
The acute promyelocytic leukemia(APL)driver ZBTB16/RARαis generated by the t(11;17)(q23;q21)chromosomal translocation,which is resistant to combined treatment of all-trans retinoic acid(ATRA)and arsenic trioxide(ATO)...
sponsored by the National Natural Science Foundation of China (No. 91543103)
Arsenic(As) is a notoriously toxic pollutant of health concern worldwide with potential risk of cancer induction, but meanwhile it is used as medicines for the treatment of different conditions including hematologic...
supported by Alberta Health, Alberta Innovates, the Canada Research Chairs Program;the Canadian Institutes of Health Research (CIHR);the Natural Sciences and Engineering Research Council (NSERC) of Canada
The occurrence of a large number of diverse arsenic species in the environment and in biological systems makes it important to compare their relative toxicity. The toxicity of arsenic species has been examined in vari...
The benzenearsonate, Roxarsone, has been used since 1944 as an antimicrobial, growth-promoting poultry feed additive. USGS and EPA report that Roxarsone (4-hydroxy-3-nitrobenzenearsonate) and metabolites, including AH...
Arsenic trioxide (As2O3) has been used medicinally for thousands of years. Its therapeutic use in leukaemia was described a century ago. Recent rekindling in the interest of As2O3 is due to its high efficacy in acut...
the Science Foundation of Shaanxi Province (No. 2001-KG9).
cDNA microarray was used to compare the gene expression profiles of multiple myeloma cell line RPMI8226 24 h before and after treatment with arsenic trioxide. Two cDNA probes were prepared by mRNA reverse transcriptio...
Arsenic trioxide (ATO) can induce cellular apoptosis ,and inhibit the activities of multiple myeloma (MM)cells in vitro, but how it works is not very clear. Recent studies showed that ATO worked on the voltagedepe...
supported by the National Natural Science Foundation of China(Grant No.30370507);the Key Projects Foundation of Harbin Science and Technology Commission(Grant No.2003AA9CS188-12).
Arsenic trioxide (As2O3) is very effective for treatment of acute promyelocytic leukaemia (APL) but little can pass through the blood-brain-barrier (BBB),which limits its use in the prevention and treatment of central...