supported by the National Natural Science Foundation of China(No.31972821);the General Scientific Research Project of Education of Zhejiang Province,China(No.422204123);the Starting Research Fund of Ningbo University,Zhejiang,China(No.421912073).
Lysine-specific demethylase 4 A(KDM4A,also named JMJD2A,KIA0677,or JHDM3A)is a demethylase that can remove methyl groups from histones H3K9me2/3,H3K36me2/3,and H1.4K26me2/me3.Accumulating evidence suggests that KDM4A ...
supported by the National Key Research & Development Program of China (2017YFA0503900);National Natural Science Foundation of China (31701099, 81621063, 81530074, 31570812, and 81720108027);Science and Technology Program of Guangdong Province in China (2017B030301016);Science and Technology Foundation of Shenzhen City (JCYJ20170302144650949 and JCY20170818094707964);Shenzhen Peacock Plan;the Shenzhen Municipal Commission of Science and Technology Innovation (JCYJ20160427104855100 and JCYJ20170818092450901);Natural Science Foundation of Guangdong Province (2017A030310459);Natural Science Foundation of SZU (2017085)
Dear Editor, Chromatin is the macromolecular complex of DNA and histone proteins, which provides the scaffold for the packaging of our entire genome. In the basic unit of chromatin, the nucleosomes contain 147 base pa...
Histone lysine methylation can be removed by JmjC domain-containing proteins in a sequence- and methylationstate-specific manner. However, how substrate specificity is determined and how the enzymes are regulated were...
H3K9me2 and H3K27me2 are important epigenetic marks associated with transcription repression, while H3K4me3 is associated with transcription activation. It has been shown that active and repressive histone methylation...