No.B2010033 Scientific Research Foundation,Health Department,Hunan Province
Objectives:To investigate the effects of adenovirus-mediated inducible nitric oxide synthase gene transfection on bladder transitional cell carcinoma T24 cells,and to provide novel insights and approaches to clinical...
supported by the National Natural Science Foundation of China(No.30900730);the grants from the Natural Science Foundation of Shangdong Province(No.Q2007D01)
Objective:To generate recombinant adenovirus that could simultaneously express ornithine decarboxylase(ODC) and S-adenosylmethionine decarboxylase(AdoMetDC) antisenses specifically in prostate cancer cells,and ev...
This project was supported by the National Natural Science Foundation of China (No. 30371386); by a grant from the Natural Science Foundation of Guangdong Province (No. 31010).
Objective: To investigate the therapeutic efficacy of adenovirus-mediated herpes simplex virus thymidine kinase (HSV-tk) gene transfer under the driving of KDR promoter (AdKDR-tk) in combination of ganciclovir (...
This work was supported by the NationalNatural Science Foundation of China (No. 39889916), theNational "973" Program of China (No. G2000057002), theNatural Science Foundation of Beijing (No. 7002009)Peking University Human Disease Center Project(2000-A-28) and Grant (No.1998-10).
Objective: To develop an adenovirus system to deliver biologically active peptides or proteins such as angiogenesis inhibitors in vivo for the treatment of cancer. Methods: DNA recombination techniques were employed...
This work was supported by the National Natural Foundation of China (No. 39670234 )
Objective: To evaluate the effect of adenovirus-mediated p53 gene (Adp53) on apoptosis andradiosensitivity of human gastric carcinoma cell lines.Methods: Recombinant adenovirus expressing wild-type p53 gene was transf...
This work was supported by a grant from the Science Foundation of National Committee of Education of China (No. 96361017).
Objective: To observe the synergistic efficacy between Adenovirus-mediated bcl-Xs(Adv-bcl-Xs) gene transfer and chemotherapy on ovarian cancer cell growth. Methods: NuTu-19 cells were infected by different titers of A...
National Natural Science Foundation of China (No. 39970689) and Natural Science Foundation of Shanghai (No. 99QB14047).
Objective: Interleukin 18 (IL-18) is a strong activator of NK cells and promotes the generation of IL-2, IFN-γ and GM-CSF. In the present study, we constructed adenovirus encoding IL-18 gene (AdIL-18), and observed t...
Objective: In most laryngeal cancers, the function of p53 gene is down regulated. To explore the potential use of p53 in gene therapy of laryngeal cancer, by introducing wild-type p53 into laryngeal cancer cell line v...
Objective: To study the growth suppression of lung adenocarcinoma cell by the introduction of wild type P53 gene and explore a gene therapy approach for lung adenocarcinoma. Methods: A replication deficient adeno v...