NOV

作品数:326被引量:803H指数:13
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相关领域:生物学更多>>
相关作者:苏炳银蔡文琴李巍李成仁张成岗更多>>
相关机构:第三军医大学中国科学院深圳市你我网络科技有限公司中国科学院南京地质古生物研究所更多>>
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Experimental study of a novel mouse model of tibial shaft fracture combined with blunt chest trauma
《Animal Models and Experimental Medicine》2025年第4期696-706,共11页Bing Zhang Tingting Fu Yi Han Gongke Li Xianyao Wan Yong Li 
This study was supported by Development Project of Key Laboratory of Big Data Analysis and Knowledge Service of Science and Technology Innovation Platform of Yangzhou-Yangzhou University Cooperation,Grant/Award Number:YBK202204;Jiangsu Province 333 High-level Talent.Training Project,Grant/Award Number:BRA2020176。
Backgroud:Thoracic Trauma and Limb Fractures Are the Two most Common Injuries in Multiple Trauma.However,there Is Still a Lack of Mouse Models of Trauma Combining Tibial Shaft Fracture(TSF)and Thoracic Trauma.In this ...
关键词:animal model CYTOKINES MICROIMAGING multiple trauma pulmonary contusion 
高效液相色谱-串联质谱法测定豚鼠血浆中的合成辣椒素
《分析试验室》2025年第1期83-88,共6页张倩 李海芸 张泗达 陈东 徐建富 张瑞华 
国民核生化灾害防护国家重点实验室基金(SKLNBC2021-11)资助。
建立了高效液相色谱-串联质谱(HPLC-MS/MS)测定豚鼠血浆中痕量合成辣椒素(NOV)的方法。以天然辣椒素(CAP)为内标,血浆样品经乙腈沉淀蛋白、高速离心、真空干燥浓缩、流动相复溶,制备待检样品。采用Agilent EclipsePlus C18色谱柱(2.1 mm...
关键词:高效液相色谱-串联质谱(HPLC-MS/MS) 豚鼠血浆 合成辣椒素(NOV) 天然辣椒素(CAP) 
Role of sphingolipid metabolism signaling in a novel mouse model of renal osteodystrophy based on transcriptomic approach
《Chinese Medical Journal》2025年第1期68-78,共11页Yujia Wang Yan Di Yongqi Li Jing Lu Bofan Ji Yuxia Zhang Zhiqing Chen Sijie Chen Bicheng Liu Rining Tang 
funded by the National Natural Science Foundation of China(No.82370742);the Key Program of Jiangsu Health and Health Committee(No.ZD2022045).
Background:Renal osteodystrophy(ROD)is a skeletal pathology associated with chronic kidney disease-mineral and bone disorder(CKD-MBD)that is characterized by aberrant bone mineralization and remodeling.ROD increases t...
关键词:Chronic kidney disease-mineral and bone disorder Renal osteodystrophy ADENINE PHOSPHATE TRANSCRIPTOMICS SPHINGOLIPIDS 
中晚期孕妇血清NOV/CCN3水平变化及其与妊娠期糖尿病、妊娠结局的关系
《实用医学杂志》2025年第1期71-77,共7页郑文静 储祥玲 吴雨琼 张敏 储小宏 张楠 胡红琳 
安徽省科技厅公益性联动基金项目(编号:1704F0804026)。
目的探讨中晚期孕妇血清NOV/CCN3水平变化,并分析其与妊娠期糖尿病(gestational diabetes mellitus,GDM)及妊娠结局的关系。方法根据口服葡萄糖耐量实验(oral glucose tolerance test,OGTT)结果,将252例妊娠女性分为GDM组与对照组。根...
关键词:妊娠期糖尿病 NOV/CCN3 妊娠结局 胰岛素抵抗 肥胖 
GAPDH suppresses adenovirus-induced oxidative stress and enables a superfast production of recombinant adenovirus
《Genes & Diseases》2024年第6期367-380,共14页Guozhi Zhao Piao Zhao Yonghui Wang Hui Zhang Yi Zhu Jiamin Zhong Wulin You Guowei Shen Changi Luo Ou Mei Xingye Wu Jingjing Li Yi Shu Hongwei Wang Wiliam Wagstaff Hue HLuu Yang Bi Lewis LShi Russell RReid Tong-Chuan He Li Jiang Wei Tang Jiaming Fan Ziwei Tang 
supported in part by research grants from the Natural Science Foundation of China (No.82000744 to ZT,and 82102696 to J.F.);the Chongqing Bayu Young Scholar Award (China) (to J.F.);the 2019 Funding for Postdoctoral Research (Chongqing Human Resources and Social Security Bureau of China) (No.298 to J.F.);the National Institutes of Health (No.CA226303 to T.C.H.,DE030480 to R.R.R.);supported by the Medical Scientist Training Program of the National Institutes of Health (USA) (No.T32 GM007281);supported in part by The University of Chicago Cancer Center Support Grant (No.P30CA014599);the National Center for Advancing Translational Sciences of the National Institutes of Health through grant number 2UL1TR002389-06 that funds the Institute for Translational Medicine (ITM);supported by the Mabel Green Myers Research Endowment Fund and The University of Chicago Orthopaedics Alumni Fund.
Recombinant adenovirus(rAdV)is a commonly used vector system for gene transfer.Efficient initial packaging and subsequent production of rAdV remains time-consuming and labor-intensive,possibly attributable to rAdv inf...
关键词:GAPDH GENETHERAPY Oxidative stress Packaging cell line Reactive oxygen species Recombinant adenovirus 
Optimal Multi-Timescale Scheduling of Integrated Energy Systems with Hybrid Energy Storage System Based on Lyapunov Optimization
《Journal of Beijing Institute of Technology》2024年第5期465-480,共16页Yehui Ma Dong Han Zhuoxin Lu 
supported by the National Natural Science Foundation of China(No.12171145)。
The economic operation of integrated energy system(IES)faces new challenges such as multi-timescale characteristics of heterogeneous energy sources,and cooperative operation of hybrid energy storage system(HESS).To th...
关键词:integrated energy systems multiple time scales hybrid energy storage systems Lya-punov optimization 
A quadrivalent norovirus vaccine based on a chimpanzee adenovirus vector induces potent immunity in mice
《Virologica Sinica》2024年第4期675-684,共10页Yihua Jiang Lingjin Sun Nan Qiao Xiang Wang Caihong Zhu Man Xing Hui Liu Ping Zhou Dongming Zhou 
supported by the National Natural Science Foundation of China(82241065,32070926)to D.Z.;the Sichuan Science and Technology Program(2023JDRC0090)to H.L.
Norovirus(NoV)infection is a major cause of gastroenteritis worldwide.The virus poses great challenges in developing vaccines with broad immune protection due to its genetic and antigenic diversity.To date,there are n...
关键词:Norovirus(NoV) Quadrivalent vaccine Adenovirus vector 
NoV GⅡ.2亚型RT-RPA-CRISPR/Cas12a检测方法的建立
《中国动物检疫》2024年第8期90-97,共8页樊成 曾昊 卢星月 康婕 雷兰兰 刘静 郑玉红 钱卫东 王婷 
国家市场监管总局科技计划项目(2021MKl07);西安市未央区科技计划项目(202208)。
近年来,一种新的诺如病毒GⅡ.2亚型(norovirus GⅡ.2,NoV GⅡ.2)通过牡蛎等生食海鲜感染人群,引发急性胃肠炎,并在全球广泛传播。为实现NoV感染的现场诊断和快速疫情响应,亟需建立快速便捷的NoV GⅡ.2亚型核酸检测方法。本研究通过设计...
关键词:NoV GⅡ.2亚型 反转录重组酶聚合酶扩增 CRISPR/Cas12a系统 快速检测 
A novel mouse model of calcific aortic valve stenosis
《Animal Models and Experimental Medicine》2024年第4期523-532,共10页Ningjing Qian Yaping Wang Wangxing Hu Naifang Cao Yi Qian Jinyong Chen Juan Fang Dilin Xu Haochang Hu Shuangshuang Yang Dao Zhou Hanyi Dai Dongdong Wei Jian'an Wang Xianbao Liu 
National Natural Science Foundation of China,Grant/Award Number:81770252,82030014,82271606 and U22A20267;Binjiang Institute of Zhejiang University,Grant/Award Number:ZY202205SMKY001;Key Program of Major Science and Technology Projects in Zhejiang Province,Grant/Award Number:2021C03097 and 2022C03063。
Background:Calcific aortic valve stenosis(CAVS)is one of the most challenging heart diseases in clinical with rapidly increasing prevalence.However,study of the mecha-nism and treatment of CAVS is hampered by the lack...
关键词:animal model calcific aortic valve stenosis valve calcification 
Intranasal adenovirus-vectored Omicron vaccine induced nasal immunoglobulin A has superior neutralizing potency than serum antibodies
《Signal Transduction and Targeted Therapy》2024年第8期3507-3518,共12页Si Chen Zhengyuan Zhang Qian Wang Qi Yang Li Yin Lishan Ning Zhilong Chen Jielin Tang Weiqi Deng Ping He Hengchun Li Linjing Shi yjun Deng Zijian Liu Hemeng Bu Yaohui Zhu Wenming Liu Linbing Qu Ligiang Feng Xiaoli Xiong Baoqing Sun Nanshan Zhong Feng Li ingchao Li Xinwen Chen Ling Chen 
The study was supported by the National Natural Science Foundation(92269201);Youth Innovation Promotion Association of CAS(2022361);Grants from Guangzhou National Laboratory(GZNL2024A01012,GZNL2023A01009);State Key Laboratory of Respiratory Disease(SKLRD-Z-202106,SKLRD-Z-202328);Science and Technology Projects in Guangzhou(SL2022A04J00604).
The upper respiratory tract is the initial site of SARS-CoV-2 infection.Nasal spike-specific secretory immunoglobulin A(slgA)correlates with protection against Omicron breakthrough infection.We report that intranasal ...
关键词:NASAL ANTIBODIES neutral 
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