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GENETHERAPY: 作品数：12被引量：33H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关机构：辽宁省血液中心青岛大学医学院附属医院更多>>; 相关期刊：《Genes & Diseases》《Zoological Research》《Acta Pharmacologica Sinica》《中国组织工程研究》更多>>; 相关基金：国家自然科学基金国家教育部博士点基金沈阳市科学技术计划项目上海市青年科技启明星计划更多>>

GAPDH suppresses adenovirus-induced oxidative stress and enables a superfast production of recombinant adenovirus: 《Genes & Diseases》2024年第6期367-380,共14页Guozhi Zhao Piao Zhao Yonghui Wang Hui Zhang Yi Zhu Jiamin Zhong Wulin You Guowei Shen Changi Luo Ou Mei Xingye Wu Jingjing Li Yi Shu Hongwei Wang Wiliam Wagstaff Hue HLuu Yang Bi Lewis LShi Russell RReid Tong-Chuan He Li Jiang Wei Tang Jiaming Fan Ziwei Tang; supported in part by research grants from the Natural Science Foundation of China (No.82000744 to ZT,and 82102696 to J.F.);the Chongqing Bayu Young Scholar Award (China) (to J.F.);the 2019 Funding for Postdoctoral Research (Chongqing Human Resources and Social Security Bureau of China) (No.298 to J.F.);the National Institutes of Health (No.CA226303 to T.C.H.,DE030480 to R.R.R.);supported by the Medical Scientist Training Program of the National Institutes of Health (USA) (No.T32 GM007281);supported in part by The University of Chicago Cancer Center Support Grant (No.P30CA014599);the National Center for Advancing Translational Sciences of the National Institutes of Health through grant number 2UL1TR002389-06 that funds the Institute for Translational Medicine (ITM);supported by the Mabel Green Myers Research Endowment Fund and The University of Chicago Orthopaedics Alumni Fund.; Recombinant adenovirus(rAdV)is a commonly used vector system for gene transfer.Efficient initial packaging and subsequent production of rAdV remains time-consuming and labor-intensive,possibly attributable to rAdv inf...; 关键词：GAPDH GENETHERAPY Oxidative stress Packaging cell line Reactive oxygen species Recombinant adenovirus

pIL-12 delivered by polymer based nanovector for anti-tumor genetherapy: 《Chinese Chemical Letters》2023年第11期209-213,共5页Lianbin Wen Xin Zan Qidi Pang Yuzhu Hu Songping Zheng Mengni Ran Xiang Gao Xiang Wang Bilan Wang; supported by the National Natural Science Foundation of China(No.81972347);the Key R&D Projects of the Science and Technology Department of Sichuan Province(No.2022YFS0324).; Finding more effective and safe non-viral vectors to transfer genes into cancer cells has become the key of immune gene therapy for cancer.Herein a triblock compound MPEG_(2000)-PDLLA_(4000)-MPEG_(2000) modified by ca...; 关键词：Non-viral vector Cancer gene therapy pIL-12 Immune response NANOCOMPOSITE

The big bang of genome editing technology: development and application of the CRISPR/Cas9 system in disease animal models被引量：4: 《Zoological Research》2016年第4期191-204,共14页Ming SHAO Tian-Rui XU Ce-Shi CHEN; partially supported by the National Natural Science Foundation of China(81202110,81120108019,U1132605 and 81325016); Targeted genome editing technology has been widely used in biomedical studies. The CRISPR- associated RNA-guided endonuclease Cas9 has become a versatile genome editing tool. The CRISPR/Cas9 system is useful for study...; 关键词：CRISPR/Cas9 Animal models GENETHERAPY

Targeting adeno-associated virus and adenoviral genetherapy for hepatocellular carcinoma被引量：2: 《World Journal of Gastroenterology》2016年第1期326-337,共12页Yi-Gang Wang Pan-Pan Huang Rong Zhang Bu-Yun Ma Xiu-Mei Zhou Yan-Fang Sun; Supported by National Natural Science Foundation of China.No.81272687;Zhejiang Provincial Public Welfare Technology Application Research Projects,No.2014C33275;Zhejiang Provincial Natural Science Foundation of China,No.LZ13H160004;the Grant for 521 Talent Project of Zhejiang Sci-Tech University,Hangzhou,China; Human hepatocellular carcinoma(HCC)heavily endangers human heath worldwide.HCC is one of most frequent cancers in China because patients with liver disease,such as chronic hepatitis,have the highest cancer susceptibil...; 关键词：Hepatocellular carcinoma Adeno-associatedvirus ADENOVIRUS VIRUS VECTORS

基因转染间充质干细胞的临床治疗:特点与问题被引量：3: 《中国组织工程研究》2014年第14期2257-2262,共6页李丽春李剑平; 沈阳市科学技术计划项目(F10-206-1-00)~~; 背景:骨髓间充质干细胞因制备较易、具备有较强的自我增殖能力、稳定的生物学性状、低免疫原性、能在宿主脑中生存较长时间、易于转染外源性基因且有较高的转染率、对肿瘤细胞具有趋向性而成为一种较有希望的基因治疗的靶细胞。目的:利...; 关键词：骨髓间充质干细胞临床治疗基因转染中国期刊全文数据库体细胞基因治疗移植物抗宿主病 GENETHERAPY 外源性基因

Prospect of Functional Salivary Gland Enhancement with Biomedical Strategies for Head and Neck Cancers被引量：2: 《Chinese Journal of Clinical Oncology》2008年第5期313-319,共7页Suyu Zhu Bingqiang Hu Xiao Zhou; Xerostomia is the main complication inflicting head and neck cancer patients treated with radiotherapy.Conventional treatment is not very effective in alleviating this morbidity.Biomedical strategies such as gene tran...; 关键词：XEROSTOMIA salivary gland radiation injury GENETHERAPY tissue engineering.

Gaucher disease:New developments in treatment and etiology被引量：2: 《World Journal of Gastroenterology》2008年第25期3968-3973,共6页Ozgur Harmanci Yusuf Bayraktar; Hacettepe University Faculty of Medicine; Gaucher disease (GD) is an autosomal recessive disease which if undiagnosed or diagnosed late results in devastating complications. Because of the heterozygous nature of GD, there is a wide spectrum of clinical presen...; 关键词：Gaucher disease Enzyme replacementtreatment Substrate reduction treatment GENETHERAPY Liver fibrosis

Genetically engineered K cells provide sufficient insulin to correct hyperglycemia in a nude murine model被引量：4: 《Acta Biochimica et Biophysica Sinica》2008年第2期149-157,共9页Yiqun Zhang Liqing Yao Kuntang Shen Meidong Xu Pinghong Zhou Weige Yang Xinyuan Liu Xinyu Qin; A gene therapy-based treatment of type 1 diabetes mellitus requires the development of a surrogate β cell that can synthesize and secrete functionally active insulin in response to physiologically relevant changes in...; 关键词：type 1 diabetes mellitus INSULIN GENETHERAPY glucose-dependent insulinotropic polypeptide STC-1 cell glucose

Rat adipose-derived stromal cells expressing BMP4 induce ectopic bone formation in vitro and in vivo被引量：16: 《Acta Pharmacologica Sinica》2006年第12期1608-1615,共8页Lin LIN Xin FU Xin ZHANG Lian-xu CHEN Ji-ying ZHANG Chang-long YU Kang-tao MA Chun-yan ZHOU; Project supported by the program of gene therapy on sports injury sponsored by the State Sports General Administration of China.; Aim： Bone morphogenetic protein 4 （BMP4） is one of the main local contributing factors in callus formation in the early phase of fracture healing. Adipose-derived stromai cells （ADSC） are multipotent cells. The p...; 关键词：adipose-derived stromal cells BMP4 GENETHERAPY bone formation

GENETICALLY MODIFIED DENDRITIC CELLS INDUCED SPECIFIC CYTOTOXITY AGAINST HUMAN HCC CELLS IN VITRO: 《Chinese Journal of Cancer Research》2004年第4期246-250,共5页刘彬彬叶胜龙贺平郑宁赵燕孙瑞霞刘银坤汤钊猷; This work was supported by NationalNatural Science Foundation of China (No. 39770826) andpartly by CMB (No. 93583).; Objective: to transduce the tumor associated antigen gene MAGE-1 and/or IL-12 gene into dendritic cells (DC) and to observe the in vitro cytotoxic effect induced by the genetically modified DC against the human hepato...; 关键词：MAGE-1 IL-12 Dendritic cells Tumor vaccine GENETHERAPY Hepatocellular carcinoma

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