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BIVALENT: 作品数：41被引量：34H指数：4; 导出分析报告; 相关领域：医药卫生农业科学更多>>; 相关作者：周炼王飞俊邵自强更多>>; 相关机构：华南农业大学北京理工大学更多>>; 相关期刊：《Science Bulletin》《Journal of Microbiology and Immunology》《Current Medical Science》《Chinese Medical Sciences Journal》更多>>; 相关基金：国家自然科学基金中国博士后科学基金广东省自然科学基金上海市青年科技启明星计划更多>>

Utilizing bivalent aptamers as first DNA agonist to activate RTKs heterodimer of different families: 《Chinese Chemical Letters》2025年第1期474-477,共4页Kun Liu Yulin Cong Xiongfeng Luo Meicun Yao Zhiyong Xie Hao Li; the National Natural Science Foundation of China(Nos.22104158,82174104,U1903211);the Natural Science Foundation of Hunan Province(No.2021JJ40041);Guangdong Basic and Applied Basic Research Foundation(No.2023A1515011346);Shenzhen Science and Technology Program(No.SZBH202130)。; Heterodimerization in RTKs is of vital importance in the RTK signaling and cell functions.Heterodimerization between RTKs can result in diversity of downstream signals,increasing the ability of cells to respond to ext...; 关键词：DNA Agonist Bivalent aptamers RTKs heterodimer

A bivalent Delta/BA.5 mRNA vaccine elicits broad immune responses against various lineages of SARS-CoV-2 including JN.1: 《Virologica Sinica》2024年第5期833-835,共3页Kangyin Li Qi Liu Yan Wu Bihao Wu Shaohong Chen Xinghai Zhang Xiaoying Jia Rui Gong Yucai Peng Huajun Zhang Sandra Chiu; Dear Editor,The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has posed a continuous threat to global public health.A number of vaccines,such as inactivated vaccines,mRNA vaccines,recombinant ade...; 关键词：acute RESPIRATORY

PRC2 primes bivalent genes for transcription induction independent of histone methyltransferase activity: 《Science China(Life Sciences)》2024年第9期2033-2035,共3页Meihan Gong Ye Yuan Zhongye Dai Xuejiao Lv Jiacheng Su Dawei Huo Lin Niu Xu Chen Xudong Wu; supported by the National Natural Science Foundation of China(32320103009,31970579);the National Youth Talent Support Program。; Dear Editor,Polycomb group proteins,conserved epigenetic transcriptional repressors,are crucial for orchestrating diverse developmental gene expression programs(Schuettengruber et al.,2017).The polycomb repressive com...; 关键词：valent thereby subsequent

Construction of a bivalent vaccine candidate against HAdV4/HAdV7 based on capsid-display strategy via Red-homologous recombination and counter-selection methodology: 《Biosafety and Health》2024年第2期70-79,共10页Peng Wang Yunting Shao Xichun Yang Wenning Zhang Jianguang Zhou Fang Huang Shuang Liu Jiping Zheng Chengjun Wu Shanhu Li; supported by grants from the National Key Research and Development Program of China(Grant No.2018YFA0900800).; Human adenoviruses(HAdvs)are major respiratory pathogens.Specifically,human adenovirus type 4(HAdV4)and human adenovirus type 7(HAdV7)are known for causing fever and pneumonia,with docu-mented cases of fatalities amon...; 关键词：Bivalent adenovirus vaccine Capsid-display strategy ITRs modification Hexon epitope replacement

Safety,immunogenicity,and preliminary efficacy of a randomized clinical trial ofomicron XBB.1.5-containing bivalent mRNA vaccine: 《hLife》2024年第3期113-125,共13页Xuanjing Yu Wei Yang Wei Li Na Wan Guanghong Yan Zumi Zhou Xiao Zhu Wei Su Yani Li Chenyu Xing Sifan Duan Houze Yu Xinshuai Zhao Chunmei Li Taicheng Zhou Dingyun You Jia Wei Zijie Zhang; supported by a grant(2023YFC2307600,to Z.J.Z.)from the Na-tional Key Research and Development Program of China;a grant(202102AA100051,to Z.J.Z.)from the Yunnan Provincial Sci-ence and Technology Department,China;a grant(H-2018102,to J.W.)from the High-level Health Technical Personnel Project of Yunnan Province,China;a grant(2022SCP001,to Z.J.Z.)from the Spring City Plan:The High-level Talent Promotion and Training Project of Kunming;and a grant(32371000,to C.M.L.)from the National Natural Science Foundation of China.; Periodically updating coronavirus disease 19(COVID-19)vaccines that offer broad-spectrum protection is needed giventhe strong immune evasion by the circulating omicron sublineages.The effectiveness of prototype and BA...; 关键词：severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) JN.1 XBB lineages coronavirus disease19(COVID-19)vaccine mRNA bivalent vaccine randomized clinical trial

Equitable bivalent booster allocation strategies against emerging SARS-CoV-2 variants in US cities with large Hispanic communities:The case of El Paso County,Texas被引量：1: 《Infectious Disease Modelling》2023年第3期912-919,共8页Francis Owusu-Dampare Anass Bouchnita; supported by the Counsil of State and Territorial Epidemiologists(grant no.NU38OT000297).; COVID-19 is a disease that disproportionately impacts the Hispanic population,due to the prevalence of certain risk factors and the high number of essential workers in this com-munity.In this work,we analyze the vacci...; 关键词：Mathematical modeling COVID-19 Hispanic health disparities Bivalent boosters

Optimization of the Process for Preparing Bivalent Polysaccharide Conjugates to Develop Multivalent Conjugate Vaccines against Streptococcus pneumoniae or Neisseria meningitidis and Comparison with the Corresponding Licensed Vaccines in Animal Models被引量：1: 《Current Medical Science》2023年第1期22-34,共13页Fang HUANG Xiao-bing JING Yin-bo LI Qian WANG Si-li LIU Zhi-rong YANG Su FENG; Objective:This study aimed to describe,optimize and evaluate a method for preparing multivalent conjugate vaccines by simultaneous conjugation of two different bacterial capsular polysaccharides(CPs)with tetanus toxoi...; 关键词：multivalent conjugate vaccine pneumococcal conjugate vaccine meningococcal conjugate vaccine BIOCONJUGATION IMMUNOGENICITY

A versatile strategy for convenient circular bivalent functional nucleic acids construction: 《National Science Review》2023年第2期141-151,共11页Xiao-Jing Zhang Zhuo Zhao Xia Wang Min-Hui Su Lili Ai Yingying Li Quan Yuan Xue-Qiang Wang Weihong Tan; supported by the National Key R&D Program of China(2018YFA0902300);the Huxiang Young Talent Program from Hunan Province(2019RS2022);the Science and Technology Project of Hunan Province(2019sk2201)。; Functional nucleic acids(FNAs),such as aptamers,nucleic acid enzymes and riboswitches play essential roles in various fields of life sciences.Tailoring of ingenious chemical moieties toward FNAs can enhance their biom...; 关键词：circular bivalent aptamers click chemistry chemical ligation

Mucosal immune responses and protective efficacy in yellow catfish after immersion vaccination with bivalent inactivated Aeromonas veronii and Edwardsiella ictaluri vaccine: 《Water Biology and Security》2022年第2期38-48,共11页Wei Guang Kong Da Cheng Qin Qing Jiang Mu Zhao Ran Dong Yang Zhi Luo Tao Shan Ai Zhen Xu; Mucosal vaccination,which has the potential to induce both mucosal and systemic immune responses,is considered the most suitable method of preventing infectious diseases in farmed fish.Aeromonas veronii and Edwardsiel...; 关键词：Mucosal immune response Bivalent inactivated vaccine Immersion vaccination Aeromonas veronii Edwardsiella ictaluri Yellow catfish

Molecular dynamics simulations of A-DNA in bivalent metal ions salt solution: 《Chinese Physics B》2022年第4期733-741,共9页Jingjing Xue Xinpeng Li Rongri Tan Wenjun Zong; supported by the National Natural Science Foundation of China(Grant No.11564015);the Foundation of Educational Committee of Jiangxi Province,China(Grant No.GJJ211112);the Fund for Distinguished Young Scholars of Jiangxi Science&Technology Normal University(Grant No.2015QN-BJRC002)。; A-form DNA is one of the biologically active double helical structure.The study of A-DNA structure has an extensive application for developing the field of DNA packaging in biotechnology.In aqueous solution,the A-DNA ...; 关键词：transition of DNA structure bivalent metal ions molecular dynamics simulations effect of concentration

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