STRUCTURE-BASED

作品数：108被引量：289H指数：8
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相关作者：杨庆王恩利窦喜英韩立国鄢高韩更多>>
相关机构：中国石油天然气集团公司吉林大学北京中医药大学同济大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金中国博士后科学基金更多>>
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Microstructure-based Investigation of the Mechanical and Gas Permeability Properties of Stone Powder-doped Mortar
《Journal of Wuhan University of Technology(Materials Science)》2025年第2期519-532,共14页MIAO Gaixia XUE Cuizhen ZHOU Aoxiang ZHANG Yunsheng HAN Yixuan QIAO Hongxia 
Funded by the National Natural Science Foundation of China project(Nos.52108219 and U21A20150);the Lanzhou University of Technology Hongliu Outstanding Young Talent Program,China(No.04-062407);the Research on Quality Control Technology of High-performance Concrete Prepared by Manufactured Sand(No.2020Y21)。
In view of the increased focus on“green”and sustainable development and compliance with the national strategy for“carbon peak and carbon neutrality,”this study investigated the effect of replacing cement(0-20%)wit...
关键词：limestone powder APPLICABILITY micro-meso scale mechanical property gas permeability gray-correlation analysis 
A novel loop-structure-based bispecific CAR that targets CD19 and CD22 with enhanced therapeutic efficacy against B-cell malignancies
《Protein & Cell》2025年第3期227-232,共6页Lijun Zhao Shuhong Li Xiaoyi Wei Xuexiu Qi Qiaoru Guo Licai Shi Ji-Shuai Zhang Jun Li Ze-Lin Liu Zhi Guo Hongyu Zhang Jia Feng Yuanyuan Shi Suping Zhang Yu J.Cao 
supported by the National Key R&D Program of China(2019YFA0906100 and 2019YFA0904200 to Y.J.C.);the Shenzhen Science and Technology Innovation Program(JCYJ20180504165501371 to Y.J.C.);the National Natural Science Foundation of China(32171464 and 81872783 to Y.J.C.),the Prevention and Control of COVID-2019 Research Program in University of Guangdong Province(2020KZDZX1176 to S.Z.);the Shenzhen Basic Research Program(JCYJ20180507182203049 to S.Z.);the Shenzhen Key Laboratory Foundation(ZDSYS20200811143757022 to S.Z.).
Dear Editor,Chimeric antigen receptor T(CAR-T)cells have achieved substantial advances in the treatment of B-cell malignancies.Despite high initial response rates,some patients relapse,characterized by targeted antige...
关键词：B cell malignancies therapeutic efficacy targeted antigen loss shalabi bispecific CAR T cells CD 
A structure-based virtual screening identifies a novel MDM2 antagonist in the activation of the p53 signaling and inhibition of tumor growth
《Acta Pharmacologica Sinica》2025年第3期740-750,共11页Qing-yong Hu Lei Li Yu-huang Li Hai-bo Zhang Tao Deng Yang Liu Feng-tian Li Zhi-xiong Xiao Yang Cao 
supported by the National Natural Science Foundation of China(Grant numbers 81973243,81861148031,81520108020 and 31401130).
p53,a tumor suppressor protein,has a vital role in the regulation of the cell cycle,apoptosis,and DNA damage repair.The degradation of p53 is predominantly controlled by the murine double minute 2(MDM2)protein,a ubiqu...
关键词：MDM2 P53 virtual screening inhibitor 
Structure-based insights into fluorogenic RNA aptamers被引量：1
《Acta Biochimica et Biophysica Sinica》2025年第1期108-118,共11页Qianqian Song Xiaoqing Tai Qianyu Ren Aiming Ren 
supported by the grants from the Natural Science Foundation of China(Nos.32325029,32022039,91940302,and 91640104);the National Key Research and Development Project of China(Nos.2023YFC2604300 and 2021YFC2300300).
Fluorogenic RNA aptamers are in vitro-selected RNA molecules capable of binding to specific fluorophores,significantly increasing their intrinsic fluorescence.Over the past decade,the color palette of fluorescent RNA ...
关键词：fluorogenic RNA aptamers tertiary structures base quadruples base triples fluorescence activation mechanisms G-QUADRUPLEX 
Association between Per and Polyfluoroalkyl Substance and Abdominal Fat Distribution:A Trait Spectrum Exposure Pattern and Structure-Based Investigation
《Biomedical and Environmental Sciences》2025年第1期3-14,共12页Zhi Li Shilin Shan Chenyang Song Chengzhe Tao Hong Qian Qin Yuan Yan Zhang Qiaoqiao Xu Yufeng Qin Yun Fan Chuncheng Lu 
supported by the National Key R&D Program of China(No.2021YFC2700605);the National Natural Science Foundation of China(82071700 and 82101679);333 High-level Talent Training Project of the Jiangsu Province((2022)3-16-425);the Natural Science Foundation of Jiangsu Province(BK20220317);Jiangsu Funding Program for Excellent Postdoctoral Talent(2022ZB414);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB330001);China Postdoctoral Science Foundation(2022M711673).
Objective To investigate the associations between eight serum per-and polyfluoroalkyl substances(PFASs)and regional fat depots,we analyzed the data from the National Health and Nutrition Examination Survey(NHANES)2011...
关键词：Per-and polyfluoroalkyl substances Regional fat depots OBESITY STRUCTURE-BASED NHANES 
Ground-to-air wireless coverage extension for 6G: a triangular prism structure-based approach被引量：1
《Science China(Information Sciences)》2024年第12期314-316,共3页Junyu LIU Min SHENG Jiandong LI Xuhui CHEN Chenxi ZHAO 
supported in part by National Key Research and Development Program of China (Grant No.2020YFB1807000);National Natural Science Foundation of China (Grant Nos.62121001,62171344,62341111)。
Stimulated by the requirements of passenger transport,cargo delivery, security monitoring, etc., the development of a low-altitude economy has been entering a new stage [1].Relying on the low-altitude airspace below 1...
关键词：ALTITUDE TRIANGULAR structure 
Hybrid machine learning and microstructure-based approach for modeling relationship between microstructure and hardness of AA2099 Al−Li alloy
《Transactions of Nonferrous Metals Society of China》2024年第11期3504-3520,共17页Xiang-hui ZHU Xu-sheng YANG Wei-jiu HUANG Miao GONG Xin WANG Meng-di LI 
financially supported by the National Natural Science Foundation of China (No.51871038);the Natural Science Foundation of Chongqing,China (Nos.CSTB2022NSCQ-LZX0002,cstc2021jcyjmsxm X0960)。
A hybrid approach combining machine learning and microstructure analysis was proposed to investigate the relationship between microstructure and hardness of AA2099 Al−Li alloy through nano-indentation,X-ray diffractio...
关键词：machine learning T_(1)phase HARDNESS Al−Li alloy 
Structure-based discovery of F.religiosa phytochemicals as potential inhibitors against Monkeypox(mpox)viral protein
《Journal of Biosafety and Biosecurity》2024年第3期157-169,共13页Ranjan K.Mohapatra Ahmed Mahal Pranab K.Mohapatra Ashish K.Sarangi Snehasish Mishra Meshari A.Alsuwat Nada N.Alshehri Sozan M.Abdelkhalig Mohammed Garout Mohammed Aljeldah Ahmad A.Alshehri Ahmed Saif Mohammed Abdulrahman Alshahrani Ali S.Alqahtani Yahya A.Almutawif Hamza M.A.Eid Faisal M Albaqami Mohnad Abdalla Ali A.Rabaan 
Outbreaks of Monkeypox(mpox)in over 100 non-endemic countries in 2022 represented a serious global health concern.Once a neglected disease,mpox has become a global public health issue.A42R profilinlike protein from mp...
关键词：MONKEYPOX Mpox PHYTOCHEMICAL Molecular docking MD simulation ADMET QSAR 
Solid-state non-volatile memories based on vdW heterostructure-based vertical-transport ferroelectric field-effect transistors
《Science China(Information Sciences)》2024年第6期194-202,共9页Qiyu YANG Zheng-Dong LUO Fei XIAO Junpeng ZHANG Dawei ZHANG Dongxin TAN Xuetao GAN Yan LIU Zhufei CHU Yinshui XIA Genquan HAN 
supported by National Key R&D Program of China(Grant No.2023YFB4402303);National Natural Science Foundation of China(Grant Nos.62090033,62025402,62274128,92264202,62293522,92364204);Zhejiang Provincial Natural Science Foundation of China(Grant Nos.LDT23F04023F04,LDT23F04024F04,LR21F010003);Fundamental Research Funds for the Central Universities(Grant No.QTZX23079);Key Research and Development Program of Ningbo City(Grant No.2023Z071)。
Driven by the explosive development of data-centric computation applications,it is becoming urgent to develop in-memory computing devices that are beyond the von Neumann architecture with an arrangement of separated l...
关键词：vdW heterostructure non-volatile memory vertical-transport transistor ferroelectric field-effect transistor memristive devices 
Exploring structure-based drug discovery of GPCRs beyond the orthosteric binding site
《hLife》2024年第5期211-226,共16页Zhao Chen Xintong Ren Yu Zhou Niu Huang 
This work is supported by Beijing Municipal Science&Technology Commission(Z201100005320012 to N.H.)and Tsinghua University.
G-protein coupled receptors(GPCRs)are the largest family of druggable targets.In recent years,GPCR structural biology has made great advances,revealing the three-dimensional structures of many GPCRs and their interact...
关键词：G-protein coupled receptor(GPCR) allosteric pocket structure-based virtual screening(SBVS) negative allosteric modulator(NAM) positive allosteric modulator(PAM) artificial intelligence(AI) 
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