云南高校图书馆联盟文献共享服务平台- STRUCTURE-BASED

STRUCTURE-BASED: 作品数：105被引量：287H指数：8; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：杨庆王恩利窦喜英韩立国鄢高韩更多>>; 相关机构：中国石油天然气集团公司吉林大学北京中医药大学同济大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划北京市自然科学基金中国博士后科学基金更多>>

Microstructure-based Investigation of the Mechanical and Gas Permeability Properties of Stone Powder-doped Mortar: 《Journal of Wuhan University of Technology(Materials Science)》2025年第2期519-532,共14页MIAO Gaixia XUE Cuizhen ZHOU Aoxiang ZHANG Yunsheng HAN Yixuan QIAO Hongxia; Funded by the National Natural Science Foundation of China project(Nos.52108219 and U21A20150);the Lanzhou University of Technology Hongliu Outstanding Young Talent Program,China(No.04-062407);the Research on Quality Control Technology of High-performance Concrete Prepared by Manufactured Sand(No.2020Y21)。; In view of the increased focus on“green”and sustainable development and compliance with the national strategy for“carbon peak and carbon neutrality,”this study investigated the effect of replacing cement(0-20%)wit...; 关键词：limestone powder APPLICABILITY micro-meso scale mechanical property gas permeability gray-correlation analysis

Association between Per and Polyfluoroalkyl Substance and Abdominal Fat Distribution:A Trait Spectrum Exposure Pattern and Structure-Based Investigation: 《Biomedical and Environmental Sciences》2025年第1期3-14,共12页Zhi Li Shilin Shan Chenyang Song Chengzhe Tao Hong Qian Qin Yuan Yan Zhang Qiaoqiao Xu Yufeng Qin Yun Fan Chuncheng Lu; supported by the National Key R&D Program of China(No.2021YFC2700605);the National Natural Science Foundation of China(82071700 and 82101679);333 High-level Talent Training Project of the Jiangsu Province((2022)3-16-425);the Natural Science Foundation of Jiangsu Province(BK20220317);Jiangsu Funding Program for Excellent Postdoctoral Talent(2022ZB414);the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(22KJB330001);China Postdoctoral Science Foundation(2022M711673).; Objective To investigate the associations between eight serum per-and polyfluoroalkyl substances(PFASs)and regional fat depots,we analyzed the data from the National Health and Nutrition Examination Survey(NHANES)2011...; 关键词：Per-and polyfluoroalkyl substances Regional fat depots OBESITY STRUCTURE-BASED NHANES

Ground-to-air wireless coverage extension for 6G: a triangular prism structure-based approach被引量：1: 《Science China(Information Sciences)》2024年第12期314-316,共3页Junyu LIU Min SHENG Jiandong LI Xuhui CHEN Chenxi ZHAO; supported in part by National Key Research and Development Program of China (Grant No.2020YFB1807000);National Natural Science Foundation of China (Grant Nos.62121001,62171344,62341111)。; Stimulated by the requirements of passenger transport,cargo delivery, security monitoring, etc., the development of a low-altitude economy has been entering a new stage [1].Relying on the low-altitude airspace below 1...; 关键词：ALTITUDE TRIANGULAR structure

Hybrid machine learning and microstructure-based approach for modeling relationship between microstructure and hardness of AA2099 Al−Li alloy: 《Transactions of Nonferrous Metals Society of China》2024年第11期3504-3520,共17页Xiang-hui ZHU Xu-sheng YANG Wei-jiu HUANG Miao GONG Xin WANG Meng-di LI; financially supported by the National Natural Science Foundation of China (No.51871038);the Natural Science Foundation of Chongqing,China (Nos.CSTB2022NSCQ-LZX0002,cstc2021jcyjmsxm X0960)。; A hybrid approach combining machine learning and microstructure analysis was proposed to investigate the relationship between microstructure and hardness of AA2099 Al−Li alloy through nano-indentation,X-ray diffractio...; 关键词：machine learning T_(1)phase HARDNESS Al−Li alloy

Structure-based discovery of F.religiosa phytochemicals as potential inhibitors against Monkeypox(mpox)viral protein: 《Journal of Biosafety and Biosecurity》2024年第3期157-169,共13页Ranjan K.Mohapatra Ahmed Mahal Pranab K.Mohapatra Ashish K.Sarangi Snehasish Mishra Meshari A.Alsuwat Nada N.Alshehri Sozan M.Abdelkhalig Mohammed Garout Mohammed Aljeldah Ahmad A.Alshehri Ahmed Saif Mohammed Abdulrahman Alshahrani Ali S.Alqahtani Yahya A.Almutawif Hamza M.A.Eid Faisal M Albaqami Mohnad Abdalla Ali A.Rabaan; Outbreaks of Monkeypox(mpox)in over 100 non-endemic countries in 2022 represented a serious global health concern.Once a neglected disease,mpox has become a global public health issue.A42R profilinlike protein from mp...; 关键词：MONKEYPOX Mpox PHYTOCHEMICAL Molecular docking MD simulation ADMET QSAR

Solid-state non-volatile memories based on vdW heterostructure-based vertical-transport ferroelectric field-effect transistors: 《Science China(Information Sciences)》2024年第6期194-202,共9页Qiyu YANG Zheng-Dong LUO Fei XIAO Junpeng ZHANG Dawei ZHANG Dongxin TAN Xuetao GAN Yan LIU Zhufei CHU Yinshui XIA Genquan HAN; supported by National Key R&D Program of China(Grant No.2023YFB4402303);National Natural Science Foundation of China(Grant Nos.62090033,62025402,62274128,92264202,62293522,92364204);Zhejiang Provincial Natural Science Foundation of China(Grant Nos.LDT23F04023F04,LDT23F04024F04,LR21F010003);Fundamental Research Funds for the Central Universities(Grant No.QTZX23079);Key Research and Development Program of Ningbo City(Grant No.2023Z071)。; Driven by the explosive development of data-centric computation applications,it is becoming urgent to develop in-memory computing devices that are beyond the von Neumann architecture with an arrangement of separated l...; 关键词：vdW heterostructure non-volatile memory vertical-transport transistor ferroelectric field-effect transistor memristive devices

Exploring structure-based drug discovery of GPCRs beyond the orthosteric binding site: 《hLife》2024年第5期211-226,共16页Zhao Chen Xintong Ren Yu Zhou Niu Huang; This work is supported by Beijing Municipal Science&Technology Commission(Z201100005320012 to N.H.)and Tsinghua University.; G-protein coupled receptors(GPCRs)are the largest family of druggable targets.In recent years,GPCR structural biology has made great advances,revealing the three-dimensional structures of many GPCRs and their interact...; 关键词：G-protein coupled receptor(GPCR) allosteric pocket structure-based virtual screening(SBVS) negative allosteric modulator(NAM) positive allosteric modulator(PAM) artificial intelligence(AI)

Process synthesis for the separation of coal-to-ethanol products: 《Chinese Journal of Chemical Engineering》2024年第5期263-278,共16页Qingping Qu Daoyan Liu Hao Lyu Jinsheng Sun; The coal-to-ethanol process,as the clean coal utilization,faces challenges from the energy-intensive distillation that separates multi-component effluents for pure ethanol.Referring to at least eight columns,the synth...; 关键词：Coal-to-ethanol Process synthesis Superstructure-based optimization Differential evolution algorithm DISTILLATION

Structure-based out-of-distribution(OOD)materials property prediction:a benchmark study: 《npj Computational Materials》2024年第1期1753-1766,共14页Sadman Sadeed Omee Nihang Fu Rongzhi Dong Ming Hu Jianjun Hu; supported in part by National Science Foundation under the grants 2110033,OAC-2311203,and 2320292.; In real-world materials research,machine learning(ML)models are usually expected to predict and discover novel exceptional materials that deviate from the known materials.It is thus a pressing question to provide an o...; 关键词：PROPERTY PREDICTION DISTRIBUTION

Structure-based development of potent and selective type-II kinase inhibitors of RIPK1: 《Acta Pharmaceutica Sinica B》2024年第1期319-334,共16页Ying Qin Dekang Li Chunting Qi Huaijiang Xiang Huyan Meng Jingli Liu Shaoqing Zhou Xinyu Gong Ying Li Guifang Xu Rui Zu Hang Xie Yechun Xu Gang Xu Zheng Zhang Shi Chen Lifeng Pan Ying Li Li Tan; We thank Prof.Junying Yuan(IRCBC of CAS,Shanghai,China)and Dr.Jidong Zhu(Etern Therapeutics,Shanghai,China)for their generous help on this work,Dr.Sudan He(ISM of CAMS,Suzhou,China)for providing RIPK3-FKBP NIH/3T3 cells,and National Facility for Protein Science in Shanghai(China)for the help in animal studies.This work was supported by grants from the National Natural Science Foundation of China(Grants Nos.21837004,82151212,and 32170755);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39050500,China);Shanghai Municipal Science and Technology Major Project(Grant No.2019SHZDZX02,China).; Receptor-interacting serine/threonine-protein kinase 1(RIPK1)functions as a key regulator in inflammation and cell death and is involved in mediating a variety of inflammatory or degenerative diseases.A number of allo...; 关键词：RIPK1 NECROPTOSIS Type-II kinase inhibitors Rational design Lead optimization Structure‒activity relationship ANTI-INFLAMMATION Preclinical drug discovery

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