LANOSTEROL

作品数：9被引量：16H指数：2
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相关领域：医药卫生理学更多>>
相关作者：巫瑞波郑学忠杨敏赖茂祥黄平更多>>
相关机构：中山大学广西中医药研究所重庆医科大学更多>>
相关期刊：《Precision Clinical Medicine》《菌物学报》《Journal of Chinese Pharmaceutical Sciences》《Chinese Chemical Letters》更多>>
相关基金：国家自然科学基金上海市教育委员会重点学科基金更多>>
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Inhibitory effect of lanosterol on cataractous lens of cynomolgus monkeys using a subconjunctival drug release system Keke被引量：2
《Precision Clinical Medicine》2022年第3期166-175,共10页Zhang Wenwen He Yu Du Yugui Zhou Xiaokang Wu Jie Zhu Xiangjia Zhu Kang Zhang Yi Lu 
funded by research grants from the National Natural Science Foundation of China(Grants No.82122017,81870642,81970780,81670835,and 81700819);Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission(Grants No.19441900700 and 21S31904900);Clinical Science and Technology Innovation Project of Shanghai Shenkang Hospital Development Center(Grants No.SHDC12019X08 and SHDC2020CR4078)。
Background:To evaluate the effect of lanosterol on cataractous lens of cynomolgus monkeys using a subconjunctival drug release system.Methods:Nine elder cynomolgus monkeys were used,consisting of three monkeys without...
关键词：LANOSTEROL drug release CATARACT LENS MONKEYS 
Cataract: Advances in surgery and whether surgery remains the only treatment in future被引量：2
《Advances in Ophthalmology Practice and Research》2021年第1期49-54,共6页Xinyi Chen Jingjie Xu Xiangjun Chen Ke Yao 
supported by Program of National Natural Science Foundation of China(No.81870641)(No.82070939);Key Research and Development Project of Zhejiang Province,China(2020C03035).
Background:Cataract is the world's leading eye disease that causes blindness.The prevalence of cataract aged 40 years and older is approximately 11.8%–18.8%.Currently,surgery is the only way to treat cataracts.Main T...
关键词：CATARACT SURGERY FLACS FEMTOSECOND LANOSTEROL 
Design and synthesis of novel triazole antifungal derivatives based on the active site of fungal lanosterol 14a-demethylase(CYP51)被引量：5
《Chinese Chemical Letters》2009年第8期935-938,共4页Zhi Gang Dan Jun Zhang Shi Chong Yu Hong Gang Hu Xiao Yun Chai Qing Yan Sun Qiu Ye Wu 
supported by the National Natural Science Foundation of China(No.20772153);by Shanghai Leading Academic Discipline Project(No.B906).
A series of 1-（1H-1,2,4-triazole-1-yl）-2-（2,4-difluoropheny1）-3-（N-isoproy1-N-substituted-amino）-2-propanols have been designed and synthesized on the basis of the active site of lanosterol 14a-demethylase （CY...
关键词：TRIAZOLE SYNTHESIS Antifungal activity 
Design,synthesis and antifungal activities in vitro of novel tetralin compounds被引量：2
《Chinese Chemical Letters》2008年第3期264-268,共5页Hui Tang You Jun Zhou Yao Wu Li Jia Guo Lv Can Hui Zheng Jun Chen Ju Zhu 
Novel chiral tetralin compounds were designed and synthesized, and their antifungal activities in vitro were tested. The results showed that all of target compounds had potent antifungal activities, and were stronger ...
关键词：ANTIFUNGAL Chiral tetralins Lanosterol 14α-demethylase DESIGN SYNTHESIS 
Effects of culture media and three metal ions on the accumulation of lanosterol and ergosterol in cultured mycelia of Inonotus obliquus被引量：3
《菌物学报》2008年第1期126-139,共14页ZHENG Wei-Fa XIANG Xiao-Yan CHEN Cai-Fa WANG Yao ZHAO Yan-Xia JIANG Ji-Hong CHU Cheng-Cai 
Supported by Natural Science Foundation of the Education Department of Jiangsu Province （No. 05KJA36012）, and Natural Science Foundation of Jiangsu Province （BK2006034）
Lanosterol and ergosterol are the active principles with potential pharmacological activities in Inonotus obliquus. However, the two sterols are less accumulated in cultured mycelia of the fungus. In this study, diffe...
关键词：培养基 金属离子 桦褐孔菌 菌丝体 羊毛甾醇 麦角甾醇 积累 
Design, synthesis and molecular docking studies of novel triazole antifungal compounds被引量：1
《Chinese Chemical Letters》2007年第6期663-666,共4页Qiu Qin He Ke Li Yong Bing Cao Huan Wen Dong Li Hua Zhao Chao Mei Liu Chun Quan Sheng 
Based on the active site of Candida albicans lanosterol 14α-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized. In vitro antifungal ac...
关键词：Lanosterol 14α-demethylase TRIAZOLE TERT-BUTYL Antifungal activity Fluconazole-resistant 
Design, Synthesis and Biological Evaluation of Non-azole Inhibitors of Lanosterol 14α-Demethylase of Fungi被引量：1
《Chinese Chemical Letters》2006年第9期1189-1192,共4页Bin YAO You Jun ZHOU Jü ZHU Jia Guo Lü Yao Wu LI Jun CHENG Qing Feng JIANG Can Hui ZHENG 
supported by the National Natural Science Foundation of China(No.30572257)
Novel tetralin compounds were designed and synthesized on the three-dimensional model of lanosterol 14α-demethylase of Candida albicans. All of the lead compounds exhibited potent antifungal activities, especially co...
关键词：ANTIFUNGAL 2-aminotetralins lanosterol 14α-demethylase inhibitor. 
Homology modeling of lanosterol 14alpha-demethylase of Candida albicans and Aspergillus fumigatus and insights into the enzyme-substrate interactions
《第二军医大学学报》2005年第2期173-173,共1页
The crystal structure of 14alpha-sterol demethylase from Mycobacterium tuberculosis (MT_14DM) provides a good template for modeling the three dimensional structure of lanosterol 14alpha-demethylase, which is the targe...
Synthesis of 3 Nitrogen containing Function Substituted Lanosterol Derivatives Inhibitors of (S) Adenosyl L Me thionine:Δ 24(25) Sterol Methyltransferase
《Journal of Chinese Pharmaceutical Sciences》1997年第3期17-20,共4页黄平 杨敏 赖茂祥 郑学忠 西正敏 中西勤 
Syntheses of 3 ketolanosterol, 3 acetolanosterol, 3 oximolanosterol, 3α and 3β aminolanosterol were described The products have been fully characterized on the basis of their chromatographic (TLC R f, GLC R...
关键词：BIOSYNTHESIS Inhibitor LANOSTEROL Sterol methyltransferase Synthesis 
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