supported by the National Science Foundation for Excellent Young Scholars(32122052);National Natural Science Foundation Regional Innovation and Development(No.U19A2003);West China Hospital Postdoctoral Research and Development Fund(2023HXBH068);Guizhou Provincial Science and Technology Projects-ZK[2021]General 455.
The preferable antigen delivery profile accompanied by sufficient adjuvants favors vaccine efficiency.Mitochondria,which feature prokaryotic characteristics and contain various damage-associated molecular patterns(DAM...
supported by the National Natural Science Foundation of China(32200231);the Zhejiang Provincial Natural Science Foundation of China(LZ23C020002);the National Key Research and Development Program(2022YFD1401600)to RP;the National Science Foundation(MCB 2148206)to JH.
Besides providing energy to sustain life,mitochondria also play crucial roles in stress response and programmed cell death.The mitochondrial hallmark lipid,cardiolipin(CL),is essential to the maintenance of mitochondr...
Supported by grants from the Barth Syndrome Foundation to TF;the National Institutes of Health (R37 HL-64159) to RR. Mass spectrometry facility of Washington University is supported by NIH grants P41GM 103422,P30DK020579,P30DK056341, R21HL120760
Barth syndrome(BTHS) is a mitochondrial disorder characterized by cardiomyopathy and skeletal muscle weakness. Disease results from mutations in the tafazzin(TAZ) gene, encoding a phospholipid transacylase. Defect...
The processes of mitochondrial restitution are controlled by nuclear genes that encode proteins synthesized in ER and cytosol and delivered as organelle- and membrane-specific transport vesicles. The analysis of the t...
Project supported by the National Natural Science Foundation of China(Grant Nos.91227114;21322510;and 21105097);the China Postdoctoral Science Foundation(Grant No.2013M530998);the Natural Science Foundation of Jilin Province;China(Grant No.201215092);the President Funds of the Chinese Academy of Sciences
In this study, a lipid membrane was fabricated by fusing cardiolipin-phosphatidylcholine(CL_PC, 1:4) vesicles onto a hydrophobic surface of 1-dodecanethiol(DT) preadsorbed on a nanostructured gold film. By changi...
Supported by Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences,Internal Research Grant of University of Debrecen and the IOIBD Research Grant
AIM: To assess the prevalence and stability of different antiphospholipid antibodies(APLAs) and their association with disease phenotype and progression in inflammatory bowel diseases(IBD) patients.METHODS: About 458 ...
Nonalcoholic fatty liver disease(NAFLD) is today considered the most common form of chronic liver disease, affecting a high proportion of the population worldwide. NAFLD encompasses a large spectrum of liver damage, r...
We report a successful case of a pregnant female positive for anti-cardiolipin antibodies who experienced two abnormal pregnancies with postpartum cerebral hemispheric infarctions. A 38-year-old female diagnosed as be...
Phosphatidylglycerol (PG) an important membrane phospholipid required for the synthesis of diphos-phatidylglycerol (DPG) commonly known as cardiolipin (CL) was identified in the fraction of endo-plasmic reticulum (ER)...
Anti-phospholipid antibodies (APA) like anti-cardiolipin antibodies (ACA) and anti-β2glycoprotien (anti-β2GP) are important cause of venous and arterial thrombosis and other occlusive vascular diseases. The prevalen...