NICLOSAMIDE

作品数：9被引量：43H指数：4
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相关机构：山西医科大学中山大学镇江市疾病预防控制中心江苏大学更多>>
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钙结合蛋白S100A4抑制剂Niclosamide调节支气管上皮细胞炎症反应
《中国免疫学杂志》2024年第11期2262-2266,2272,共6页陈科 莫诗卉 晏世荣 李静 吴通前 余芳 
国家自然科学基金(82260324,81760294);贵州省科技厅项目(黔科合基础-ZK[2023]一般394,黔科合基础-ZK[2023]一般398)。
目的:研究钙结合蛋白S100A4抑制剂Niclosamide对支气管上皮细胞炎症反应的潜在调控机制。方法:体外培养人支气管上皮细胞BEAS-2B,给予LPS刺激或Niclosamide预处理,RT-qPCR、Western blot检测相关细胞因子和信号分子表达,荧光探针检测细...
关键词：支气管上皮细胞 LPS S100A4 NICLOSAMIDE ROS 紧密连接 炎症反应 
Repurposing niclosamide for the treatment of neurological disorders被引量：1
《Neural Regeneration Research》2023年第12期2705-2706,共2页Savina Apolloni Nadia D’Ambrosi 
“Re Nic ALS” grant from Ari SLA–Fondazione Italiana di ricerca per la SLA to SA。
Neurological disorders are still one of the major causes of death,and the vast need to find efficacious therapy is nowadays an essential goal of the scientific community.For Parkinson's disease(PD),amyotrophic lateral...
关键词：DISORDERS DEATH NEUROLOGICAL 
Niclosamide(NA)overcomes cisplatin resistance in human ovarian cancer被引量：6
《Genes & Diseases》2023年第4期1687-1701,共15页Linjuan Huang Jing Zhang Youling Deng Hao Wang Piao Zhao Guozhi Zhao Wei Zeng Yonghui Wang Connie Chen William Wagstaff Rex C.Haydon Russell R.Reid Tong-Chuan He Le Shen Hue H.Luu Ling Zhao 
supported in part by research grants from the National Institutes of Health(No.CA226303 to TCH,No.DE030480 to RRR);supported by the Medical Scientist Training Program of the National Institutes of Health(USA)(No.T32 GM007281);supported in part by The University of Chicago Cancer Center Support Grant(No.P30CA014599);the National Center for Advancing Translational Sciences of the National Institutes of Health(USA)(No.UL1 TR000430);supported by the Mabel Green Myers Research Endowment Fund and The University of Chicago Orthopaedics Alumni Fund.
Ovarian cancer(OC)is one of the most lethal malignancies of the female reproduc-tive system.OC patients are usually diagnosed at advanced stages due to the lack of early diag-nosis.The standard treatment for OC includ...
关键词：Chemotherapy resistance CISPLATIN Drug repurposing NICLOSAMIDE Ovarian cancer 
氯硝柳胺通过抑制S100A4表达减轻肝肺综合征病理性血管新生被引量：1
《陆军军医大学学报》2023年第11期1161-1172,共12页李才溢 李丹 杨从文 赖静 陈林 鲁开智 
国家自然科学基金面上项目(81671961);重庆市博士“直通车”科研项目(CSTB2022BSXM-JCX0006)。
目的探讨药物氯硝柳胺对S100A4的表达及大鼠肝肺综合征(hepatopulmonary syndrome,HPS)病理性血管新生的影响。方法30只雄性SD大鼠随机分为对照组(Sham组,n=6)、胆管结扎(common bile duct ligation,CBDL)组(CBDL组,n=18)和氯硝柳胺治疗...
关键词：肝肺综合征 S100A4 氯硝柳胺(Niclosamide) 胆管结扎 
Identification of niclosamide as a novel antiviral agent against porcine epidemic diarrhea virus infection by targeting viral internalization被引量：1
《Virologica Sinica》2023年第2期296-308,共13页Yue Wang Huimin Huang Dongliang Li Chenxu Zhao Shuai Li Panpan Qin Yaqin Li Xia Yang Wenjuan Du Wentao Li Yongtao Li 
supported by the National Natural Science Foundation of China(Grant No.31602033 and 32172839);the China Scholarship Council under grant 201908410129.
Porcine epidemic diarrhea virus(PEDV),an enteropathogenic coronavirus,has catastrophic impacts on the global pig industry.However,there remain no effective drugs against PEDV infection.In this study,we utilized a reco...
关键词：Coronavirus Porcine epidemic diarrhea virus(PEDV) Niclosamide(NIC) ANTIVIRAL Virus entry ENDOCYTOSIS Host-targeted antivirals 
Albumin-linked prostate-specific antigen-activated thapsigargin- and niclosamide-based molecular grenades targeting the microenvironment in metastatic castration-resistant prostate cancer被引量：2
《Asian Journal of Urology》2019年第1期99-108,共10页Emmanuel S.Akinboye W.Nathaniel Brennen Samuel R.Denmeade John T.Isaacs 
We would like to acknowledge the Prostate Cancer Foundation,Department of Defense Prostate Cancer Research Program(W81XWH-16-1-0410);NIH Prostate SPORE(P50 CA058236);Patrick C.Walsh Prostate Cancer Research Fund,and the Hopkins-Allegheny Health Network Cancer Research Fund。
Localized prostate cancer is curable via annihilation of the entire cancer neighborhood by surgery or local radiation.Unfortunately,once metastatic,no available therapy is curative.The vast majority will die despite a...
关键词：Albumin-linked prodrug Maleimide coupled albumin delivery THAPSIGARGIN NICLOSAMIDE 
Apropos:critical analysis of molluscicide application in schistosomiasis control programs in Brazil被引量：6
《Infectious Diseases of Poverty》2017年第1期470-474,共5页Hongjun Li Wei Wang 
This study was supported by the grant from Jiangsu Department of Health(grantno.Q201404).
Schistosomiasis is a snail-transmitted infectious disease affecting over 200 million people worldwide.Snail control has been recognized as an effective approach to interrupt the transmission of schistosomiasis,since t...
关键词：SCHISTOSOMIASIS Oncomelania hupensis MOLLUSCICIDE 26%suspension concentrate of metaldehyde and niclosamide 25%suspension concentrate of niclosamide ethanolamine salt 50%niclosamide ethanolamine salt wettable powder 4%niclosamide ethanolamine salt dustable powder 5%niclosamide ethanolamine salt granule Luowei 
Niclosamide,an old antihelminthic agent,demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells被引量：13
《Chinese Journal of Cancer》2012年第4期178-184,共7页Jing-Xuan Pan Ke Ding Cheng-Yan Wang 
supported in part by grants from National Natural Science Foundation of China for Distinguished Young Scholars(81025021);the National Basic Research Program of China(973Program grant2009CB825506);the Major Research Plan of the National Natural Science Foundation of China(90713036);the National High Technology Research and Development Program of China(863Program grant2008AA02Z420);the Fundamental Research Foundation for the Central Universities to Jing-Xuan Pan
Niclosamide,an oral antihelminthic drug,has been used to treat tapeworm infection for about 50 years.Niclosamide is also used as a molluscicide for water treatment in schistosomiasis control programs.Recently,several ...
关键词：抗肿瘤活性 氯硝柳胺 信号转导途径 干细胞 癌症 驱虫剂 显示 杀软体动物剂 
银杏外种皮对钉螺的杀灭机理被引量：13
《动物学报》2007年第1期190-194,共5页陈盛霞 吴亮 杨小明 姜旭淦 李龙根 张蓉仙 夏磊 邵世和 
江苏省社会发展基金资助项目(BS2005042)~~
To study the toxicity of extracts of Ginkgo biloba sarcotesta to Oncomelania hupensis,snails were exposed to 40% and 80% of 24 h LC 50 of the extract of Ginkgo bilba for 24 h,choline esterase(ChE),alanine aminotransfe...
关键词：Oncomelania hupensis Enzyme kinetic assay Sarcotesta of Ginkgo biloba ARECOLINE NICLOSAMIDE 
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