The Rh blood group system,especially the D antigen,is crucial in transfusion medicine and obstetrics.Weak D phenotypes,caused by mutations in the Rhesus D antigen(RhD)blood group(RHD)gene,result in reduced antigen exp...
supported by the ForTra gGmbH für Forschungstransfer der EKFS(2018_T20;2022_EKSE.41);A.M.and C.K.by the European Research Council(ERC,101141820 and 101021043);E.W.by the Leducq Foundation(Network 23CVD01).
In a recent study published in Cell,Ren and colleagues1 present a new rhesus macaque(Macaca mulatta)model for Duchenne muscular dystrophy(DMD)and a comprehensive single-cell analysis of skeletal muscle,providing detai...
Fetal hydrops can stem from immune or nonimmune causes.Immune causes often involve red cell alloimmunization,whereas nonimmune causes encompass structural malformations,aneuploidy,infections,lymphatic system disorders...
Background: The D antigen is the most important and immunogenic antigen of the Rh blood group;its correct screening prevents any risk of alloimmunization in the RHD negative recipient. The D negative phenotype is char...
supported by the Key-Area Research and Development Program of Guangdong Province(No.2019B030335001);the STI2030-Major Projects(No.2021ZD0200900);the National Key Research and Development Program of China(Nos.2021YFF0702700 and 2018YFA0801403);the National Natural Science Foundation of China(Nos.81960422,32100801,82101241,82360226,82160923,82260929,82374425,and 32460194);the Strategic Priority Research Program of the Chinese Academy of Sciences(CAS)(No.XDB32060200);the STI2030-Major Projects(Nos.2022ZD0205200 and 2022ZD0212700);the Science and Technology Department of Yunnan Province(Nos.202305AH340006 and 202305AH340007);the Yunnan Fundamental Research Projects(Nos.202201AT070153 and 202201AT070139);the Science and Technology Project of Yunnan Province(No.202101AY070001-001);the Yunnan Revitalization Talent Support Program(No.YNWR-QNBJ2019-043);the CAS“Light of West China”Program;the Yunnan Revitalization Talents Support Plan。
Complex brain diseases seriously endanger human health,and early diagnostic biomarkers and effective treatments are currently lacking.Due to ethical constraints on human research,establishing monkey models is crucial ...
supported by the National Key Research and Development Program of China (2022YFC2703302 to L.G.);the Youth Innovation Promotion Association of the Chinese Academy of Sciences (202000001l to L.G.);the Outstanding Youth Fund of the Chinese Academy of Sciences (31425015 to J.L.);the National Natural Science Foundation of China (81671516 to X.H.);the Basic and Applied Basic Research Foundation of Guangdong Province (2019B151502007 to T.Z.).
The prefrontal cortex(PFC)is essential for higher-level cognitive functions.How epigenetic dynamics participates in PFC development and aging is largely unknown.Here,we profiled epigenomic landscapes of rhesus monkey ...
Introduction: Perinatal mortality linked to fetal anemia of red cell alloimmunization in Côte d’Ivoire as in many developing countries can be explained by a lack of knowledge of Rhesus D feto-maternal alloimmunizatio...
supported by the National Key Research and Development Program of China(2022YFF0710901 to Q.S.);the National Natural Science Foundation of China(grants 31825018 and 82021001 toQ.S.;81827901 and 32170567 toG.W.);the ShanghaiMunicipal Science and Technology Major Project(2018SHZDZX05 to Q.S.and Z.Liu);the Biological Resources Program of the Chinese Academy of Sciences(KFJ-BRP-005);the Strategic Priority Research Programof the Chinese Academy of Sciences(XDB32060000 to Q.S.and Z.Liu);the Basic Frontier Scientific Research Program of the Chinese Academy of Sciences From 0 to 1 original innovation project(ZDBS-LY-SM019 to Z.Liu);the China National Postdoctoral Program for Innovative Talents(BX20200350 to Z.Lu).
Genomic imprinting can lead to allele-specific expression(ASE),where one allele is preferentially expressed more than the other.Perturbations in genomic imprinting or ASE genes have been widely observed across various...
Supported by grants from National Natural Science Foundation of China(No.81900891);Global Ophthalmology Awards Program 2020(No.482667)。
AIM:To evaluate the effect of miRNA-451 on rhesus macaque choroid-retinal endothelial(RF/6A)cell function and proteome profile.METHODS:The RF/6A cells were transfected with miRNA-451 mimic and inhibitor.The role of mi...
financially supported by the National Natural Science Foundation of China(Grant No.U1602224);the National Key Research and Development Program of China(2018YFA0107902 and 2016YFA0101401)。
Nonhuman primates(NHPs)present significant advantages over rodents for physiological and pharmacological investigations because of their higher genetic and physiological similarity to humans.