云南高校图书馆联盟文献共享服务平台- FASUDIL

FASUDIL: 作品数：53被引量：243H指数：9; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：马存根尉杰忠李艳花肖保国刘春云更多>>; 相关机构：山西大同大学复旦大学山西中医学院第二军医大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金山西省回国留学人员科研经费资助项目山西省国际科技合作计划山西省青年科技研究基金更多>>

Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis被引量：2: 《Neural Regeneration Research》2024年第3期671-679,共9页Chunyun Liu Shangde Guo Rong Liu Minfang Guo Qing Wang Zhi Chai Baoguo Xiao Cungen Ma; supported by a grant from the Department of Science and Technology of Shanxi Province,China,No.20210302123477(to CL);Datong Bureau of Science and Technology of China,No.2020152(to CL);the Opening Foundation of Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine,No.2022-KF-03(to CL).; Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous system.Macrophage polarization plays an important role in the pat...; 关键词：ANTI-INFLAMMATORY experimental autoimmune encephalomyelitis FASUDIL macrophage multiple sclerosis PRO-INFLAMMATORY Rho kinase

A SARS-CoV-2-specific CAR-T-cell model identifies felodipine,fasudil,imatinib,and caspofungin as potential treatments for lethal COVID-19: 《Cellular & Molecular Immunology》2023年第4期351-364,共14页in Xia Lun-zhi Yuan Ya-hong Hu Jun-yi Liu Guo-sheng Hu Ruo-yao Qi Tian-ying Zhang Hua-long Xiong Zao-zao Zheng Hong-wei Lin Jia-mo Zhang Chao Yu Ming Zhou Jian Ma Tong Cheng Ri-rong Chen Yi Guan Ning-shao Xia Wen Liu; Fundamental Research Funds for the Central Universities(20720200104)to LX;the Ministry of Science and Technology of China(2020YFA0112300 and 2020YFA0803600);the National Natural Science Foundation of China(82125028,U22A20320,91953114,31871319,81761128015,and 81861130370);the Natural Science Foundation of Fujian Province of China(2020J02004);the Fundamental Research Funds for the Central University(20720190145 and 20720220003)to WL;the China Postdoctoral Science Foundation(2022M720119)to ZZZ.Part of Fig.6 was drawnbyusingFigdraw.; Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-induced cytokine storm is closely associated with coronavirus disease 2019(COVID-19)severity and lethality.However,drugs that are effective against inflammat...; 关键词：COVID-19 SARS-CoV-2 CAR-T anti-inflammation NF-kB pathway

Fasudil在EAM小鼠中通过抑制NOTCH信号通路下调IL-6表达被引量：1: 《西安交通大学学报（医学版）》2023年第1期82-88,共7页李彦军王宇星杨嘉凯章培军李宛容张威刘杨青张年萍; 山西省基础研究计划青年项目(No.20210302123338);山西省高等学校科技创新项目(No.2021L372);山西省大学生创新创业训练计划项目(No.20220790);山西大同大学博士科研启动项目(No.2021019);山西大同大学大学生创新创业项目(No.XDC2021115)。; 目的探究法舒地尔(Fasudil)在实验性自身免疫性心肌炎(experimental autoimmune myocarditis,EAM)小鼠治疗中发挥的作用及机制,为临床上Fasudil治疗心肌炎提供理论依据。方法以Balb/c雄性小鼠为研究对象,使用MyHC-α614-629多肽构建EAM...; 关键词：法舒地尔实验性自身免疫性心肌炎 NOTCH信号通路 IL-6

Advantages of Rho-associated kinases and their inhibitor fasudil for the treatment of neurodegenerative diseases被引量：9: 《Neural Regeneration Research》2022年第12期2623-2631,共9页Qing Wang Li-Juan Song Zhi-Bin Ding Zhi Chai Jie-Zhong Yu Bao-Guo Xiao Cun-Gen Ma; supported by the National Natural Science Foundation of China, Nos.81473577 (to CGM), 81903596 (to QW), 82004028 (to LJS);China Postdoctoral Science Foundation, No.2020M680912 (to LJS);Open Project of The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, The Ministry of Education of China,No.2019004 (to CGM);Science and Technology Innovation Project of Shanxi Colleges of China, Nos.2019L0728 (to QW);Cultivation Project of Shanxi Universtity of Chinese Medicine of China, No.2019PY130 (to QW); Ras homolog(Rho)-associated kinases(ROCKs)belong to the serine-threonine kinase family,which plays a pivotal role in regulating the damage,survival,axon guidance,and regeneration of neurons.ROCKs are also involved in ...; 关键词：Alzheimer’s disease cell-based therapy central nervous system cells FASUDIL IMMUNOCYTES multiple sclerosis Parkinson’s disease PERICYTES Rho kinase inhibitor Rho-associated kinases

Shenqihuatan formula(参七化痰方) reduces inflammation by inhibiting transforming growth factor-beta-stimulated signaling pathway in airway smooth muscle cells被引量：1: 《Journal of Traditional Chinese Medicine》2022年第4期520-529,共10页CHEN Jingjing WANG Yuanyuan ZHANG Nianzhi XUE Xiaoming; Supported by the General Program of National Natural Science Foundation of China:Study on the Mechanism of the Method of Yiqi Huoxue Huata regulating autophagy in airway epithelial cells of COPD based on SIRT1/mTOR signaling pathway(No.82174312)and Study on the mechanism of the method of YIQI HUOXUE HUATA intervention in COPD airway remodeling based on RhoA/ROCK signaling pathway(No.81473675); OBJECTIVE:To study the effects and mechanism of Shenqihuatan formula(参七化痰方,SQHT)of the transforming growth factor-beta(TGF-β)-stimulated cell processes in airway remodeling.METHODS:The current study examined cel...; 关键词：pulmonary disease chronic obstructive transforming growth factor beta airway inflammation FASUDIL Shenqihuatan formula

法舒地尔通过抑制NogoA/NgR信号通路减轻H_(2)O_(2)诱导的SH-SY5Y人神经母细胞瘤细胞凋亡并增强突触可塑性被引量：1: 《细胞与分子免疫学杂志》2022年第7期625-631,共7页郭敏芳张慧宇于婧文章培军王玉银魏文悦宋丽娟柴智尉杰忠马存根; 山西省平台基地专项(201805D131005,201805D111009);山西省高等学校科技创新项目(2020L0484);大同市平台基地计划项目(2019198);神经炎症及变性疾病基础与应用研究山西省重点实验室开放课题(KF2019007);山西省卫健委医学科技领军团队(2020TD05);基于炎性反应的重大疾病创新药物山西省重点实验室项目(202105D121011);山西中医药大学青年科学家培育项目(2021-PY-QN-09)。; 目的探讨法舒地尔(Fasudil)对H(2)O_(2)诱导的SY5Y人神经母细胞瘤细胞凋亡和突触可塑性的影响及其机制。方法细胞分为PBS对照组、250μmol/L H(2)O_(2)处理组和250μmol/L H(2)O_(2)联合15μg/mL Fasudil处理组。噻唑蓝(MTT)法检测细胞...; 关键词：法舒地尔(Fasudil) 神经突生长抑制因子A(NogoA) Nogo受体(NgR) 细胞凋亡突触可塑性

Therapeutic potentials of fasudil in liver fibrosis: 《World Journal of Gastroenterology》2021年第45期7859-7861,共3页Yue Xi Peng-Fei Xu; Fasudil has the potential to prevent liver fibrosis by activating natural killer cells and inhibiting the proliferation of hepatic stellate cells.Fasudil may be a promising clinical therapeutic drug for the prevention...; 关键词：FASUDIL Liver fibrosis Natural killer cell Hepatic stellate cell Clinical therapeutic drug

Environmental enrichment combined with fasudil promotes motor function recovery and axonal regeneration after stroke被引量：9: 《Neural Regeneration Research》2021年第12期2512-2520,共9页Yi-Tong Zhu Qun Zhang Hong-Yu Xie Ke-Wei Yu Gao-Jing Xu Si-Yue Li Yi Wu; This study was supported by the National Natural Science Foundation of China,Nos.81672242(to YW),81972141(to YW);Shanghai Sailing Program,No.20YF1403500(to QZ);and Shanghai Municipal Key Clinical Specialty of China,No.shslczdzk02702(to YW).; Fasudil,a Rho-associated protein kinase(ROCK)inhibitor,has a protective effect on the central nervous system.In addition,environmental enrichment is a promising technique for inducing the recovery of motor impairments...; 关键词：axon regeneration biotinylated dextran amines environmental enrichment FASUDIL growth-associated protein 43 ischemic stroke motor recovery Nissl bodies Rho/ROCK pathway

Environmental enrichment combined with fasudil treatment inhibits neuronal death in the hippocampal CA1 region and ameliorates memory deficits被引量：2: 《Neural Regeneration Research》2021年第8期1460-1466,共7页Gao-Jing Xu Qun Zhang Si-Yue Li Yi-Tong Zhu Ke-Wei Yu Chuan-Jie Wang Hong-Yu Xie Yi Wu; financially supported by the National Natural Science Foundation of China,Nos. 81672242,81972141 (both to YW);Shanghai Municipal Key Clinical Specialty of China,No. shslczdzk02702 (to YW);Shanghai Special Support Plan for High-Level Talents,Yang Fan Funds of China,No. 20YF1403500 (to QZ)。; Currently, no specific treatment exists to promote recovery from cognitive impairment after a stroke. Dysfunction of the actin cytoskeleton correlates well with poststroke cognitive declines, and its reorganization re...; 关键词：cognitive environment HIPPOCAMPUS injury NEUROPROTECTION pathway repair STROKE

Fasudil prevents liver fibrosis via activating natural killer cells and suppressing hepatic stellate cells被引量：3: 《World Journal of Gastroenterology》2021年第24期3581-3594,共14页Qiu-Ju Han Yong-Liang Mu Hua-Jun Zhao Rong-Rong Zhao Quan-Juan Guo Yu-Hang Su Jian Zhang; Supported by The National Natural Science Foundation of China,No.81972694 and No.81972686.; BACKGROUND Fasudil,as a Ras homology family member A(RhoA)kinase inhibitor,is used to improve brain microcirculation and promote nerve regeneration clinically.Increasing evidence shows that Rho-kinase inhibition could...; 关键词：Liver fibrosis Natural killer cells FASUDIL Hepatic stellate cells

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