SEPIAPTERIN

作品数：3被引量：4H指数：1
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相关领域：农业科学更多>>
相关期刊：《Neuroscience Bulletin》《Acta Biochimica et Biophysica Sinica》《Biomedical and Environmental Sciences》更多>>
相关基金：国家自然科学基金更多>>
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Persistently Upregulated Hippocampal mTOR Signals Mediated by Fecal SCFAs Impair Memory in Male Pups with SMM Exposure in Utero
《Biomedical and Environmental Sciences》2019年第5期345-356,共12页ZHU Yi Tian LIU Xin Ji LIU Kai Yong ZHANG Qiang YANG Lin Sheng WEI Rong ZHANG Jing Jing TAO Fang Biao 
supported by the National Natural Science Foundation of China [81202209];Key Projects of Natural Science Research in Colleges and Universities of Anhui province [KJ2018A0164,KJ2017A189]
Objective To investigate the molecular mechanisms of the adverse effects of exposure to sulfamonomethoxin(SMM) in pregnancy on the neurobehavioral development of male offspring. Methods Pregnant mice were randomly div...
关键词：Cognitive deficits SULFAMONOMETHOXINE Short-chain fatty acids Mammalian target of rapamycin SEPIAPTERIN REDUCTASE 
Combining Human and Rodent Genetics to Identify New Analgesics被引量：3
《Neuroscience Bulletin》2018年第1期143-155,共13页Alban Latremoliere Michael Costigan 
supported by NIH grant DE022912;supported by NIH grant NS074430
Most attempts at rational development of new analgesics have failed, in part because chronic pain involves multiple processes that remain poorly understood. To improve translational success, one strategy is to select ...
关键词：Chronic pain GENETICS Mouse models TETRAHYDROBIOPTERIN Sepiapterin reductase ANALGESICS 
Role of Phe-99 and Trp-196 of sepiapterin reductase from Chlorobium tepidum in the production of L-threo-tetrahydrobiopterin被引量：1
《Acta Biochimica et Biophysica Sinica》2008年第6期513-518,共6页Supangat Sun Ok Park Kyung Hye Seo Sang Yeol Lee Young Shik Park Kon Ho Lee 
Sepiapterin reductase from Chlorobium tepidum （cSR） catalyzes the synthesis of a distinct tetrahydrobiopterin （BH4）, L-threo-BH4, different from the mammalian enzyme product. The 3-D crystal structure of cSR has r...
关键词：Chlorobium tepidum TETRAHYDROBIOPTERIN sepiapterin reductase site-directed mutagenesis ENZYME 
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