PIRNA

作品数：174被引量：268H指数：7
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piRNA 3′uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells
《Cell Research》2022年第11期1030-1033,共4页Mao-Zhou Zhao Di-Hang Lin Heng Zuo Huan Wei Xin Wang Lan-Tao Gou Mo-Fang Liu 
supported by the National Key R&D Program of China(2017YFA0504400,2021YFC2700200);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19010203);the National Natural Science Foundation of China(91940305,31830109,31821004,31961133022,91640201,32170815,32101037);Science and Technology Commission of Shanghai Municipality(17JC1420100,2017SHZDZX01,19JC1410200,21PJ1413800,21ZR1470200,21YF1452700,21ZR1470500);China Postdoctoral Science Foundation(2020T130670,2020M671256);the Foundation of Key Laboratory of Gene Engineering of the Ministry of Education.
Dear Editor,RNA tailing,i.e.,addition of non-templated nucleotides to the 3'endof RNAs,representsoneofthemostfrequent RNA modifications that participate in regulation of RNA processing,function,degradation,etc.^(1)PIW...
关键词：TEMPLATE FERTILITY indispensable 
An essential role for PNLDC1 in piRNA 3＇ end trimming and male fertility in mice被引量：4
《Cell Research》2017年第11期1392-1396,共5页Yue Zhang Rui Guo Yiqiang Cui Zhiping Zhu Yingwen Zhang Hao Wu Bo Zheng Qiuling Yue Shun Bai Wentao Zeng Xuejiang Guo Zuomin Zhou Bin Shen Ke Zheng Mingxi Liu Lan Ye Jiahao Sha 
This work was supported by the National Key R＆D Program of China （2016YFA0500902 and 2017YFA0103803）, the National Basic Research Program of China （2015CB943003）, National Natural Science Foundation of China Grant （81471502, 31771651, 31471228）, Excellent Youth Foundation of Jiangsu Scientific Committee（grant BK20150047）, and Innovative and Entrepreneurial Program of Jiangsu Province. We thank Jingdi Hu （Shanghai Biotechnology Corporation, Shanghai, China） for smalt RNA analysis.
Dear Editor, PIWI-interacting RNAs （piRNAs） are germ cell-specific small non-coding RNAs that are essential for silenc- ing transposable elements. Substantial efforts in the past decade have led to an understanding...
MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes被引量：38
《Cell Research》2015年第2期193-207,共15页Peng Zhang Jun-Yan Kang Lan-Tao GOU Jiajia Wang Yuanchao Xue Geir Skogerboe Peng Dai Da-Wei Huang Runsheng Chen Xiang-Dong Fu Mo-Fang Liu Shunmin He 
Acknowledgments We are grateful to Xiaole Shirley Liu and Jianhua Yang for thoughtful discussions and valuable comments on the manuscript. This work was supported by grants from the Ministry of Science and Technology of China （2011 CB504605 and 2014AA021103）, the National Natural Science Foundation of China （31090253, 31210103912, 31325008 and 91419307）, the Chinese Academy of Sciences （CAS; KJZD-EW-L01-2）, the Key Laboratory of the Zoological Systematics and Evolution of the Chinese Academy of Sciences （O529YX5105）, and the National Science Fund for Fostering Talents in Basic Research （Special subjects in animal taxonomy, NSFC-J1210002）. This work was also supported by NIH grants （GM052872 and HG004659）. The computing resource was supported by HPC Platform, Scientific Information Center, Institute of Zoology, CAS.
The piRNA machinery is known for its role in mediating epigenetic silencing of transposons. Recent studies suggest that this function also involves piRNA-guided cleavage of transposon-derived transcripts. As many piRN...
关键词：PIRNA MIWI SPERM 
piRNA biogenesis during adult spermatogenesis in mice is independent of the ping-pong mechanism被引量：7
《Cell Research》2012年第10期1429-1439,共11页Ergin Beyret Na Liu Haifan Lin 
piRNAs, a class of small non-coding RNAs associated with PIWI proteins, have broad functions in germline development, transposon silencing, and epigenetic regulation. In diverse organisms, a subset of piRNAs derived f...
关键词：MIWI MILL PIRNA ping-pong mechanism SPERMATOGENESIS MEIOSIS 
Regulation of small RNA stability： methylation and beyond被引量：14
《Cell Research》2012年第4期624-636,共13页Lijuan Ji Xuemei Chen 
Acknowledgments Studies from the Chen lab described in this article have been supported by grants from National Institutes of Health and National Science Foundation. We apologize to those whose work was not cited due to space constraints.
As central components of RNA silencing, small RNAs play diverse and important roles in many biological processes in eukaryotes. Aberrant reduction or elevation in the levels of small RNAs is associated with many devel...
关键词：miRNA SIRNA PIRNA METHYLATION HEN1 RNA silencing 
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