PRO-DRUG

作品数：7被引量：28H指数：4
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相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Neural Regeneration Research》《Asian Journal of Pharmaceutical Sciences》更多>>
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Photosensitive pro-drug nanoassemblies harboring a chemotherapeutic dormancy function potentiates cancer immunotherapy被引量：3
《Acta Pharmaceutica Sinica B》2023年第2期879-896,共18页Jianjun Cheng Haitian Zhao Bin Li Hua Zhang Qianyu Zhao Shiyao Fu Ying Han Weihong Lu Jiahua Shi Xin Yang 
the financial support from the National Natural Science Foundation of China(No.31972040,81760708);Jiangxi Provincial Natural Science Foundation Key Project(No.20192ACBL20028,China)。
Immunotherapy combined with effective therapeutics such as chemotherapy and photodynamic therapy have been shown to be a successful strategy to activate anti-tumor immune responses for improved anticancer treatment.Ho...
关键词：Cancer immunotherapy Nano-immunostimulants Chemotherapeutic dormancy PRO-DRUG Self-assembly Natural small molecule Betulinic acid Photodynamic therapy 
A glutathione activatable pro-drug-photosensitizer for combined chemotherapy and photodynamic therapy被引量：5
《Chinese Chemical Letters》2022年第10期4583-4586,共4页Yanjun Yang Yifeng Zhang Ran Wang Xiang Rong Ting Liu Xiang Xia Jiangli Fan Wen Sun Xiaojun Peng 
supported by the National Natural Science Foundation of China(Nos.22090011,22078046,21808028);NSFC Liaoning United Fund(No.U1908202)。
During cancer treatment,chemotherapeutic drugs always result in severe side-effects and drug resistance.Therefore,combining cheomtherapy with other therapeutic modalities,such as photodynamic therapy(PDT)and designing...
关键词：Pro-drug-photosensitizer CHEMOTHERAPY Photodynamic therapy GSH activation 
Emerging pro-drug and nano-drug strategies for gemcitabine-based cancer therapy被引量：5
《Asian Journal of Pharmaceutical Sciences》2022年第1期35-52,共18页Haijie Han Su Li Yueyang Zhong Yue Huang Kai Wang Qiao Jin Jian Ji Ke Yao 
supported by the Natural Science Foundation of China (Grant Nos. 52022090, 22005265, 82070739, 81870641);National Key R&D Program of China (Grant No. 2018YFC1106104);Key Research and Development Program of Zhejiang Province (Grant No. 2020C03035);Zhejiang Provincial Natural Science Foundation of China (Grant No. LQ20E030011);Zhejiang Medical Health Science and Technology Program (Grant No. 2021RC061);Zhejiang Provincial Ten Thousand Talents Program (2018R52001)。
Gemcitabine has been extensively applied in treating various solid tumors. Nonetheless,the clinical performance of gemcitabine is severely restricted by its unsatisfactory pharmacokinetic parameters and easy deactivat...
关键词：GEMCITABINE PRO-DRUG Nano-drug Cancer therapy 
Conversion and pharmacokinetics profiles of a novel pro-drug of 3-n-butylphthalide, potassium 2-（1-hydroxypentyl）-benzoate, in rats and dogs被引量：10
《Acta Pharmacologica Sinica》2018年第2期275-285,共11页Jiang LI Shao-feng XU Ying PENG Nan FENG Ling WANG Xiao-liang WANG 
Potassium 2-（1-hydroxypentyl）-benzoate （d/-PHPB） is a novel pro-drug of 3-n-butylphthalide （dkNBP） that is used to treat ischemic stroke. Currently, dl-PHPB is in phase II-III clinical trials in China. In this s...
关键词：potassium 2-（1-hydroxypentyl）-benzoate （dl-PHPB） PRO-DRUG 3-n-butylphthalide （dFNBP） ischemic stroke PHARMACOKINETICS bioavailability 
Effect of HX0507,a water-soluble propofol pro-drug,on subarachnoid hemorrhage-induced cerebral vasospasm in rabbits
《Neural Regeneration Research》2009年第11期890-895,共6页Xinsheng Xue Tao Zhu Wensheng Zhang Yan Kang Jin Liu 
BACKGROUND： Propofol has been shown to attenuate neuronal injury in a number of experimental conditions. However, its effect in models of cerebral ischemia after subarachnoid hemorrhage （SAH） remains controversial....
关键词：HX0507 subarachnoid hemorrhage basilar artery vasospasm 
Inhibition of human gastric carcinoma cell growth by atofluding derivative N_3-o-toluyl-fluorouracil被引量：5
《World Journal of Gastroenterology》2006年第42期6766-6770,共5页Jian Liu Wen-Fang Xu Shu-Xiang Cui Yong Zhou Yun-Xia Yuan Ming-Hui Chen Ruo-Han Wang Ruo-Yan Gai Masatoshi Makuuchi Wei Tang Xian-Jun Qu 
Supported by National Natural Science Foundation of China, No.30472038; Department of Science and Technology of Shandong Province, China and Japan-China Medical Association
AIM： To evaluate the growth inhibition efficacy of atofluding derivative N3-o-toluyl-fluorouracil （TFU） on human gastric carcinoma cell lines SGC-7901 and MKN-45. METHODS： Cell growth inhibition by TFU was measure...
关键词：N3-o-toluyl-fluorouracil Gastric carcinoma cells PRO-DRUG Growth inhibition 
Total Syntheses of 16a’-Homoleurosidine and 16a’-Homovinblastine
《合成化学》2004年第z1期21-21,共1页Martin E. Kuehne 
关键词：TOTAL synthesis  VINBLASTINE analogue  conformational equilibrium  ANTI-CANCER pro-drug. 
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