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Landscapes of gut microbiome and blood metabolomic signatures in relapsing remitting multiple sclerosis
《Science China(Life Sciences)》2025年第4期1042-1056,共15页Jinzhou Feng Shi Tang Xiaolin Yang Mengjie Zhang Zhizhong Li Shaoru Zhang Yongliang Han Yongmei Li Philippe P.Monnier Gang Yu Peng Zheng Cunjin Zhang Ke Xu Xinyue Qin 
supported by the National Science Foundation of China (81701191, 82301720);Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0973, CSTB2023NSCQMSX0183, CSTB2023NSCQ-BHX0214);China Postdoctoral Science Foundation (2022M722384, 2023MD734128);the Joint Project of Chongqing Health Commission and Science and Technology Bureau (2020FYYX104);Chongqing Postdoctoral Special Support Foundation (2023CQBSHTB2010);Chongqing Postdoctoral Science Foundation (CSTB2023NSCQ-BHX0214);the First Affiliated Hospital of Chongqing Medical University Postdoctoral Science Foundation (CYYY-BSHPYXM-202310);CQMU Program for Youth Innovation in Future Medicine (W0168)。
Although disturbances in the gut microbiome have been implicated in multiple sclerosis(MS), little is known about the changes and interactions between the gut microbiome and blood metabolome, and how these changes aff...
关键词：relapsing remitting multiple sclerosis gut microbiota 16S rRNA gene sequence untargeted metabolomics lipid metabolism biomarker 
Investigation of the genome-wide signatures underlying the micropapillary carcinoma components in colorectal cancers
《Genes & Diseases》2025年第2期94-97,共4页Yingying Meng Zhao Zhang Tao Tang Yanhong Yu Dan Wang Wei Sun 
funded by the National Natural Science Foundation of China (No.32370820,81772976);Tianjin Science and TechnologyFunding (China) (No.21JCYBJC00300);the Key Project of Traditional Chinese Medicine of Tianjin Health Commission (No.2022006).
The invasive micropapillary carcinoma(MPC)is a rare and specialized pathologic subtype of cancer.MPCs are highly aggressive,highly metastatic,and commonly associated with poor prognosis.MPC components have been found ...
关键词：BLADDER MORPHOLOGICAL STOMACH 
Machine learning algorithms reveal gut microbiota signatures associated with chronic hepatitis B-related hepatic fibrosis
《World Journal of Gastroenterology》2025年第16期30-48,共19页Ying Zhu Shi-Yu Geng Yao Chen Qing-Jing Ru Yi Zheng Na Jiang Fei-Ye Zhu Yong-Sheng Zhang 
Supported by the Zhejiang Provincial Natural Science Foundation,No.LZ22H270001.
BACKGROUND Hepatic fibrosis(HF)represents a pivotal stage in the progression and potential reversal of cirrhosis,underscoring the importance of early identification and therapeutic intervention to modulate disease tra...
关键词：Chronic hepatitis B virus infection Hepatic fibrosis Liver stiffness Fecal microbiomes Serum intestinal mucosal barrier 
Signatures of non-Euclidean metrics in the optical features of microcavities
《Science China(Physics,Mechanics & Astronomy)》2025年第4期265-266,共2页Hans-Jürgen Stöckmann 
Starting with the nineties of the last century disc-shaped dielectric cavities have received a lot of attention because of their interest in the design of micro-lasers and integrated optics applications[1-5].The light...
关键词：DIELECTRIC Euclidean OPTICS 
Observational signatures of traversable wormholes
《Chinese Physics C》2025年第4期295-306,共12页Yiqian Chen Lang Cheng Peng Wang Haitang Yang 
Supported in part by the the National Natural Science Foundation of China(12105191,12275183,12275184,11875196)。
This study investigates the observational signatures of traversable Simpson-Visser wormholes illuminated by luminous celestial spheres and orbiting hot spots.We demonstrate that when light sources and observers are on...
关键词：gravitational lensing WORMHOLE ASTROMETRY 
Extreme genetic signatures of local adaptation in a notorious rice pest,Chilo suppressalis
《National Science Review》2025年第3期24-38,共15页Yan Peng Kaikai Mao Hongran Li Junfen Ping Jingyun Zhu Xinye Liu Zhuting Zhang Minghui Jin Chao Wu Nan Wang Alexander Yesaya Kenneth Wilson Yutao Xiao 
funded by the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences(CAAS-ZDRW202412);the Sci-Tech Innovation 2030 Agenda(2022ZD04021);Shenzhen Science and Technology Program(KQTD20180411143628272);funded by the UK’s BBSRC(BB/P023444/1)and YtX/KW by a UK Newton International Fellowship(NIF\R1\191106);the UK-China collaboration benefitted from funding from a UK BBSRC China-UK Partnering Award(BB/L026821/1).
Climatic variation stands as a significant driving force behind genetic differentiation and the evolution of adaptive traits.Chilo(C.)suppressalis,commonly known as the rice stem borer,is a highly destructive pest tha...
关键词：local adaptation Chilo suppressalis gene flow cold tolerance 
Unlocking the healthy human microbiome:Redefining core microbial signatures
《Acta Pharmaceutica Sinica B》2025年第2期1189-1192,共4页Shuting Xi Diya Jiang Qianyi Zhou Hairong Lyu Anita Y.Voigt Xin Zhou Zhemin Zhou Yuan Huang 
supported by the National Natural Science Foundation of China(Nos.82300345,3217003,32370099,and 81901287);the National High-Level Hospital Clinical Research Funding(2023-GSP-QN-23,China);the Provincial-level Talent Program for National Center of Technology Innovation for Biopharmaceuticals(NCTIB2024JS0101,China);the Suzhou Top-Notch Talent Groups(ZXD2022003,China).
Despite the enormous progress made in microbiome research,a comprehensive and universally accepted framework for identifying healthy microbiome biomarkers remains elusive.Defining what constitutes a"healthy"gut microb...
关键词：Gut health GUILDS BIOMARKER Causal inference 
Genome-wide circular RNAs signatures involved in sexual maturation and its heterosis in chicken
《Journal of Integrative Agriculture》2025年第2期697-711,共15页Yuanmei Wang Jingwei Yuan Yanyan Sun Aixin Ni Jinmeng Zhao Yunlei Li Panlin Wang Lei Shi Yunhe Zong Pingzhuang Ge Shixiong Bian Hui Ma Jilan Chen 
funded by the National Natural Science Foundation of China(32172721);the China Agriculture Research System(CARS-40);the Central Publicinterest Scientific Institution Basal Research Fund,China(2021-YWF-ZYSQ-12);the Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences(ASTIP-IAS04)。
Sexual maturation heterosis has been widely exploited in animal crossbreeding.However,the underlying mechanism has been rarely explored in chicken.In the present study,we performed the reciprocal crossing between Whit...
关键词：CHICKEN sexual maturation HETEROSIS OVARY circRNA 
Genetic feature diversity of KRAS-mutated colorectal cancer and the negative association of DNA mismatch repair deficiency relevant mutational signatures with prognosis
《Genes & Diseases》2025年第1期102-105,共4页Ruichuan Shi Yu Cheng Jin Wang Na Song Ying Chen Zan Teng Ling Xu Yunpeng Liu Xiaotian Zhao Qiuxiang Ou Peng Yang Rui Ma Yiting Sun Jinglei Qu Xiujuan Qu 
supported by grants from the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2017ZX09304025);the Technological Special Project of Liaoning Province,China(No.2019020176-JH1/103);the High-level innovation and entrepreneurship team of Liaoning province's"Xing Liao Talents Program"(No.XLYC2008006).
KRAS mutations occur in approximately 40%of metastatic colorectal cancer(CRC),leading to disrupted hydrolysis of guanosine triphosphate and tumor cell proliferation.1 Genetic features and clinical outcomes of CRCs dep...
关键词：KRAS COLORECTAL PROGNOSIS 
In silico analysis of lncRNA-miRNA-mRNA signatures related to Sorafenib effectiveness in liver cancer cells
《World Journal of Gastroenterology》2025年第3期84-102,共19页Patricia de la Cruz-Ojeda Ester Parras-Martínez Raquel Rey-Pérez Jordi Muntané 
Supported by Instituto de Salud Carlos III(ISCiii),No.PI19/01266 and No.PI22/00857;Consejería de Salud y Familias(Junta de Andalucía),No.PI-0216-2020 and No.PIP-0215-2020;Biomedical Research Network Center for Liver and Digestive Diseases(CIBERehd)founded by the ISCIII and co-financed by European Regional Development Fund“A way to achieve Europe”ERDF.
BACKGROUND Hepatocellular carcinoma(HCC)is the most common subtype of primary liver cancer with varied incidence and epidemiology worldwide.Sorafenib is still a recommended treatment for a large proportion of patients...
关键词：Cell culture Hepatocellular carcinoma Non-coding RNA RNASEQ SORAFENIB 
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