MEMBRANELESS

作品数：22被引量：19H指数：3
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Membraneless organelles in health and disease:exploring the molecular basis,physiological roles and pathological implications
《Signal Transduction and Targeted Therapy》2024年第12期5513-5538,共26页Yangxin Li Yuzhe Liu Xi-Yong Yu Yan Xu Xiangbin Pan Yi Sun Yanli Wang Yao-Hua Song Zhenya Shen 
supported by the National Natural Science Foundation of China(82370264 to Y.Li,82370501 to Y.H.S.,81870194 and 91849122 to Y.Li,92168203 to Z.S.);Project of State Key Laboratory of Radiation Medicine and Protection,Soochow University(No.GZK12023023 to Y.Li);Jiangsu Cardiovascular Medicine Innovation Center(CXZX202210);China Postdoctoral Science Foundation(No.2021M702394 to Y.W.);Jiangsu Funding Program for Excellent Postdoctoral Talent(No.2022ZB578 to Y.W.);The project for the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);The National Key Research and Development Program of China(2022YFE0209700)to X.Y.Translational Research Grant of NCRCH(2020WSB07).
Once considered unconventional cellular structures,membraneless organelles(MLOs),cellular substructures involved in biological processes or pathways under physiological conditions,have emerged as central players in ce...
关键词：METABOLISM apparatus PHYSIOLOGICAL 
Biomolecular condensates and disease pathogenesis
《Science China(Life Sciences)》2024年第9期1792-1832,共41页Ke Ruan Ge Bai Yanshan Fang Dan Li Tingting Li Xingguo Liu Boxun Lu Qing Lu Zhou Songyang Shuguo Sun Zheng Wang Xin Zhang Wen Zhou Hong Zhang 
supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0480000);the National Key Research and Development Program of China(2022YFA1103800,2022YFA1303100,2023YFE0210100);the National Natural Science Foundation of China(22337005,22377119,32025010,32241002,32270812,32270920,32325016,32350024,32261160376,82150003,82188101,82325016,92157202,92254301,T2325003);STI2030-Major Projects(2021ZD0202501);the Science and Technology Commission of Shanghai Municipality(2019SHZDZX02,20490712600);the Key Research Program CAS(ZDBS-ZRKJZ-TLC003);International Cooperation Program CAS(154144KYSB20200006);CAS Project for Young Scientists in Basic Research(YSBR-075);Guangdong Province Science and Technology Program(2023B1111050005,2023B1212060050);Natural Science Foundation of Anhui Province(2108085J12);Center for Advanced Interdisciplinary Science and Biomedicine of IHM(QYPY20220008);Shenzhen Talent Program(KQTD20210811090115021);Guangdong Innovative and Entrepreneurial Research Team Program(2021ZT09Y104)。
Biomolecular condensates or membraneless organelles(MLOs)formed by liquid-liquid phase separation(LLPS)divide intracellular spaces into discrete compartments for specific functions.Dysregulation of LLPS or aberrant ph...
关键词：liquid-liquid phase separation biomolecular condensate membraneless organelle 
Multiple roles of arsenic compounds in phase separation and membraneless organelles formation determine their therapeutic efficacy in tumors
《Journal of Pharmaceutical Analysis》2024年第8期1110-1124,共15页Meiyu Qu Qiangqiang He Hangyang Bao Xing Ji Tingyu Shen Muhammad Qasim Barkat Ximei Wu Ling-Hui Zeng 
the financial support from the National Natural Science Foundation of China(Grant Nos.:31571493,81741043,31871395,and 32170841).
Arsenic compounds are widely used for the therapeutic intervention of multiple diseases.Ancient pharmacologists discovered the medicinal utility of these highly toxic substances,and modern pharmacologists have further...
关键词：Arsenic compounds Phase separation Membraneless organelles PML Stress granules 
ZW10:an emerging orchestrator of organelle dynamics during the cell division cycle
《Journal of Molecular Cell Biology》2024年第7期1-11,共11页Sm Faysal Bellah Fengrui Yang Fangyuan Xiong Zhen Dou Xuebiao Yao Xing Liu 
supported by grants from the Ministry of Science and Technology of China and the National Natural Science Foundation of China(2022YFA1303100,32090040,92254302,2022YFA0806800,W2411017,32450537,91953000,92153302,32170733,and 22177106);Plans for Major Provincial Science&Technology Projects of Anhui Province(202303a0702003);the Ministry of Education(IRT_17R102);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19040000);the Fundamental Research Funds for the Central Universities(KB9100000007,KB9100000006,and KB9100000013).
Zeste white 10(ZW10)was first identified as a centromere/kinetochore protein encoded by the ZW10 gene in Drosophila.ZW10 guides the spindle assembly checkpoint signaling during mitotic chromosome segregation in metazo...
关键词：ZW10 KINETOCHORE membrane-bound organelle membraneless organelle MITOSIS 
Microfluidic fuel cells integrating slanted groove micro-mixers to terminate growth of depletion boundary layer thickness
《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》2023年第10期859-874,共16页Jinchi SUN Xiongwei TIAN Zhangqing LIU Jie SUN Menglian ZHENG 
supported by the National Natural Science Foundation of China(No.51606164).
Because of potential high energy densities,microfluidic fuel cells can serve as micro-scale power sources.Because microfluidic fuel cells typically operate in the co-laminar flow regime to enable a membrane-less desig...
关键词：Microfluidic Fuel cell MEMBRANELESS Slanted groove micro-mixer Mass transfer Depletion boundary layer 
Predicting assembly mode of membraneless organelles by a FRET-based crowding sensor
《Signal Transduction and Targeted Therapy》2023年第7期3225-3227,共3页Feng Chen Siyuan Shen Xu Cao Liang Zhang Lunxu Liu Daoke Yang Yunyu Shi Wei He Xuebiao Yao Dan Liu 
This work was jointly supported by grants from the National Natural Science Foundation of China(32090041,D.L.);the Major Research Plan of the National Natural Science Foundation of China(2016YFA0101200,D.L.).This work was also supported in part by the CAS Key Laboratory of Innate Immunity and Chronic Disease.We are grateful to Prof.Yucai Wang and Prof.Chunlei Cang for providing experimental instruments and equipments,especially confocal microscopes.We appreciate Prof.Wei Xiong and Dr.Yushu Ge for their help and advice in the process of writing this letter.We thank Mr.Zhao Yue for his help in the data processing process.We also thank our colleagues Ms.Yun Wang,Ms.Mengtong Qin and Ms.Yu Chen for their help during the experiment.
Dear Editor,Biomacromolecules aggregate to form membraneless organelles(MLOs)via phase separation has been observed in a variety of physiological processes over the last decade.1 However,the molecular basis of biomacr...
关键词：SEPARATION methods MODE 
Phase-separated bienzyme compartmentalization as artificial intracellular membraneless organelles for cell repair
《Science China Chemistry》2023年第3期845-852,共8页Yanwen Zhang Shixin Wang Yuling Yan Xiaoxiao He Zefeng Wang Shaohong Zhou Xiaohai Yang Kemin Wang Jianbo Liu 
supported by the National Natural Science Foundation of China(21735002,22177032,32101082);the Science Fund for Distinguished Young Scholars of Hunan Province(2021JJ10013);the Hunan Province Innovative Talent Funding for Postdoctoral Fellows(2021RC2059);the Postdoctoral Science Foundation of China(2021TQ0103,2021M690957).
Implanting artificial organelles in living cells is capable of correcting cellular dysfunctionalities for cell repair and biomedical applications. In this work, phase-separated bienzyme-loaded coacervate microdroplets...
关键词：artificial membraneless organelles coacervate microdroplets nitric oxide liquid-liquid phase separation cell repair 
Induction of membraneless organelles as a strategy for HIV-1 post-nuclear entry steps
《Journal of Molecular Cell Biology》2023年第2期1-2,共2页Sheng Zhou Hongyu Deng 
As intracellular parasites,viruses must modulate the environment of host cells to facilitate viral genome replication and virion assembly.One strategy is to establish specialized,membrane-associated subcellular struct...
关键词：al. STEPS utilized 
Molecular determinants for the layering and coarsening of biological condensates
《Aggregate》2022年第6期113-121,共9页Andrew P.Latham Bin Zhang 
National Science Foundation,Grant/Award Number:MCB-2042362;National Institute of General Medical Sciences,Grant/Award Number:R35GM133580。
Many membraneless organelles,or biological condensates,form through phase separation,and play key roles in signal sensing and transcriptional regulation.While the functional importance of these condensates has inspire...
关键词：biological condensate intrinsically disordered protein membraneless organelle phase separation surface tension 
HIV-induced membraneless organelles orchestrate post-nuclear entry steps被引量：1
《Journal of Molecular Cell Biology》2022年第11期9-23,共15页Viviana Scoca Renaud Morin Maxence Collard Jean-Yves Tinevez Francesca Di Nunzio 
funded by the ANRS REACTing grant(ECTZ88162)with a nominative PhD student fellowship(ECTZ88177)for V.S.;the Sidaction/Fondation pour la Recherche Médicale(FRM)grant(VIH20170718001);Institut Pasteur.
HIV integration occurs in chromatin sites that favor the release of high levels of viral progeny;alternatively, the virus is alsoable to discreetly coexist with the host. The viral infection perturbs the cellular envi...
关键词：HIV nuclear condensates nuclear remodelling phase separation reverse transcription 
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