BACKGROUND Skeletal muscle alterations(SMAs)are being increasingly recognized in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD)and appear to be associated with deleterious outcomes in the...
supported by grants from the National Key Research and Development Program of China(2018YFA0800403 and 2021YFC2701903);the Training Program of the Major Research Plan of the National Natural Science Foundation of China(91857110);the National Natural Science Foundation of China(81670740,32000817,82100904,and 82300910);the National Natural Science Fund for Excellent Young Scholars of China(81722012);the Zhejiang Provincial Natural Science Foundation of China(LZ21H070001,LHDMD22H02001,and LHDMD24H030001);the Innovative Institute of Basic Medical Sciences of Zhejiang University,and the Fundamental Research Funds for the Central Universities.
Skeletal muscle plays a vital role in the regulation of systemic metabolism,partly through its secretion of endocrine factors which are collectively known as myokines.Altered myokine levels are associated with metabol...
This work was supported by grants from the Canadian Institutes for Health Research(MOP-81392);the Kidney Foundation of Canada,the Heart and Stroke Foundation of Canada,Russian Foundation for Fundamental Research(15-04-00101);the Russian Scientific Foundation(14-15-00006);Research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number UL1TR000430(N.O.D).
During the last two decadesnumerous research teams demonstratedthat skeletalmuscles function as an exercise-dependent endocrine organ secreting dozens of myokines.Variety of physiological and pathophysiological implic...