CASCADE

作品数:779被引量:1389H指数:14
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Synthesis of fluorescent multisubstituted polyquinolines by cascade C–H activation-based polyannulations of isonicotinamides and diynes
《Science China Chemistry》2023年第4期1139-1149,共11页Dongyang Fan Fei Zhang Jie Cui Dong Wang Ting Han Ben Zhong Tang 
supported by the National Natural Science Foundation of China(22271197,21905176);the Natural Science Foundation for Distinguished Young Scholars of Guangdong Province(2020B1515020011);the Science and Technology Plan of Shenzhen(JCYJ20190808142403590,JCYJ20190808153415062);the Instrumental Analysis Center of Shenzhen University。
The development of new and efficient polymerization strategies for the synthesis of multisubstituted fused heterocyclic polymers with attractive properties is of great significance.Herein,a rhodium-catalyzed polyannul...
关键词:fused heterocyclic polymers polyannulation POLYQUINOLINES aggregation-induced emission BIOIMAGING 
Dynamic assembly and biocatalysis-selected gelation endow self-compartmentalized multienzyme superactivity
《Science China Chemistry》2022年第10期1985-1993,共9页Yue Liao Xia Wang Hongdou Shen Ziyang Tai Qigang Wang 
supported by the National Science Fund for Distinguished Young Scholars (52125305);the National Natural Science Foundation of China (51873156,52173289);the Shanghai Science and Technology Committee (20dz1101200);the key project of the first demonstration project (Artificial Intelligence) of interdisciplinary joint research of Tongji University (ZD-11-202151)
Cellular metabolism in multiple organelles utilizes compartmentalized multienzyme efficient catalysis to realize substance metabolism, energy conversion and immune defenses. The convenient and biomimetic design of art...
关键词:HYDROGEL cascade enzyme enzymatic polymerization COMPARTMENTALIZATION superactivity 
Theranostic nanosystem mediating cascade catalytic reactions for effective immunotherapy of highly immunosuppressive and poorly penetrable pancreatic tumor被引量:1
《Science China Chemistry》2022年第7期1383-1400,共18页Gengjia Chen Yujun Cai Bo Li Minzhao Lin Xiaobin Wang Zhiyong Wang Xintao Shuai 
supported by the National Natural Science Foundation of China (51933011, 31971296);the Key Areas Research and Development Program of Guangzhou (202007020006, 2019B020235001);the Natural Science Foundation of the Guangdong Province (2021A1515011799);the Opening Project of State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University (201922);the Science and Technology Project of Yantian District in Shenzhen City, Guangdong Province, China (20190106)。
The dense desmoplastic stroma and immunosuppressive microenvironment of pancreatic cancer hinder the penetration of drugs and induce a considerable resistance to conventional chemoradiotherapy. Although nanomedicine h...
关键词:nanozyme catalytic cascade reactions MACROPHAGES tumor microenvironment nitric oxide 
Catalytic chemodivergent annulations betweenα-diketones and alkynylα-diketones
《Science China Chemistry》2021年第6期991-998,共8页Xiangwen Kong Fang Yu Zhizhou Chen Fan Gong Shuang Yang Jinggong Liu Benlong Luo Xinqiang Fang 
This work was supported by the National Natural Science Foundation of China(21871260,22071242);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB20000000);Fujian Natural Science Foundation(2018J05035);the China Postdoctoral Science Foundation(2018M630734);the Science and Technology Research Program of the Education Department of Jiangxi Province(GJJ1991151).
Four types of unprecedented and chemodivergent reactions betweenα-diketones and alkynylα-diketones have been achieved under the catalysis of phosphine and Br?nsted base,respectively,leading to the rapid construction...
关键词:chemodivergent reaction cascade annulation phosphine catalysis rearrangement reaction fluorescent material 
Framework nucleic acid-based confined enzyme cascade for efficient synergistic cancer therapy in vivo
《Science China Chemistry》2021年第4期660-665,共6页Gezhi Kong Meng Zhang Mengyi Xiong Mei Chen Chan Yang Yan Zhao Yue Yang Zilong Zhao Zhi-Ling Song Liang Gong Guoliang Ke Xiao-Bing Zhang Weihong Tan 
supported by the National Natural Science Foundation of China(21705038,21705043,21890744,21705037,21521063);the National Key R&D Program of China(2019YFA0210100);Natural Science Foundation of Hunan Province(2018JJ3029,2018JJ3092);China Postdoctoral Science Foundation(2020M672470);the Open Funding Project of Shandong Key Laboratory of Biochemical Analysis(QUSTHX201808)。
Artificial enzyme cascade systems with confinement effect are highly important in synthetic biology and biomedicine.Herein,a framework nucleic acid-based confined enzyme cascade(FNA-CEC)for synergistic cancer therapy ...
关键词:DNA nanotechnology DNA nanostructures drug delivery enzyme cascade cancer therapy 
Express and sensitive detection of multiple miRNAs via DNA cascade reactors functionalized photonic crystal array
《Science China Chemistry》2020年第5期731-740,共10页Yingfei Wang Yuyi Li Yue Zhang Kewei Ren Huangxian Ju Ying Liu 
supported by the National Natural Science Foundation of China(21635005,21605083,21974064);the National Research Foundation for Thousand Youth Talents Plan of China,Specially-appointed Professor Foundation of Jiangsu Province,Program for innovative Talents and Entrepreneurs of Jiangsu Province。
Array based detection techniques with fluorescence signal reading is a powerful tool for multiple targets analysis. However,when applied fluorescence array for micro RNA detection, time-consuming multi-steps surface s...
关键词:micro RNA detection photonic crystal array DNA cascade reactors fluorescence amplification express detection 
Radical cascade reactions of unsaturated C–C bonds involving migration被引量:2
《Science China Chemistry》2019年第11期1476-1491,共16页Ge Zhang Yang Liu Jinbo Zhao Yan Li Qian Zhang 
supported by the National Natural Science Foundation of China(21831002,21801039);Ten Thousand Talents Program,the Jilin Province Natural Science Foundation(20160519003JH);the Fundamental Research Funds for the Central Universities(2412018QD007)
During the past few years, with the rapid development of mild methods for the generation of radical species, great progress in radical cascade reactions of unsaturated C–C bonds has been made. Many radical cascade re...
关键词:RADICAL CASCADE reaction functional group MIGRATION UNSATURATED C–C BONDS C-centered RADICALS N-centered RADICALS 
Ruthenium (II)-catalyzed synthesis of phthalides via the cascade addition and cyclization of aromatic acids with aldehydes
《Science China Chemistry》2018年第2期153-158,共6页Juan Fan Peng-Min Wang Jia-Ni Wang Xue Zhao Zhong-Wen Liu Jun-Fa Wei Xian-Ying Shi 
supported by the National Science Foundation of China (21572122, 21376146);Shaanxi Innovative Team of Key Science and Technology (2013KCT-17);the Fundamental Research Funds for the Central Universities (GK201703019, GK 201601005)
The ruthenium-catalyzed intermolecular cascade cyclization of aromatic acids with aromatic aldehydes, which involves the direct insertion of C–H bond into a polar C=O bond and the successive intramolecular nucleophil...
关键词:nucleophilic addition cascade cyclization ruthenium 3-substituted phthalides C–H activation 
An efficient synthesis of isocoumarins via a CuI catalyzed cascade reaction process被引量:1
《Science China Chemistry》2009年第10期1616-1621,共6页WANG LeiLei ZHANG XiaoJing JIANG YongWen MA DaWei 
Supported by the National Natural Science Foundation of China (Grant Nos. 20621062 & 20872156)
3-Alkyl isocoumarins are provided by CuI/amino acid-catalyzed Sonogashira coupling reaction of o-bromo benzoic acids and terminal alkynes and the subsequent additive cyclization. This cascade process allows synthesis ...
关键词:coupling CASCADE REACTION copper IODIDE ISOCOUMARINS 
Photon cascade emission of Pr^(3+) in LnBaB_9O_(16)(Ln=La,Y)被引量:2
《Science China Chemistry》2001年第1期1-6,共6页杨智 林建华 苏勉曾 
the Youth Scientist Excellency Foundation (Grant No. 29625101), National Natural Science Foundation of China (Grant No. 29731010), Rhodia Rare Earth Co., the State Key Basic Research Program and Education Committee Foundation of Yunnan Province (Grant No
Under 216 nm UV-excitation, cascade emission of Pr3+ occurs from1S0 state in LaBaB9O16:Pr3+ that converts a single UV photon of high energy into two visible photons. The observation of the cascade emission in this oxi...
关键词:rare earth borate photon cascade luminescence Pr3+ 
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