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Unveiling the hidden battlefield:dissecting the invasive zone in liver cancer
《Cell Research》2023年第9期651-652,共2页Valerie Chew 
Understanding the tumor ecosystem,particularly the tumor invasive margins,is crucial for studying tumor progression and metastasis.Using nanoscale-resolution SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),Wu...
关键词：INVASIVE CANCER al. 
Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids被引量：6
《Cell Research》2023年第9期661-678,共18页Zongyong Ai Baohua Niu Yu Yin Lifeng Xiang Gaohui Shi Kui Duan Sile Wang Yingjie Hu Chi Zhang Chengting Zhang Lujuan Rong Ruize Kong Tingwei Chen Yixin Guo Wanlu Liu Nan Li Shumei Zhao Xiaoqing Zhu Xuancheng Mai Yonggang Li Ze Wu Yi Zheng Jianping Fu Weizhi Ji Tianqing Li 
This work was supported by the National Key R&D Program of China(2022YFA1103100 and 2021YFA0805700);the National Natural Science Foundation of China(32130034,82192874,32100655 and 82160294);the National Key R&D Program of China(2020YFA0112700);the Major Basic Research Project of Science and Technology of Yunnan(202102AA100007,202001BC070001 and 2019FY002);the Joint Special Funds for the Department of Science and Technology of Yunnan Province‑Kunming Medical University(202101AY070001-260 and 202301AY070001-298).
Studies of cultured embryos have provided insights into human peri-implantation development.However,detailed knowledge of peri-implantation lineage development as well as underlying mechanisms remains obscure.Using 3D...
关键词：IMPLANTATION architectures INSIGHT 
Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses被引量：11
《Cell Research》2021年第7期742-757,共16页Jian He Jing Yan Jianfang Wang Liangyu Zhao Qian Xin Yang Zeng Yuxi Sun Han Zhang Zhijie Bai Zongcheng Li Yanli Ni Yandong Gong Yunqiao Li Han He Zhilei Bian Yu Lan Chunyu Ma Lihong Bian Heng Zhu Bing Liu Rui Yue 
supported by grants from the National Key R&D Program of China(2017YFA0106400,2017YFA0103401,2016YFA0100601 and 2019YFA0110201);the National Natural Science Foundation of China(31425012,31871173,31930054,81772389,81800102,81890991,81900115,82070108,91749124 and 81871771);the Fundamental Research Funds for the Central Universities(22120190149,22120200411,kx0200020173386);the Program for Guangdong Introducing Innovative and Entrepreneurial Teams(2017ZT07S347);the Beijing Municipal Science and Technology Commission(Z171100000417009);the Beijing Natural Science Foundation(7182123);the State Key Laboratory of Proteomics(SKLP-K201502);the Key R&D Program of Guangdong Province(2019B020234002).
Human skeletal stem cells(SSCs)have been discovered in fetal and adult long bones.However,the spatiotemporal ontogeny of human embryonic SSCs during early skeletogenesis remains elusive.Here we map the transcriptional...
关键词：SKELETAL EPITHELIUM landscape 
Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution被引量：3
《Cell Research》2021年第4期463-477,共15页Li Li Lin Li Qingqing Li Xixi Liu Xinyi Ma Jun Yong Shuai Gao Xinglong Wu Yuan Wei Xiaoye Wang Wei Wang Rong Li Jie Yan Xiaohui Zhu Lu Wen Jie Qiao Liying Yan Fuchou Tang 
The study was supported by the Beijing Advanced Innovation Center for Genomics at Peking University;We sincerely thank Fei Wang and Xuefang Zhang from the National Center for Protein Sciences Beijing(Peking University)for assisting with the FACS analysis;Part of the bioinformatic analyses were run on the Computing Platform of the Center for Life Science;The study was supported by the Beijing Municipal Science and Technology Commission(Z181100001318001);the National Natural Science Foundation of China(31625018,31890781,81521002 and 81730038);the National Basic Research Program of China(2018YFA0107601,2018YFC1004000 and 2017YFA0102702).
Proper development of fetal germ cells(FGCs)is vital for the precise transmission of genetic and epigenetic information through generations.The transcriptional landscapes of human FGC development have been revealed;ho...
关键词：FETAL PRECISE LANDSCAPE 
Dissecting the bone marrow HSC niches
《Cell Research》2016年第9期975-976,共2页Meng Zhao Linheng Li 
Hematopoietic stem cells （HSCs） sponsoring hematopoiesis arc preserved in the bone marrow （BM） microenvironment or niche. Here, Itkin et al. demonstrate how distinct blood vessels contribute to HSC maintenance and...
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