Supported by the Key Project Plan of Health and Medical Science Research in Hebei Provincial Health Commission,No.20190745.
BACKGROUND Plasma concentration monitoring is crucial for optimizing vancomycin use,particularly in patients in the intensive care unit(ICU).However,the reference interval for vancomycin plasma concentration remains u...
Clostridium difficile infection(CDI)has been increasing due to the effect of recurrent hospitalizations.The use of antibiotics has been shown to alter the gut microbiome and lead to CDIs.The treatment is limited to th...
Purpose:The role of topical vancomycin in fracture-related infection(FRI)is debatable.Very few studies have reported their efficacy in open and high-risk extremity fractures.This study aimed to assess topical vancomyc...
Background: The 2020 consensus guidelines recommend AUC guided dosing as the preferred monitoring method for vancomycin. AUC based dosing has shown to reduce incidence of acute kidney injury (AKI), utilize lower daily...
funded as a key clinical project of Peking University Third Hospital [No. BYSY2018021];funded by Beijing Natural Science Foundation [7212128]。
Objective This study aimed to evaluate the clinical benefits of a vancomycin dosage strategy based on a serum trough concentration model in elderly patients.Methods This prospective single-center, open-label, randomiz...
Background:Shunt systems are used to provide cerebrospinal fluid drainage in the treatment of hydrocephalus.Recently,antibiotic-impregnated shunt systems are used to prevent colonization in the ventriculoperitoneal ca...
Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is a global superbug widely distributed in hospitals, communities and livestock settings. This study investigated the presence and molecular characterizat...
supported by the Scientific Research and Development Fund of the Beijing University of Chinese Medicine(2180072120047);by the Tibetan medicine Collaborative Innovation Fund (5040071620003)
Objective: To explore the effects of the extract of Sanchen powder(ESCP) combined with vancomycin on methicillin-resistant Staphylococcus aureus(MRSA) planktonic cells, biofilms, and virulence factors.Methods: The her...
Supported by the Hebei Natural Science Foundation of China,No.H2019206614。
BACKGROUND Vancomycin is the most commonly used drug for methicillin-resistant Staphylococcus aureus.The empirical clinical doses of vancomycin based on non-obese patients may not be optimal for obese ones.CASE SUMMAR...
BACKGROUND Surgical site infection is a rare but serious complication associated with total joint arthroplasty(TJA).There are limited data on the effectiveness of intrawound irrigation with vancomycin solution(1000 mg...