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  • 期刊=Synthetic and Systems Biotechnologyx
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Efficient conversion of aromatic and phenylpropanoid alcohols to acids by the cascade biocatalysis of alcohol and aldehyde dehydrogenases
《Synthetic and Systems Biotechnology》2024年第2期187-195,共9页Zetian Qiu Xiaohui Liu Jie Yu Yushuo Zhao Guang-Rong Zhao Shengying Li Kun Liu Lei Du Li Ma 
This work was supported by the National Key Research and Development Program of China(2021YFA0911500);the National Natural Science Foundation of China(32071266,32170088,and 32370032);the Shandong Provincial Natural Science Foundation(ZR2020ZD23);the State Key Laboratory of Microbial Technology Open Projects Fund(M2022-01).
Benzyl and phenylpropanoid acids are widely used in organic synthesis of fine chemicals,such as pharmaceuticals and condiments.However,biocatalysis of these acids has received less attention than chemical synthesis.On...
关键词：Benzyl acids Phenylpropanoid acids Alcohol dehydrogenases Aldehyde dehydrogenases Whole-cell catalysis 
Efficient biosynthesis of creatine by whole-cell catalysis from guanidinoacetic acid in Corynebacterium glutamicum
《Synthetic and Systems Biotechnology》2024年第1期99-107,共9页Chunjian Li Pengdong Sun Guoqing Wei Yuqi Zhu Jingyuan Li Yanfeng Liu Jian Chen Yang Deng 
funded by National Natural Science Foundation of China(no.32272279);the Key R&D project of Qingdao Science and Technology Plan(22-3-3-hygg-29-hy).
Creatine is a naturally occurring derivative of an amino acid commonly utilized in functional foods and pharmaceuticals.Nevertheless,the current industrial synthesis of creatine relies on chemical processes,which may ...
关键词：CREATINE Corynebacterium glutamicum Whole-cell biocatalysis Guanidinoacetate N-Methyltransferase Food additive 
Artificial multi-enzyme cascades and whole-cell transformation for bioconversion of C1 compounds: Advances, challenge and perspectives
《Synthetic and Systems Biotechnology》2023年第4期578-583,共6页Yangyi Qiao Wenyue Ma Shangjie Zhang Feng Guo Kang Liu Yujia Jiang Yanxia Wang Fengxue Xin Wenming Zhang Min Jiang 
supported by National Key R&D Program of China(2022YFC2105900);the National Natural Science Foundation of China(22078151,22378199,21978130);Jiangsu Natural Science Fund for Distinguished Young Scholars(BK20220052)the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture(XTD2215);Young Elite Scientist Sponsorship Program by CAST(YESS20200174).
Artificial multi-enzyme cascades bear great potential for bioconversion of C1 compounds to value-added chemicals.Over the past decade,massive efforts have been devoted to constructing multi-enzyme cascades to produce ...
关键词：SCALING PROOF utilizing 
Efficient stereoselective hydroxylation of deoxycholic acid by the robust whole-cell cytochrome P450 CYP107D1 biocatalyst被引量：1
《Synthetic and Systems Biotechnology》2023年第4期741-748,共8页Chixiang Sun Baodong Hu Yanchun Li Zhimeng Wu Jingwen Zhou Jianghua Li Jian Chen Guocheng Du Xinrui Zhao 
supported by the National Key Research and Development Program of China(2019YFA0906400);the National First-class Discipline Program of Light Industry Technology and Engineering(LITE2018-08);Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_2486);We thank Prof.Shengying Li(Shandong University,China)for providing plasmids pET28a-SelFdx1499 and pET28a-SelFdR0978.
Deoxycholic acid(DCA)has been authorized by the Federal Drug Agency for cosmetic reduction of redundant submental fat.The hydroxylated product(6β-OH DCA)was developed to improve the solubility and pharmaceutic proper...
关键词：OleP Deoxycholic acid HYDROXYLATION Redox partners Whole-cell catalysis 
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