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作品数：49被引量：59H指数：4
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Efficient conversion of aromatic and phenylpropanoid alcohols to acids by the cascade biocatalysis of alcohol and aldehyde dehydrogenases
《Synthetic and Systems Biotechnology》2024年第2期187-195,共9页Zetian Qiu Xiaohui Liu Jie Yu Yushuo Zhao Guang-Rong Zhao Shengying Li Kun Liu Lei Du Li Ma 
This work was supported by the National Key Research and Development Program of China(2021YFA0911500);the National Natural Science Foundation of China(32071266,32170088,and 32370032);the Shandong Provincial Natural Science Foundation(ZR2020ZD23);the State Key Laboratory of Microbial Technology Open Projects Fund(M2022-01).
Benzyl and phenylpropanoid acids are widely used in organic synthesis of fine chemicals,such as pharmaceuticals and condiments.However,biocatalysis of these acids has received less attention than chemical synthesis.On...
关键词：Benzyl acids Phenylpropanoid acids Alcohol dehydrogenases Aldehyde dehydrogenases Whole-cell catalysis 
Artificial multi-enzyme cascades and whole-cell transformation for bioconversion of C1 compounds: Advances, challenge and perspectives
《Synthetic and Systems Biotechnology》2023年第4期578-583,共6页Yangyi Qiao Wenyue Ma Shangjie Zhang Feng Guo Kang Liu Yujia Jiang Yanxia Wang Fengxue Xin Wenming Zhang Min Jiang 
supported by National Key R&D Program of China(2022YFC2105900);the National Natural Science Foundation of China(22078151,22378199,21978130);Jiangsu Natural Science Fund for Distinguished Young Scholars(BK20220052)the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture(XTD2215);Young Elite Scientist Sponsorship Program by CAST(YESS20200174).
Artificial multi-enzyme cascades bear great potential for bioconversion of C1 compounds to value-added chemicals.Over the past decade,massive efforts have been devoted to constructing multi-enzyme cascades to produce ...
关键词：SCALING PROOF utilizing 
Efficient stereoselective hydroxylation of deoxycholic acid by the robust whole-cell cytochrome P450 CYP107D1 biocatalyst被引量：1
《Synthetic and Systems Biotechnology》2023年第4期741-748,共8页Chixiang Sun Baodong Hu Yanchun Li Zhimeng Wu Jingwen Zhou Jianghua Li Jian Chen Guocheng Du Xinrui Zhao 
supported by the National Key Research and Development Program of China(2019YFA0906400);the National First-class Discipline Program of Light Industry Technology and Engineering(LITE2018-08);Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_2486);We thank Prof.Shengying Li(Shandong University,China)for providing plasmids pET28a-SelFdx1499 and pET28a-SelFdR0978.
Deoxycholic acid(DCA)has been authorized by the Federal Drug Agency for cosmetic reduction of redundant submental fat.The hydroxylated product(6β-OH DCA)was developed to improve the solubility and pharmaceutic proper...
关键词：OleP Deoxycholic acid HYDROXYLATION Redox partners Whole-cell catalysis 
Optimization of Two-species Whole-cell Immobilization System Constructed with Marine-derived Fungi and Its Biological Degradation Ability被引量：5
《Chinese Journal of Chemical Engineering》2014年第2期187-192,共6页陈慧英 王明霞 沈煜斌 姚善泾 
Supported by the National Natural Science Foundation of China(21036005);Scientific Technology Program of Zhejiang Province(2011C33016)
Mycelia pellet formed spontaneously in the process of cultivation was exploited as a biological carrier for whole-cell immobilization due to its unique structural characteristic. An innovative two-species whole-cell i...
关键词：whole-cell immobilization mycelia pellet Pestalotiopsis sp. Penicillium janthinellum biodegradation kinetics biological wastewater treatment 
AIIocryptopine and benzyltetrahydropalmatine block hERG potassium channels expressed in HEK293 cells被引量：5
《Acta Pharmacologica Sinica》2013年第6期847-858,共12页Kun LIN Yu-qi LIU Bin XU Jin-liao GAO Yi-cheng FU Yu CHEN Qiao XUE Li YANG 
This study was supported by grants from the National Natural Science Foundation of China （No 81170177, No 30770901）. The authors would like to thank Prof Silvia G PRIORI from Molecular Cardiology, Fondazione Salvatore Maugeri IRCCS, at the University of Pavia in Italy for generously providing the hERG plasmid.
Aim： AIIocryptopine （ALL） is an alkaloid extracted from Corydalis decumbens （Thunb） Pers. Papaveraceae, whereas benzyltetrahydropalmatine （BTHP） is a derivative of tetrahydropalmatine extracted from Corydalis a...
关键词：allocryptopine benzyltetrahydropalmatine hERG current whole-cell patch-clamp recording anti-arrhythmic agent 
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