REDESIGN

作品数：54被引量：48H指数：4
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Design and redesign journey of a drug for transthyretin amyloidosis
《Neural Regeneration Research》2025年第4期1096-1097,共2页Francisca Pinheiro Salvador Ventura 
funded by the Spanish Ministry of Science and Innovation(PDC2021-120914-I00);the Universitat Autònoma de Barcelona(PROOF OF CONCEPT 2020);ICREA,ICREA-Academia 2015 and 2020(to SV).
The misfolding and subsequent aggregation of proteins into amyloid fibrils underlie the onset of a variety of human disorders collectively known as amyloidosis.Transthyretin(TTR)is one of the>30 amyloidogenic proteins...
关键词：AMYLOID aggregation SENILE 
AlphaFold-guided redesign of a plant pectin methylesterase inhibitor for broad-spectrum disease resistance被引量：1
《Molecular Plant》2024年第9期1344-1368,共25页Yeqiang Xia Guangzheng Sun Junhua Xiao Xinyi He Haibin Jiang Zhichao Zhang Qi Zhang Kainan Li Sicong Zhang Xuechao Shi Zhaoyun Wang Lin Liu Yao Zhao Yuheng Yang Kaixuan Duan Wenwu Ye Yiming Wang Suomeng Dong Yan Wang Zhenchuan Ma Yuanchao Wang 
supported bythe National Key Research and Development Program of China(2022YFF1001500);the National Natural Science Foundation of China(32102172)and(31721004);the China National Postdoctoral Program for Innovative Talents(BX2021130);the China Postdoctoral Science Foundation(2021M700074).
Plant cell walls are a critical site where plants and pathogens continuously struggle for physiological domi-nance.Here we show that dynamic remodeling of pectin methylesterification of plant cell walls is a compo-nen...
关键词：apoplastic immunity AlphaFold-guided redesign broad-spectrum disease resistance pectin methyl-esteraseinhibitor cell wall 
KinasePhos 3.0:Redesign and Expansion of the Prediction on Kinase-specific Phosphorylation Sites
《Genomics, Proteomics & Bioinformatics》2023年第1期228-241,共14页Renfei Ma Shangfu Li Wenshuo Li Lantian Yao Hsien-Da Huang Tzong-Yi Lee 
The authors express their gratitude toward all database developers mentioned and quoted in this article for their important work and the data they shared.The author also would like to thank users for their comments and suggestions on the previous version of KinasePhos.This work was supported by the National Natural Science Foundation of China(Grant No.32070659);the Science,Technology and Innovation Commission of Shenzhen Municipality(Grant No.JCYJ20200109150003938);the Guangdong Province Basic and Applied Basic Research Fund(Grant No.2021A1515012447);the Ganghong Young Scholar Development Fund(Grant No.2021E007),China.This work is supported by the Warshel Institute for Computational Biology funding from Shenzhen City and Longgang District,China.
The purpose of this work is to enhance KinasePhos,a machine learning-based kinasespecific phosphorylation site prediction tool.Experimentally verified kinase-specific phosphorylation data were collected from PhosphoSi...
关键词：Kinase-specific phosphorylation Phosphorylation site prediction PHOSPHORYLATION SHAP feature importance KINASE 
An Ergonomics Study and Rapid Upper Limb Assessments(RULA)for a Car Interior to Support Limb Disabled Drivers
《Journal of Management Science & Engineering Research》2022年第2期17-30,共14页Salami Bahariah Suliano Siti Azfanizam Binti Ahmad Azizan As’arry Faieza Abdul Aziz 
The demanding market shows that the need for the disabled vehicles have been increasing over the recent years.However,these factory setting cars are pricey,and its buy-sell process is time-consuming.These cars also ar...
关键词：Limbs disabled REDESIGN Inclusive design ERGONOMICS RULA 
Redesign Facility Layout with a Kaizen Approach in Testing Laboratory at Balai Pengujian&Sertifikat Mutu Barang Makassar
《Journal of Management Science & Engineering Research》2022年第2期31-37,共7页A.Dwi Wahyuni P Ahmad Padhil Mashur Ramadhan A.Pawennari 
In trading activities,especially exports in the food commodities sector,several documents must be made and completed by exporters,such as Certificate of Quality,Test-Certificate,and Chemical Analysis.Balai Pengujian&S...
关键词：Facilities layout 5S Conventional layout planning Laboratory layout 
Middle/Small Sized Cities and Open Spaces. Technological-Environmental Design Synergies
《Journal of Civil Engineering and Architecture》2022年第2期78-84,共7页Filippo Angelucci Cristiana Cellucci 无 
The paper presents some of the results of research carried out by the authors on the unbuilt spaces of small and medium-sized towns,which are characterised by demographic and economic fragility,as well as by critical ...
关键词：Technological-environmental design user centred vision universal centred vision urban redesign regulating-enabling space 
Three-Dimensional Optimal Guidance with Lyapunov Redesign for UAV Interception被引量：1
《Guidance, Navigation and Control》2021年第4期64-82,共19页Chang Yu Bing Zhu Zongyu Zuo 
supported by the National Natural Science Foundation of China under Grant No.62073015.
Three-dimensional guidance laws are designed to intercept non-maneuvering targets and maneuvering targets in this paper.An optimal control approach with constant or time-variant feedback gain is proposed for intercept...
关键词：Optimal guidance Lyapunov redesign maneuvering target 
Study and Redesign of Aircooler System in a 16 MW Steam Turbine Surface Condenser at Neka Power Plant
《Journal of Power and Energy Engineering》2021年第7期61-75,共15页Edris Ghonoodi Mofid Gorji Bandpy 
According to the
《Journal of Textile Science and Technology》2021年第1期41-54,共14页Rowena Fatchu Kansanba Vincentia Okpattah Mercy Ampofowah Osei Solomon Marfo Ayesu Abraham Ekow Asmah 
Kaba is considered to be a kind of traditional apparel worn by the women in Ghana. Though, it’s worn to accentuate female modesty, chastity and elegance among the women folks. The modern day woman faces a lo...
关键词：Kaba Ensemble REDESIGN Breastfeeding Mothers Effective Breastfeeding 
Redesigned Duplex RT-qPCR for the Detection of GI and GII Human Noroviruses被引量：2
《Engineering》2020年第4期442-448,共7页Danlei Liu Zilei Zhang Qingping Wu Peng Tian Haoran Geng Ting Xu Dapeng Wang 
supported by the Ministry of Science and Technology of China(2017YFC1601200);the National Natural Science Foundation of China(31772078);the Agri-X Interdisciplinary Fund of Shanghai Jiao Tong University(2017).
Human noroviruses(HuNoVs)are major foodborne pathogens that cause nonbacterial acute gastroenteritis worldwide.As the tissue-culture system for HuNoVs is not mature enough for routine detection of the virus,detection ...
关键词：Human noroviruses RT-QPCR REDESIGN Primer Probe DETECTION 
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