supported by the National Natural Science Foundation of China(U1202261,U1602263).
Techniques of reduced-representation sequencing(RRS)have revolutionized ecological and evolutionary genomics studies.Precise establishment of orthologs is a critical challenge for RRS,especially when a reference genom...
Most plants are polyploid due to whole-genome duplications (WGD) and can thus have duplicated genes. Following a WGD, paralogs are often fractionated (lost) and few duplicate pairs remain. Little attention has bee...
supported by a grant from the National Natural Science Foundation of China(Grant No.31571355 and 31301034);supported by Fudan University,China;Iowa State University,United States
Side effects from targeted drugs remain a serious conccrn. One reason is the nonselective binding of a drug to unintended proteins such as its paralogs, which arc highly homologous in sequences and have similar struct...
Dear Editor,Plant senescence is an integral part of plant development, with old organs senescing in association with the emergence and development of nascent ones. Rapid chlorophyll (Chl) degradation, the most promi...
supported by the National Natural Science Foundation of China (Grant Nos. 3093002 and 30870046 to Shen YuLong,and 30700011 to Sheng DuoHong);the Promotive Research Fund for Excellent Young and Middle-aged Scientists of Shandong Province (Grant No. BS2010SW014 to Sheng DuoHong)
Rad51/RadA paralogs found in eukaryotes and euryarchaea play important roles during recombination and repair,and mutations in one of the human Rad51 paralogs,Rad51C,are associated with breast and ovarian cancers.The h...
supported by Ministry of Science and Technology(2007CB947201);Chinese Academy of Sciences (XDA01010108);National Science Foundation of China (30425013)to J.Z.
Nogo-A is a major myelin associated inhibitor that blocks regeneration of injured axons in the central nervous system (CNS). Nogo-66 (a 66-residue domain of Nogo-A) expressed on the surface of oligodendrocytes has...
the National Natural Science Foundation of China (Nos. 30470354 and 30570356);the Program for New Century Ex-cellent Talent in Universities (NCET);the Program for Changji-ang Scholars and Innovative Research Teams in Universities
Adiponectin is one of the hormones secreted exclusively by the adipose tissue with anti-diabetic anti-inflammatory, anti-atherogenic, anti-atherosclerotic, and insulin-sensitizing effects. Adiponectin has structural f...
Supported by the National Basic Research Program of China (Grant No. 2004CB719604);National Natural Science Foundation of China (Grant Nos. 30470386 and 30700011)
ST0838 (designed stRad55B) is one of the four RadA paralogs (or Rad55 homologues) in the genome of the hyperthermophilic crenarchaeon Sulfolobus tokodaii. The gene is induced by UV irradiation, sug-gesting that it is ...