相关期刊:《Transactions of Nonferrous Metals Society of China》《应用与环境生物学报》《Crystal Structure Theory and Applications》《Chinese Journal of Chemical Engineering》更多>>
supported by the Danish Council of Independent Research (DFF-0602-02196, DFF-4181-00274, DFF-1323-00330);the Fundamental Research Funds for the Central Universities (2662015PX199)
Archaea represents the third domain of life, with the information-processing machineries more closely resembling those of eukaryotes than the machineries of the bacterial counterparts but sharing metabolic pathways wi...
supported by the grants from the National Natural Science Foundation of China (Nos. 3093002, 31170072 and 31470184 to Y.S.)
In archaea, the HEL308 homolog Hel308a(or Hjm) is implicated in stalled replication fork repair. The biochemical properties and structures of Hjm homologs are well documented, but in vivo mechanistic information is ...
Exodeoxyribonuclease III (EXOIII) acts as a 3’→5’ exonuclease and is homologous to purinic/apyrimidinic (AP) endonuclease (APE), which plays an important role in the base excision repair pathway. To structurally in...
supported by the grants from the National Natural Science Foundation of China(Nos.3093002 and 31170072) to Y.S;Danish Council of Independent Research(No.FTP/11-106683) to Q.S
RecA family recombinases play essential roles in maintaining genome integrity. A group of RecA-like proteins named RadC are present in all archaea, but their in vivo functions remain unclear. In this study, we perform...
supported by the National Natural Science Foundation of China (Grant Nos. 3093002 and 30870046 to Shen YuLong,and 30700011 to Sheng DuoHong);the Promotive Research Fund for Excellent Young and Middle-aged Scientists of Shandong Province (Grant No. BS2010SW014 to Sheng DuoHong)
Rad51/RadA paralogs found in eukaryotes and euryarchaea play important roles during recombination and repair,and mutations in one of the human Rad51 paralogs,Rad51C,are associated with breast and ovarian cancers.The h...
Supported by the National Natural Science Foundation of China (31070042,30870039,30921065);partially by Open Funding Project of the National Key Laboratory of Biochemical Engineering,China (2010KF-2)
The thermostability of three sulfur oxygenase reductases (SORs) was investigated from thermoacidophilic achaea Acidianus tengchongensis (SORAT) and Sulfolobus tokodaii (SORsT) as well as the moderately thermophi...
supported by the National Natural Science Foundation of China(Nos.30921065,30730003 and 30870058) to L.Huang;the Danish Research Council for Technology and Production(No.274-07-0116)
Topoisomerase III (topo III), a type IA topoisomerase, is widespread in hyperthermophilic archaea. In order to interrogate the in vivo role of archaeal topo III, we constructed and characterized a topo III gene dele...