sponsored by National Key R and D Program of China(2023YFD1201002);the Key Research and Development Projects of Shannxi Province(2022NY-125).
Metalloproteinases are ubiquitous in organisms.Most metalloproteinases secreted by pathogenic microorganisms are also called virulence factors,because they degrade proteins in the external tissues of the host,thereby ...
The authors sincerely acknowledge the financial support from the National Natural Science Foundation of China(52302343);Beijing Institute of Technology Teli Young Fellow Program(RCPT-20220029);the Beijing Institute of Technology Research Fund Program for Young Scholars(XSQD-6120220130,XSQD-202213001).
The emergence of multidrug-resistant bacteria poses a significant challenge in the treatment of osteomyelitis,rendering traditional antibiotic treatment strategies inadequate in terms of achieving a complete cure.In r...
supported by grants from the National Natural Science Foundation of China (32172374;31721004);the China Agriculture Research System (CARS-004-PS14)。
Plants can be infected by multiple pathogens concurrently in natural systems. However,pathogen–pathogen interactions have rarely been studied. In addition to the oomycete Phytophthora sojae, fungi such as Fusarium sp...
Pathogens have developed an extensive array of proteins during the co-evolutionary arms race with their hosts.This is particularly true for Phytophthora,a genus that causes significant damage to agriculture and forest...
supported by the National Natural Science Foundation of China (31721004, 32001882);the Natural Science Foundation of Jiangsu Province (BK20190520);the Fundamental Research Funds for the Central Universities (KJQN202109)。
The oomycete pathogen Phytophthora sojae is a causal agent of soybean root rot.Upon colonization of soybeans,P.sojae secretes various RXLR effectors to suppress host immune responses,supporting successful infection.Pr...
supported by grants from the Chinese National Science Fund(32130088,31972252);C.G.has been supported by grants from the Chinese National Science Fund(32102234);National Postdoctoral Program for Innovative Talents(BX2021131);the China Postdoctoral Science Foundation(2020M681644).
Alternative splicing(AS)regulation of pre-mRNA has been proven to be one of the fundamental layers of plant immune system.How pathogens disrupt plant AS process to suppress plant immunity by secreted effectors remain ...
The Shigella flexneri effector IpaH7.8 targets gasdermin B for degradation in infected host cells.This bacterial strategy counteracts a host defense mechanism in which the lymphoid cell compartment activates the bacte...
Both parasitology and stem cell research are important disciplines in their own right.Parasites are a real threat to human health causing a broad spectrum of diseases and significant annual rates morbidity and mortali...
the National Key Research and Development Program of China(Grant Nos.2017YFA0505900 and 2017YFD0500300);the National Basic Research Programs of China(Grant No.2014CB74440);the National Natural Science Foundation of China(Grant Nos.81371769 and 81571954);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDPB03);the Youth Innovation Promotion Association CAS(Grant No.Y12A027BB2).
The major innate immune cell types involved in tuberculosis(TB)infection are macrophages,dendritic cells(DCs),neutrophils and natural killer(NK)cells.These immune cells recognize the TB-causing pathogen Mycobacterium ...
Recognition of pathogens by their hosts is the result of a highly regulated interaction between both host and pathogen elicitors. Therefore, mechanical defence lead to an increase in the production of substances capab...