GENOME-WIDE

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Genome-wide DNA methylation landscape of four Chinese populations and epigenetic variation linked to Tibetan high-altitude adaptation
《Science China(Life Sciences)》2023年第10期2354-2369,共16页Zeshan Lin Yan Lu Guoliang Yu Huajing Teng Bao Wang Yajun Yang Qinglan Li Zhongsheng Sun Shuhua Xu Wen Wang Peng Tian 
the National Key Research and Development Program of China(2016YFC0900402);the Basic Science Center Program(32288101);the National Natural Science Foundation of China(32030020 and 31961130380);the Shanghai Municipal Science and Technology Major Project(2017SHZDZX01)。
DNA methylation(DNAm)is one of the major epigenetic mechanisms in humans and is important in diverse cellular processes.The variation of DNAm in the human population is related to both genetic and environmental factor...
关键词：DNA methylation double-strand bisulfite sequencing Chinese ethnic groups Tibetan high-altitude adaptation 
Genome-wide signatures of the geographic expansion and breeding of soybean被引量：5
《Science China(Life Sciences)》2023年第2期350-365,共16页Ying-Hui Li Chao Qin Li Wang Chengzhi Jiao Huilong Hong Yu Tian Yanfei Li Guangnan Xing Jun Wang Yongzhe Gu Xingpeng Gao Delin Li Hongyu Li Zhangxiong Liu Xin Jing Beibei Feng Tao Zhao Rongxia Guan Yong Guo Jun Liu Zhe Yan Lijuan Zhang Tianli Ge Xiangkong Li Xiaobo Wang Hongmei Qiu Wanhai Zhang Xiaoyan Luan Yingpeng Han Dezhi Han Ruzhen Chang Yalong Guo Jochen C.Reif Scott A.Jackson Bin Liu Shilin Tian Li-juan Qiu 
supported by the National Key R&D Program of China(2021YFD1201601,2016YFD0100201,2020YFE0202300);the National Natural Science Foundation of China(32072091);the Platform of National Crop Germplasm Resources of China(2016-004,2017-004,2018-004,2019-04,2020-05);the Crop Germplasm Resources Protection(2016NWB036-05,2017NWB036-05,2018NWB03605,2019NWB036-05);the Agricultural Science and Technology Innovation Program(ASTIP)of Chinese Academy of Agricultural Sciences(CAASZDRW202109)。
Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We analyzed the...
关键词：SOYBEAN adaptation INTROGRESSION flowering time BREEDING 
Recent advances in RNA structurome被引量：3
《Science China(Life Sciences)》2022年第7期1285-1324,共40页Bingbing Xu Yanda Zhu Changchang Cao Hao Chen Qiongli Jin Guangnan Li Junfeng Ma Siwy Ling Yang Jieyu Zhao Jianghui Zhu Yiliang Ding Xianyang Fang Yongfeng Jin Chun Kit Kwok Aiming Ren Yue Wan Zhiye Wang Yuanchao Xue Huakun Zhang Qiangfeng Cliff Zhang Yu Zhou 
supported by the National Key Research and Development Program of China(2021YFE0114900);the National Natural Science Foundation of China(91940303,91940306,32025008,32170262,31922039,U1832215,32170229);the Natural Science Foundation of Zhejiang Province(LD21C050002);the Starry Night Science Fund at Shanghai Institute for Advanced Study of Zhejiang University(SN-ZJU-SIAS-009);the Beijing Advanced Innovation Center for Structural Biology,Shenzhen Basic Research Project(JCYJ20180507181642811);Research Grants Council of the Hong Kong SAR,China Projects(City U 11100421,City U 11101519,City U 11100218,N_City U110/17);Croucher Foundation Project(9509003);State Key Laboratory of Marine Pollution Director Discretionary Fund,City University of Hong Kong Projects(7005503,9667222,9680261);the United Kingdom Biotechnology and Biological Sciences Research Council(BBSRC:BBS/E/J/000PR9788)。
RNA structures are essential to support RNA functions and regulation in various biological processes. Recently, a range of novel technologies have been developed to decode genome-wide RNA structures and novel modes of...
关键词：RNA structurome high-throughput techniques GENOME-WIDE 3D structure RNA secondary structure SARS-CoV-2 DECODING FUNCTION 
Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry被引量：1
《Science China(Life Sciences)》2022年第4期701-717,共17页Shiyou Zhu Ying Liu Zhuo Zhou Zhiying Zhang Xia Xiao Zhiheng Liu Ang Chen Xiaojing Dong Feng Tian Shihua Chen Yiyuan Xu Chunhui Wang Qiheng Li Xuran Niu Qian Pan Shuo Du Junyu Xiao Jianwei Wang Wensheng Wei 
supported by funds from the National Key R&D Program of China (2020YFA0707800 to W.W., 2020YFA0707600 to Z.Z.);Beijing Municipal Science & Technology Commission (Z181100001318009);the National Natural Science Foundation of China (31930016);Beijing Advanced Innovation Center for Genomics at Peking University and the Peking-Tsinghua Center for Life Sciences (to W.W.);the National Natural Science Foundation of China (31870893);the National Major Science & Technology Project for Control and Prevention of Major Infectious Diseases in China (2018ZX10301401 to Z.Z.);China Postdoctoral Science Foundation (2020M670031 to Y.L.)
The outbreak of coronavirus disease 2019(COVID-19) caused by SARS-CoV-2 has created a global health crisis. SARS-CoV-2 infects varieties of tissues where the known receptor ACE2 is low or almost absent, suggesting the...
关键词：CRISPRa screen SARS-CoV-2 novel receptors 
Novel loci and potential mechanisms of major depressive disorder,bipolar disorder,and schizophrenia被引量：2
《Science China(Life Sciences)》2022年第1期167-183,共17页He Wang Zhenghui Yi Tieliu Shi 
supported by the National Key Research and Development Program of China(2015AA020108);the National Natural Science Foundation of China(31671377,81671326);Shanghai Municipal Science and Technology Major Project(2017SHZDZX01);Open Research Fund of Key Laboratory of Advanced Theory and Application in Statistics and Data Science(East China Normal University)of Ministry of Education;the Fundamental Research Funds for the Central Universities,Beihang University&Capital Medical University Advanced Innovation Center for Big Data-Based Precision Medicine Plan(BHME-201804,BHME-201904);The Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals。
Different psychiatric disorders share genetic relationships and pleiotropic loci to certain extent.We integrated and analyzed datasets related to major depressive disorder(MDD),bipolar disorder(BIP),and schizophrenia(...
关键词：psychiatric disorders multitrait analysis of genome-wide association analysis novel loci Mendelian randomization causal effects 
Genome-wide signatures of mammalian skin covering evolution被引量：1
《Science China(Life Sciences)》2021年第10期1765-1780,共16页Peng Cao Qinlong Dai Cao Deng Xiang Zhao Shishan Qin Jian Yang Ran Ju Zhiwen Wang Guoqing Lu Xiaodong Gu Zhisong Yang Lifeng Zhu 
supported by the National Natural Science Fund for Outstanding Youth Fund(31222009,31272295,31570489,81622048 and 81473377);the Project of Quality Guarantee System of Chinese Herbal Medicines(201507002);Science Foundation for Distinguished Young Scholars of Jiangsu Province(BK20140049);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
Animal body coverings provide protection and allow for adaptation to environmental pressures such as heat,ultraviolet radiation,water loss,and mechanical forces.Here,using a comparative genomics analysis of 39 mammal ...
关键词：comparative genomics skin coverings spiny mammals hairless mammals scaly mammals convergent evolution 
Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population被引量：5
《Science China(Life Sciences)》2019年第2期153-164,共12页Lulin Huang Yuhong Chen Ying Lin Pancy O.S.Tam Yilian Cheng Yi Shi Bo Gong Fang Lu Jialiang Yang Haixin Wang Yi Yin Yong Cao Dan Jiang Ling Zhong Bai Xue Jing Wang Fang Hao Dean-Yao Lee Chi-Pui Pang Xinghuai Sun Zhenglin Yang 
supported by the National Precision Medicine Project (2016YFC0905200 and 2017YFC0907302);the National Natural Science Foundation of China (81430008, 81790643, 81300802, 81670895, 81670853, 81570888 and 81870683);the Department of Science and Technology of Sichuan Province, China (2014SZ0169, 2015SZ0052, 2014FZ0124, 2015JQO057, 2017JQ0024, 2016HH0072, 2013JY0195 and 2016JQ0026);High-level Talents Program of UESTC (Y03001023601021016);the Top-Notch Young Talents Program of China (Y.S.)
Intraocular pressure(IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues fo...
关键词：INTRAOCULAR pressure GLAUCOMA GENOME-WIDE ASSOCIATION study 
Genome-wide detection of additional fetal chromosomal abnormalities by cell-free DNA testing of 15,626 consecutive pregnant women被引量：4
《Science China(Life Sciences)》2019年第2期215-224,共10页Hong Yao Ya Gao Jia Zhao Rong Zhang Huixin Xu Huamei Hu Yanmei Luo Yuying Yuan Meili Fu Hongyun Zhang Hui Jiang Wei Wang Huanming Yang Jian Wang Zhiqing Liang Fang Chen 
supported by the National Natural Science Foundation of China (81501264);Shenzhen Birth Defect Screening Project Lab (JZF No. [2016] 750);Shenzhen Municipal Government of China (JCYJ20150403101146312, JCYJ20170412153136375);Guangzhou Science and Technology Program (201604020078)
Cell-free DNA(cfDNA) testing for common fetal trisomies(T21, T18, T13) is highly effective. However, the usefulness of cfDNA testing in detecting other chromosomal abnormalities is unclear. We evaluated the performanc...
关键词：CELL-FREE DNA GENOME-WIDE CHROMOSOMAL ABNORMALITIES sensitivity SPECIFICITY PPV 
Assessing the genetic diversity of the critically endangered Chinese sturgeon Acipenser sinensis using mitochondrial markers and genome-wide single-nucleotide polymorphisms from RAD-seq被引量：3
《Science China(Life Sciences)》2018年第9期1090-1098,共9页Jian Liu Xinxin You Pao Xu Ping Zhuang Yueping Zheng Kai Zhang Min Wang Yunyun Lv Gangchun Xu Feng Zhao Jianhui Wu Houyong Fan Jianan Xu Zhiqiang Ruan Chao Bian Kai Liu Dongpo Xu Jinhui Chen Junmin Xu Qiong Shi 
supported by National Natural Science Foundation of China (31370047, U1301252);Shenzhen Scientific R & D Grant (GJHS20160331150703934);Shenzhen Dapeng Special Program for Industrial Development (KY20160102);Zhenjiang Leading Talent Program for Innovation and Entrepreneurship
As a living fossil, the endangered Chinese sturgeon(Acipenser sinensis) has been considered a national treasure in China. Here,the famous Gezhouba Dam and Three Gorges Dam on the Yangtze River were built in 1988 and 2...
关键词：Acipenser sinensis genetic diversity effective female population size mtDNA RAD-seq 
Genome-wide identification and characterization of phospholipase C gene family in cotton (Gossypium spp.)被引量：10
《Science China(Life Sciences)》2018年第1期88-99,共12页Bing Zhang Yanmei Wang Jin-Yuan Liu 
supported by the State Key Basic Research and Development Plan (2010CB126003);the National Transgenic Animals and Plants Research Project (2011ZX08005-003, 2011ZX08009-003)
Phospholipase C (PLC) are important regulatory enzymes involved in several lipid and Ca2+-dependent signaling pathways.Previous studies have elucidated the versatile roles of PLC genes in growth, development and stres...
关键词：cotton phospholipase C gene duplication fiber development stress response 
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