GENOME-WIDE

作品数：468被引量：1637H指数：17
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Investigation of the genome-wide signatures underlying the micropapillary carcinoma components in colorectal cancers
《Genes & Diseases》2025年第2期94-97,共4页Yingying Meng Zhao Zhang Tao Tang Yanhong Yu Dan Wang Wei Sun 
funded by the National Natural Science Foundation of China (No.32370820,81772976);Tianjin Science and TechnologyFunding (China) (No.21JCYBJC00300);the Key Project of Traditional Chinese Medicine of Tianjin Health Commission (No.2022006).
The invasive micropapillary carcinoma(MPC)is a rare and specialized pathologic subtype of cancer.MPCs are highly aggressive,highly metastatic,and commonly associated with poor prognosis.MPC components have been found ...
关键词：BLADDER MORPHOLOGICAL STOMACH 
Genome-wide identification and expression analysis of the GST gene family of Betula platyphylla
《Journal of Forestry Research》2025年第1期475-492,共18页Xiaoqing Hu Tong Zheng Wenjie Chen Huilei Duan Zhongjia Yuan Jiaqian An Huihui Zhang Xuemei Liu 
supported by the National Key Research and Development Program of China(No.2021YFD2200304);FundamentalResearch Funds for the Central Universities(2572022DQ08);the National Natural Science Foundation of China(No32171738).
Glutathione-S-transferase(GST,EC2.5.1.18)multifunctional protease is important for detoxification,defense against biotic and abiotic stresses,and secondary metabolic material transport for plant growth and development...
关键词：Betula platyphylla GST gene family Abiotic stress Gene expression pattern analysis Glutathione S-transferases 
The Genetic Association between CDKN1A and Heart Failure:Genome-Wide Exploration of m6A-SNPs and Mendelian Randomization被引量：1
《Biomedical and Environmental Sciences》2024年第12期1397-1408,共12页Ziyi Yang Zhennan Lin Xiaotong Ning Xingbo Mo Laiyuan Wang Xiangfeng Lu Shufeng Chen 
supported by the National Natural Science Foundation of China[82070473,82170480,82030102];Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences[2021-I2M-1-010].
Objective N6-methyladenosine(m^(6)A)is a common epigenetic modification in eukaryotes.In this study,we explore the potential impact of m^(6)A-associated single nucleotide polymorphisms(m^(6)A-SNPs)on heart failure(HF)...
关键词：Heart failure N6-methyladenosine modification Genome-wide association study Expression quantitative trait locus Mendelian randomization 
Genome-wide pan-GPCR cell libraries accelerate drug discovery
《Acta Pharmaceutica Sinica B》2024年第10期4296-4311,共16页Hanting Yang Yongfu Wang Wei Liu Taiping He Jiayu Liao Zhongzhi Qian Jinghao Zhao Zhaotong Cong Dan Sun Zhixiang Liu Can Wang Lingping Zhu Shilin Chen 
supported by introducing the talented person scientific research starts funds subsidization project of Chengdu University of Traditional Chinese Medicine(030040019,030040017,China).
G protein-coupled receptors(GPCRs)are pivotal in mediating diverse physiological and pathological processes,rendering them promising targets for drug discovery.GPCRs account for about 40%of FDA-approved drugs,represen...
关键词：G-protein coupled receptors Genome-wide pan-GPCR Transgenic cell library High-throughput screening Drug discovery 
Genome-wide DNA methylome analysis reveals a critical role of methylation-dysregulated lncRNAs in autophagy regulation in glioblastoma
《Genes & Diseases》2024年第5期51-54,共4页Hongying Zhao Ying Liu Meiting Fei Lin Bo Lixia Wang Yaopeng Shu Peiqi Ben Li Wang 
1the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province,China(No.UNPYSCT-2020174);the Excellent Youth Project of Provincial Scientific Research Institute(China)(No.CZKYF2022-1-C006);the Hei Long Jiang Postdoctoral Special Foundation(China)(No.LBH-TZ1018).
Glioblastoma(GBM)is the most common primary malignant intracranial tumor with a very poor prognosis.In this study,we systematically analyzed the DNA methylation alterations of autophagy-related lncRNAs and their assoc...
关键词：regulated alterations DRUGS 
Genome-Wide Identification and Expression Analysis of GS and GOGAT Gene Family in Pecan(Carya illinoinensis)under Different Nitrogen Forms
《Phyton-International Journal of Experimental Botany》2024年第9期2349-2365,共17页Zhenbing Qiao Mengyun Chen Wenjun Ma Juan Zhao Jiaju Zhu Kaikai Zhu Pengpeng Tan Fangren Peng 
supported by Jiangsu Provincial Forestry Bureau,Central Financial Forestry Science and Technology Promotion Demonstration Fund Project(Su[2022]TG04).
Ammonium nitrogen(NH4+-N)is one of the main forms of nitrogen absorbed and utilized by plants,and mastering the regulatory mechanism of plant ammonium assimilation is a key way to improve the efficiency of plant nitro...
关键词：PECAN NH4+-N glutamine synthetase glutamate synthase gene family 
Genome-Wide Identification of the MYB Gene Family and Screening of Potential Genes Involved in Fatty Acid Biosynthesis in Walnut
《Phyton-International Journal of Experimental Botany》2024年第9期2317-2337,共21页Dongxue Su Jiarui Zheng Yuwei Yi Shuyuan Zhang Luxin Feng Danzeng Quzhen De Qiong Weiwei Zhang Qijian Wang Feng Xu 
funded by the Shannan City Science and Technology Plan Project(2022BJKJJHXM-001);Science and Technology Project of Tibet Autonomous Region(XZ202201YD0005C).
The multifaceted roles of MYB transcriptional regulators are pivotal in orchestrating the complex processes of secondary metabolism,stress tolerance mechanisms,and life cycle progression and development.This study ext...
关键词：WALNUT JrMYB genes fatty acid synthesis gene expression bioinformatics analysis 
Genome-wide CRISPR screening identifies critical role of phosphatase and tensin homologous (PTEN) in sensitivity of acute myeloid leukemia to chemotherapy
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第8期700-710,共11页Liming LIN Jingjing TAO Ying MENG Yichao GAN Xin HE Shu LI Jiawei ZHANG Feiqiong GAO Dijia XIN Luyao WANG Yili FAN Boxiao CHEN Zhimin LU Yang XU 
supported by the Zhejiang Provincial Natural Science Foundation of China(No.LY21H080005);the National Natural Science Foundation of China(Nos.81572920 and 82100171).
Although significant progress has been made in the development of novel targeted drugs for the treatment of acute myeloid leukemia(AML)in recent years,chemotherapy still remains the mainstay of treatment and the overa...
关键词：Genome-wide clustered regularly interspaced short palindromic repeats(CRISPR)library Phosphatase and tensin homologous(PTEN) Rapamycin Acute myeloid leukemia(AML) CHEMOTHERAPY 
Exploring the molecular landscape of NNK-induced transformation:A comprehensive genome-wide CRISPR/Cas9 screening
《Genes & Diseases》2024年第4期42-44,共3页Trang Dinh Mira Rahm Zhenghe Wang Christopher McFarland Athar Khalil 
supported by grants from the National Institutes of Health(No.R01CA271540,R00CA226506 to CM,No.R01CA196643,R01CA264320,R01CA260629,P50CA150964,and P30 CA043703 to ZW).
Lung cancer is the leading cause of cancer-related deaths worldwide,with an estimated 1.8 million deaths in 2020 alone.1 While several risk factors are associated with lung cancer,smoking remains the most significant ...
关键词：CRISPR/Cas9 NNK LUNG 
Genome-wide methylation profiling identified methylated KCNA3 and OTOP2 as promising diagnostic markers for esophageal squamous cell carcinoma
《Chinese Medical Journal》2024年第14期1724-1735,共12页Yan Bian Ye Gao Chaojing Lu Bo Tian Lei Xin Han Lin Yanhui Zhang Xun Zhang Siwei Zhou Kangkang Wan Jun Zhou Zhaoshen Li Hezhong Chen Luowei Wang 
supported by the Science and Technology Commission of Shanghai Municipality(No.21Y31900100).
Background:Early detection of esophageal squamous cell carcinoma(ESCC)can considerably improve the prognosis of patients.Aberrant cell-free DNA(cfDNA)methylation signatures are a promising tool for detecting ESCC.Howe...
关键词：Esophageal squamous cell carcinoma Cell-free DNA DNA methylation landscape BIOMARKER Liquid biopsy Early detection 
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