National Natural Science Foundation of China (52125201);Beijing Natural Science Foundation (Z240025)。
In modern medical research, the analysis of biomarkers in biofluids such as blood, urine, saliva, and sweat is indispensable for revealing human physiological processes and disease states[1-4]. However, existing detec...
supported by the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(FBW,grant ZNJC202210);the CAMS Innovation Fund for Medical Sciences(FBW,grant 2022-I2M-C&T-B-118);the National Natural Science Foundation of China(XYM,grant 82303057);the Natural Science Foundation of Hubei Province of China(XYM,grant 2023 AFB521).
Background:The effective management of bladder cancer(BCa)depends on the early diagnosis and surveillance.Previous studies have explored numerous urinary molecules as potential biomarkers of BCa.However,the molecular ...
financially supported by National Natural Science Foundation of China (No.22176167);Fundamental Research Funds for the Central Universities (No.226-2023-00088);Key R&D Program of Zhejiang Province (No.2021C03125)。
RNA modifications have been involved in numerous biological processes, and aberrations of these modifications are tightly associated with various diseases including cancer. Herein, we developed graphenebased solid-pha...
support from the Collaborative Research Fund(No.C2011–21GF);from Guangdong Province Basic and Applied Basic Research Foundation(No.2021B1515120051).
Parkinson’s disease(PD)is a complex neurological disorder that typically worsens with age.A wide range of pathologies makes PD a very heterogeneous condition,and there are currently no reliable diagnostic tests for t...
Supported by the National Key Research and Development Program of China,No.2020YFC2004604 and 2020YFC2002700.
BACKGROUND A noninvasive biomarker with high diagnostic performance is urgently needed for the early diagnosis of colorectal cancer(CRC).AIM To evaluate the diagnostic value of matrix metalloproteinases(MMPs)2,7 and 9...
Key Project of Heilongjiang Province(No.ZD2018019);Research and Development Planning Project of Applied Technology of Heilongjiang Province(No.GA19C108)。
Objective:Determine the urinary biomarkers and pathogenesis of pulmonary fibrosis rats,and elaborate the intervention mechanism of DanBei YiFei formula.Methods:Bleomycin was injected into the trachea to induce pulmona...
Hepatocellular carcinoma(HCC)is the most common malignant neoplasm of the liver and one of the deadliest cancers worldwide.The identification of novel,highly specific and more sensitive biomarkers for HCC is crucial b...
Supported by National Natural Science Foundation of China,No.81972726,No.81871949 and No.81572345.
Novel non-/minimally-invasive and effective approaches are urgently needed to supplement and improve current strategies for diagnosis and management of hepatocellular carcinoma(HCC).Overwhelming evidence from publishe...
The present work was supported by the Chongqing Postdoctoral Science Foundation(Xm201313);National Natural Science Foundation of China(81471473);Research Fund for the Doctoral Program of Higher Education of China(20115503110013).
Intrahepatic cholestasis of pregnancy(ICP)is related to cholestatic disorder in pregnancy.Total urinary sulfated bile acids(SBAs)were found increased in ICP.We distinguished the metabolic profiling of urinary SBAs in ...
supported by the Science and Technology Department of Jiangxi Province(No.20141BBG70036)
Urinary brain-derived neurotrophic factor(BDNF), an ubiquitous neurotrophin, was found to rise in patients with benign prostatic hyperplasia(BPH). We hypothesized that the urinary level of BDNF could be a potentia...