LOW-MOLECULAR-WEIGHT

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Synthesis and functional evaluation of low-molecular-weight dextran sulfate as an inhibitor of TGF-β1-induced epithelial-to-mesenchymal transition in A549 cells
《Journal of Chinese Pharmaceutical Sciences》2025年第3期210-222,共13页Guohao Song Linbo Fu Yidian Mo Tongtong Geng Ximin Lv Xiangbao Meng Heng Wang Zhongtang Li Zhongjun Li 
the National Natural Science Foundation of China(Grant Nos.92478133,81930097,and 82151223);by the State Key Laboratory of Natural and Biomimetic Drugs(Grant No.K202430).
Idiopathic pulmonary fibrosis(IPF)is a progressive and fatal interstitial lung disease characterized by excessive fibrotic remodeling,for which effective therapeutic options remain severely limited.Among the pathogeni...
关键词：Idiopathic pulmonary fibrosis Epithelial to mesenchymal transition Dextran sulfate sodium Transforming growth factor-β1 A549 
A dopant-assisted iodide-adduct chemical ionization time-of-flight mass spectrometer based on VUV lamp photoionization for atmospheric low-molecular-weight organic acids analysis
《Journal of Environmental Sciences》2025年第3期500-511,共12页Yonglei Zhang Ruidong Liu Mei Li Yingzhe Guo Jichuang Kong Keyong Hou 
supported by the National Special Fund for the Development of Major Research Equipment and Instrument(No.2020YFF01014503);the Young Taishan Scholars(No.tsqn201909039);the College 20 Project fromJi Nan Science&Technology Bureau(No.2021GXRC058).
Formic and acetic acids are the most abundant gaseous organic acids and play the key role in the atmospheric chemistry.In iodine-adduct chemical ionizationmass spectrometry(CIMS),the low utilization efficiency of meth...
关键词：Formic acid Acetic acid Vacuum ultraviolet(VUV)lamp photoionization(PI) Chemical ionization(CI) Time-of-flight mass spectrometry (TOFMS) Trace gases measurement 
Fundamental Study of Rare-earth-containing Catalytic Reduction Systems for End-group Functionalization of Telechelic Low-molecular-weight Fluoropolymers
《材料导报》2025年第3期254-262,共9页LI Donghan NING Shurui YU Lu LIAO Mingyi ZHANG Mengxia YOU Shibo FANG Qinghong 
国家自然科学基金青年基金(52003165);“兴辽英才计划”青年拔尖人才(XLYC 2203101);辽宁省教育厅基金项目(LJKMZ20220769);辽宁省自然科学基金计划项目面上项目(2023-MSLH-272);沈阳中青年科技创新人才计划(RC210195);沈阳化工大学“优青”托举计划项目(2022YQ001)。
Herein the use of rare-earth compounds in catalytic reduction systems for the end-group functionalization of carboxyl-terminated low-molecularweight fluoropolymers was explored.Leveraging the high catalytic activity a...
关键词：rare-earth chloride chain-end hydroxyl group telechelic low-molecular-weight fluoropolymers sodium borohydride 
Low-molecular-weight estrogenic phytoprotein suppresses osteoporosis development through positive modulation of skeletal estrogen receptors
《Bioactive Materials》2024年第12期299-315,共17页John Akrofi Kubi Augustine Suurinobah Brah Kenneth Man Chee Cheung Andy Chun Hang Chen Yin Lau Lee Kai-Fai Lee Wei Qiao Yibin Feng Kelvin Wai Kwok Yeung 
supported by the Seed Fund for Translational and Applied Research from the University Research Committee(URC),The University of Hong Kong(HKU),Hong Kong China(Project Codes:201910160024 and 202010160009).
Age-related osteoporosis is a metabolic skeletal disorder caused by estrogen deficiency in postmenopausal women.Prolonged use of anti-osteoporotic drugs such as bisphosphonates and FDA-approved anti-resorptive selecti...
关键词：Ovariectomy(ovx) OSTEOPOROSIS Osteoblast functions Estrogen receptors(ERs) HKUOT-S2 protein 
4-Nitrocatechol as a novel matrix for low-molecular-weight compounds in situ detection and imaging in biological tissues by MALDI-MSI
《Chinese Chemical Letters》2024年第6期486-490,共5页Hualei Xu Manman Han Haiqiang Liu Liang Qin Lulu Chen Hao Hu Ran Wu Chenyu Yang Hua Guo Jinrong Li Jinxiang Fu Qichen Hao Yijun Zhou Jinchao Feng Xiaodong Wang 
supported by the National Natural Science Foundation of China(Nos.31770384 and 21605164);the Youth Academic Team Project of MUC(No.10301-02200301);the Huayi Technology Innovation Center for Research Resources(No.HTIC P01RR2017001A);the Key Laboratory Construction Funds of State Ethnic Affairs Commission of China(No.10301-02200303)。
Low-molecular-weight(LMW)compounds are ubiquitous in living organisms and play essential roles in biological processes.The direct analysis of LMW compounds in biological tissues by matrix-assisted laser desorption/ion...
关键词：MALDI-MSI 4-Nitrocatechol LMW compounds In situ detection Tissue imaging 
Measurement of very low-molecular weight metabolites by traveling wave ion mobility and its use in human urine samples
《Journal of Pharmaceutical Analysis》2024年第5期733-743,共11页Alongkorn Kurilung Suphitcha Limjiasahapong Khwanta Kaewnarin Pattipong Wisanpitayakorn Narumol Jariyasopit Kwanjeera Wanichthanarak Sitanan Sartyoungkul Stephen Choong Chee Wong Nuankanya Sathirapongsasuti Chagriya Kitiyakara Yongyut Sirivatanauksorn Sakda Khoomrung 
supported by the Postdoctoral Fellowship Program(Grant No.:(IO)R016320001)by Mahidol University,Thailand.;supported by Mahidol University,Thailand(to Associate Professor Sakda Khoomrung);funding support from the National Science,Research and Innovation Fund(NSRF)via the Program Management Unit for Human Resources&Institutional Development,Research and Innovation,Thailand(Grant No.:B36G660007).
The collision cross-sections(CCS)measurement using ion mobility spectrometry(IMS)in combination with mass spectrometry(MS)offers a great opportunity to increase confidence in metabolite identification.However,owing to...
关键词：Very low-molecular-weight metabolites Traveling wave ion mobility Collision cross-section Human urine 
Low-molecular-weight fucoidan inhibits the proliferation of melanoma via Bcl-2 phosphorylation and PTEN/AKT pathway
《Oncology Research》2024年第2期273-282,共10页MINJI PARK CHULHWAN BANG WON-SOO YUN YUN-MI JEONG 
supported by the Priority Research Centers Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,Science and Technology(Grant 2017R1A6A03015562 and RS-2023-00237386).
Fucoidan,a sulfate polysaccharide obtained from brown seaweed,has various bioactive properties,including anti-inflammatory,anti-cancer,anti-viral,anti-oxidant,anti-coagulant,anti-thrombotic,anti-angiogenic,and anti-He...
关键词：Low-molecular-weight fucoidan MELANOMA Patient-derived melanoma explants in a 3D-printed collagen scaffold Anti-melanoma effect PTEN-AKT-Bcl-2 network 
Adsorption of trichlorphon on phyllosilicate minerals:Effect of low-molecular-weight organic acids
《Pedosphere》2024年第1期78-87,共10页Hongfeng CHEN Zhouyang HE Mingxia HOU Cilai TANG Yonghong WU 
financially supported by the National Natural Science Foundation of China(Nos.41825021,42007020,and 21876097);the National Natural Science Foundation Project of International Cooperation and Exchange,China(No.41961144010)。
The use of trichlorphon in large quantities causes a large number of organic pollutants to enter water, sediments, and soils. Phyllosilicate minerals are considered effective adsorbents for organic pollutants. However...
关键词：adsorption behavior citric acid hydrophobic effect organic pesticide organic pollutant ORGANOCHLORINE oxalic acid 
Low-molecular-weight supramolecular adhesive with resistance to low temperatures
《Chinese Chemical Letters》2023年第5期232-236,共5页Shuanggen Wu Wenbo Wang Changyong Cai Fenfang Li Shengyi Dong 
the Outstanding Youth Scientist Foundation of Hunan Province(No.2021JJ10010);the Huxiang Young Talent Program from Hunan Province(No.2018RS3036);the Fundamental Research Funds for the Central Universities from Hunan University;supported by the Hunan Provincial Innovation Foundation for Postgraduate(No.CX20200446)。
The design of adhesive materials with strong adhesion capacity at low temperatures is a great challenge.Herein,we report a low-molecular-weight supramolecular adhesive that exhibits good adhesion performance to variou...
关键词：Supramolecular adhesive Low temperature resistance Underwater adhesion Low-molecular-weight monomer Supramolecular adhesion 
Designing a New Lattice Model to Simulate Low-molecular-weight Block Copolymers for Nanolithographic Applications
《Chinese Journal of Polymer Science》2022年第4期413-420,共8页Jia-Ping Wu Bao-Hui Li Qiang Wang 
the National Natural Science Foundation of China(No.21829301);the 111 Project(No.B16027).
A new lattice model is designed to be suitable for simulating low-molecular-weight block copolymer(BCP)melts currently used in experiments to achieve sub-10 nm domain sizes(i.e.,having an invariant degree of polymeriz...
关键词：Lattice model Block copolymers FLUCTUATIONS 
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