In this editorial,we comment on the article by Zhao et al which highlighted how patients having nonalcoholic fatty liver disease(NAFLD)were more susceptible to drug-induced lung injury(DILI).This article looked at the...
Rationale:Opioids,the class of drugs,frequently used for pain relief in acute pancreatitis are known to act as a dual-edged sword.They are capable of causing acute pancreatitis though very rare.Patient’s Concern:A 45...
In a recent publication in Cell,a multidisciplinary academic drug discovery team,with its spin-off HepaRegeniX,published a first-in-class small molecule MKK4 inhibitor(HRX215)with remarkable efficacy in multiple precl...
Alectinib is a selective Anaplastic Lymphoma Kinase (ALK) tyrosine kinase inhibitor used as standard therapy for ALK-rearranged lung adenocarcinoma. Hemolytic anemia is considered a rare but significant adverse event ...
Introduction:Toxic epidermal necrolysis(TEN)is a medical emergency that most commonly occurs as an adverse effect of certain drugs.Here,we describe a case of a 41-year-old man with no comorbid illness who developed TE...
Several features of drug-induced mucosal alterations have been observed in the upper gastrointestinal tract,i.e.,the esophagus,stomach,and duodenum.These include pill-induced esophagitis,desquamative esophagitis,worse...
Scientific Research Project of Heilongjiang Provincial Education Department(No.12531608)。
Objective:To study the effect of Yigan capsule on the expression of high mobility group protein B1(HMGB1),nuclear factor-B(NF-κB)and receptor for advanced glycation end products(RAGE)in anti-tuberculosis drug-induced...
supported by the CAMS Innovation Fund for Medical Sciences(CIFMS)(2021-1-I2M-006,2023-I2M-1-003,2022-I2M-2-001,2021-1-I2M-019);the National Natural Science Foundation of China(82070287,82088101 and 82025004);the National Key Research and Development Program of China(2022YFA1104500)。
Mitochondrial toxicity induced by therapeutic drugs is a major contributor for cardiotoxicity,posing a serious threat to pharmaceutical industries and patients’lives.However,mitochondrial toxicity testing is not inco...
BACKGROUND This case report addresses the dearth of effective therapeutic interventions for central nervous system metastases in patients with HER2-negative breast cancer.It presents a unique case of a woman with estr...
Dr.Vishwanath Karad MIT-World Peace University,Pune,411038 India and Dr.D.Y.Patil Dental College,and Hospital,Pimpri,Pune-411018 India.
Orthodontic procedures can be inconvenient in nature.To overcome this problem,accelerated orthodontics play a very important role to reduce existing trouble and discomfort.The most common inconvenience caused during o...