In biological development, morphogens are locally produced and spread to other regions in organs, forming gradients that control the inter-related pattern and growth of developing organs. Mechanisms of morphogen trans...
Supported by Bundesministerium für Forschung und Technologie(BMBF)in the framework of the Systems Biology initiative"Virtual Liver Network",No.0315735
Liver zonation, the spatial separation of the immense spectrum of different metabolic pathways along the liver sinusoids, is fundamental for proper functioning of this organ. Recent progress in elucidating localizatio...
During embryo development in many metazoan animals, the first differentiated cell type to form is anepithelial cell. This epithelial layer is modified by developmental cues of body axes formation to give rise to vario...
We thank Dr Jin Jiang (University of Texas Southwestern Medical Center at Dallas, USA), Dr Robert Holmgren (Northwestern University, USA), the ARIAD Pharmaceuticals and Developmental Studies Hybridoma Bank at the university of Iowa for reagents. We thank Dr Xiaochen Wang (National Institute of Biological Sciences, China), Dr Min Wu (Wuhan University, China) and Dr Zhaocai Zhou (Institute of Biochemistry and Cell Biology, CAS, China) for critical comments on the manuscript. This work was supported by grants from the National Natural Science Foundation of China (30623003, 30971647 and 30971646), the National Key Scientific Program of China (2011 CB943902 and 2010CB912100), Shanghai Pujiang Program (09PJ1410900) and also from the "Strategic Priority Research Program" of the Chinese Academy of Sciences (XDA01010405 and XDA01010406). Y Z and L Z are the scholars of the Hundred Talents Program of the Chinese Academy of Sciences.
The Hedgehog (Hh) family of secreted proteins is essential for development in both vertebrates and invertebrates. As one of main morphogens during metazoan development, the graded Hh signal is transduced across the ...