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  • 期刊=Signal Transduction and Targeted Therapyx
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Gut microbial carcinogen metabolism:another avenue to cancer
《Signal Transduction and Targeted Therapy》2024年第11期4783-4784,共2页Florian R.Greten Melek C.Arkan 
Work in the lab of FRG and MCA is funded by institutional funds from the Georg-Speyer-Haus,the LOEWE Center Frankfurt Cancer Institute(FCI)funded by the Hessen State Ministry for Higher Education,Research and the Arts LOEWE,grants to FRG from the Deutsche Forschungsgemeinschaft(FOR2438:Gr1916/11-1,SFB1292-Project ID:318346496-TP16,SFB1479-Project ID:441891347-P02,GRK2336)the German Federal Ministry of Education;Research(BMBF,01KD2206Q/SATURN3);the European Research Council(Advanced Grant PLASTICAN-101021078).
A recent study published in Nature by Roje,Zhang and colleagues highlights the emergent role gut microbiota play in processing environmental carcinogens and raises its potential as a target for reducing cancer risk in...
关键词：METABOLISM CANCER pathogenesis 
Harnessing naturally occurring mutations for T-cell therapy:a potential new avenue to enhance treatment efficacy
《Signal Transduction and Targeted Therapy》2024年第5期1799-1801,共3页Michael Hiltensperger Jürgen Ruland Kilian Schober 
K.S.is supported by grants from the German Federal Ministry of Education and Research(BMBF,project-IDs 01KI2013 and 031L0290B);the Else Kröner-Fresenius-Stiftung(project-ID 2020_EKEA.127);the German Research Foundation(DFG)through the research training group RTG 2504(project-ID 401821119);the Interdisciplinary Center for Clinical Research of the University Hospital of Erlangen(project-ID A98);the European Union(Yellow4FLAVI consortium,project-ID 101137459);J.R.is supported by grants from the German Research Foundation(DFG)(project-ID 210592381-SFB 1054,project-ID 395357507-SFB 1371,project-ID 369799452-TRR 237,project-ID 452881907-TRR 338,project-ID 435874434-RTG 2668,RU 695/12-1);The Leukemia&Lymphoma Society,and the European Research Council(ERC)under the European Union’s Horizon 2020 research and innovation programme(grant agreement No 834154).
In a recent study published in Nature,Garcia et al.use a sophisticated approach to identify fitness-enhancing mutations for T cells that was inspired by cancer evolution.1 The identified CARD11-PIK3R3 gene fusion enha...
关键词：cancer POTENTIAL 
IL4I1-driven AHR signature: a new avenue for cancer therapy
《Signal Transduction and Targeted Therapy》2021年第4期1086-1087,共2页Zuli Wang Tiansheng Li Chao Mao Wenliang Liu Yongguang Tao 
This work was supported by the National Natural Science Foundation of China[81672787,82072594,Y.T.,81972638,W.L.,82002916,C.M.];China Postdoctoral Science Foundation[2019M652804,CM.];Natural Science Foundation of Hunan Province[2020JJ5790,C.M.];Hunan Provincial Key Area R&D Programs[2019SK2253,Y.T.];Postdoctoral Foundation of Central South University[220372,C.M.];Shenzhen Science and Technology Program[KQTD20170810160226082];Shenzhen Municipal Government of China[JCYJ20180507184647104].
Aryl hydrocarbon receptor(AHR)was considered to be an important pan-tumor therapeutic target,but small molecule inhibitors targeting AHR target gene ID01 have failed in clinical trials.The recent paper published in Ce...
关键词：SIGNATURE explained identif 
Correction: Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy被引量：1
《Signal Transduction and Targeted Therapy》2021年第3期1069-1069,共1页Ajaz A.Bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael El-Rifai Michael P.Frenneaux Surinder K.Batra Mohammad Haris Muzafar A.Macha 
Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-020-00419-w,published online 12 January 2021 After online publication of the article1,the authors noticed an error in affiliation o...
关键词：Cancer SQUAMOUS TARGETED 
Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy被引量：1
《Signal Transduction and Targeted Therapy》2021年第2期324-338,共15页Ajaz A.Bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael EI-Rifai Michael P.Frenneaux Surinder K.Batra Mohammad Haris Muzafar A.Macha 
This study was supported by Ramalingaswami Fellowship(Grant number:D.O.NO.BT/HRD/35/02/2006)from the Department of Biotechnology,Government of India,New Delhi to Muzafar A.Macha;Mohammad Haris is funded by a grant(5071012001)from Sidra Medicine Doha,Qatar;Ajaz A.Bhat is supported by Sidra Medicine internal grant(5011041002).We thank Dr.Vineeta Tanwar(Ohio State University,Columbus,Ohio,USA)for her professional assistance in editing the paper.
Head and neck squamous cell carcinoma(HNSCC)is a very aggressive disease with a poor prognosis for advanced-stage tumors.Recent clinical,genomic,and cellular studies have revealed the highly heterogeneous and immunosu...
关键词：TARGETED SQUAMOUS thereby 
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