NUCLEOPORIN

作品数：11被引量：27H指数：3
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相关机构：中国科学院大学更多>>
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Post-translational O-GlcNAcylation is essential for nuclear pore integrity and maintenance of the pore selectivity filter被引量：1
《Journal of Molecular Cell Biology》2016年第1期2-16,共15页Yanping Zhu Ta-Wei Liu Zarina Madden Scott A.Yuzwa Kelsey Murray Samy Cecioni Natasha Zachara David J.Vocadlo 
supported by a Discovery Grant(grant no.RGPIN/298406-2010)fromthe Natural Sciences and Engineering Research(NSERC),and the Canadian Institutes of Health Research(CIHR)(grant no.MOP-123341).Y.Z.thanks the CIHR for support through a postdoctoral fellowship.D.J.V.acknowledges the kind support of the Canada Research Chairs Program for a Tier I Canada Research Chair in Chemical Glycobiology and NSERC for support as an E.W.R.Steacie Memorial Fellow.N.Z.acknowledges the support from the National Heart Lung and Blood Institute(P01HL107153).
O-glycosylation of the nuclear pore complex(NPC)by O-linked N-acetylglucosamine(O-GlcNAc)is conserved within metazoans.Many nucleoporins(Nups)comprising the NPC are constitutively O-GlcNAcylated,but the functional rol...
关键词：post-translational modification O-GLCNACYLATION nuclear pore complex protein stability UBIQUITINATION NUCLEOPORIN GLYCOSYLATION 
Nucleoporin 35 regulates cardiomyocyte pH homeostasis by controlling Na^(+)-H^(+)exchanger-1 expression
《Journal of Molecular Cell Biology》2015年第5期476-485,共10页Liang Xu Lei Pan Jun Li Bijun Huang Jing Feng Changming Li ShiyiWang Erlinda The Yuan Liu Tianyou Yuan Lixiao Zhen Dandan Liang Yi Liu Li Li Yingyu Cui Xiaoyan Jiang Luying Peng Yi-Han Chen 
This work was supported by grants from the National Key Basic Research Program of China(2013CB531100 to Y.-H.C.);the National Natural Science Foundation of China for National Innovative Research Groups(81221001 to Y.-H.C.);the Major International Joint Research Program of China(81120108004 to Y.-H.C.);the Youth Program(81100124 to L.X.);the General Program(81170224 and 81270313 to J.L.and 31271214 to Y.-H.C.)of the National Natural Science Foundation of China.
The mammalian nuclear pore complex is comprised of∼30 different nucleoporins(Nups).It governs the nuclear import of gene expression modulators and the export of mRNAs.In cardiomyocytes,Na1-H1 exchanger-1(NHE1)is an i...
关键词：CARDIOMYOCYTE intracellular pH Na^(+)-H^(+)exchanger nuclear pore complex nucleo-cytoplasmic transport 
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