supported by the National Science Fund for Distinguished Young Scholars (22225701);National Natural Science Foundation of China (92253302, 22077080 and 31970879);Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University (21TQ1400210);National Key R&D Program of China (2021YFC2301303 and 2022YFC2303700);Special Projects of the Central Government in Guidance of Local Science and Technology Development (2021Szvup077)
Vaccines have been the primary remedy in the global fight against coronavirus disease 2019(COVID-19).The receptor-binding domain(RBD)of the spike protein,a critical viral immunogen,is affected by the heterogeneity of ...
Immune-based therapies have experienced a pronounced breakthrough in the past decades as they acquired multiple US Food and Drug Administration(FDA)approvals for various indications.To date,six chimeric antigen recept...
The effector functions elicited by the fragment crystallizable (Fc) region of immunoglobulin G (IgG) antibodies are subject to variation by the presence of terminal sialic acid (Sia) residues at asparagine-297 (Asn-29...
supported by National Science and Technology Task Force Project (2006BAD06A13-2);National Basic Research Program of China (973 Program) (2007CB310505);Institution Technique R&D Grand (2008EG150300);National Natural ScienceFoundation of China (Grants 30571672, 30500018, 30771914, and 30800975)
Objective To establish a stable PrP^Sc panel from brain tissues of experimental hamsters infected with scrapie agent 263K for evaluating diagnostic techniques of human and animals' prion diseases. Methods Thirty brai...