LIDAMYCIN

作品数：19被引量：65H指数：6
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相关领域：医药卫生更多>>
相关作者：刘芳陈淑珍商悦甄永苏吴淑英更多>>
相关机构：中国医学科学院北京协和医学院中国医学科学院中国协和医科大学清华大学更多>>
相关期刊：《Science Bulletin》《中国抗生素杂志》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>
相关基金：国家高技术研究发展计划国家自然科学基金国家重点基础研究发展计划更多>>
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Chloroquine potentiates the anti-cancer effect of lidamycin on non-small cell lung cancer cells in vitro被引量：4
《Acta Pharmacologica Sinica》2014年第5期645-652,共8页Fang LIU Yue SHANG Shu-zhen CHEN 
This investigation received support from the National Natural Science foundation of China （No 81072664 and 81373437） and the National Science and Technology Major Project of China （Grant No 2012ZX09301002-001-022-01）.Shu-zhen CHEN designed the study and edited the paper; Fang LIU performed the research, analyzed the data and wrote the paper; and Yue SHANG performed the mouse experiments.
Aim： To assess the synergistic actions of lidamycin （LDM） and chloroquine （CQ）, a lysosomal enzyme inhibitor, in human non-small cell lung cancer （NSCLC） cells, and to elucidate the potential mechanisms. Method...
关键词：lung cancer anticancer drug LIDAMYCIN CHLOROQUINE drug interaction synergism APOPTOSIS AUTOPHAGY 
Optimization of the Assembly Efficiency for Lidamycin Chromophore Bound to its Apoprotein:A Case Study using Orthogonal Array被引量：9
《Biomedical and Environmental Sciences》2011年第6期602-607,共6页ZHONG Gen Shen GUO Xiao Fang ZHANG Sheng Hua ZHEN Yong Su 
supported by grants from "Significant new drug development" Science and Technology Major Projects of China (2009ZX09301-003; 2009ZX09401-005; 2010ZX09401-407)
Objective Lidamycin （LDM） can be dissociated to an apoprotein （LDP） and an active enediyne chromophore （AE）. The detached AE can reassemble with its LDP-containing fusion protein to endow the latter with potent ...
关键词：LIDAMYCIN CHROMOPHORE HPLC Orthogonal array Assembly rate Lidamycin CHROMOPHORE HPLC Orthogonal array Assembly rate 
Antitumor effects of an engineered and energized fusion protein consisting of an anti-CD20 scFv fragment and lidamycin被引量：6
《Science China(Life Sciences)》2011年第3期255-262,共8页FANG Hong MIAO QingFang ZHANG ShengHua CHENG Xin XIONG DongSheng ZHEN YongSu 
supported by the National High Technology Research and Development Program of China(Grant No. 2006AA02A255);the National Natural Science Foundation of China(Grant No. 30701029);the National Science and Technology Major Projects(Grant Nos.2009ZX09103-720 and 2010ZX09401-407)
Antibody-based fusion proteins are the next generation of antibody therapies for cancer and other diseases.CD20 antigen,which is overexpressed on cell membranes in nearly 95% of cases of B-cell Non-Hodgkin's Lymphoma,...
关键词：LYMPHOMA CD20 LIDAMYCIN SCFV energized fusion protein 
Lidamycin Induces Apoptosis of B-Cell Lymphoma Cells and Inhibits Xenograft Growth in Nude Mice
《Clinical oncology and cancer researeh》2009年第3期203-207,共5页Hong Fang Shenghua Zhang Qingfang Miao Dongsheng Xiong Yongsu Zhen 
supported by a grant from the National High Technology Research and Development Program of China(No.2006AA02A255).
OBJECTIVE To study the cytotoxicity of Lidamycin （LDM） and its induction of apoptosis in Raji and Daudi cells of B-cell lymphoma, and the inhibition of growth of the lymphoma Raji xenograft in nude mice. METHODS MTT...
关键词：lidamycin （LDM） LYMPHOMA B-CELL apoptosis. 
Lidamycin shows highly potent cytotoxic to myeloma cells and inhibits tumor growth in mice被引量：8
《Acta Pharmacologica Sinica》2009年第7期1025-1032,共8页Yong-zhan ZHEN Ya-jun LIN Yi LI Yong-su ZHEN 
Aim： To investigate the effects of lidamycin （LDM） on a mouse myeloma cell line （SP2/0） and human multiple myeloma cell lines （U266 and SKO-007）, and provide the basis for the use of LDM in cancer therapy. Meth...
关键词：LIDAMYCIN mouse myeloma multiple myeloma JNK SP2/0 cells 
Effect of Lidamycin on Telomerase Activity in Human Hepatoma BEL-7402 Cells被引量：3
《Biomedical and Environmental Sciences》2007年第3期189-197,共9页RUI-JUAN GAO YUE-XIN LIANG DIAN-DONG LI HONG-YIN ZHANG YONG-SU ZHEN 
This study was supported by the National High Technology Research and Development Program of China (863 Programm Grant No.2006AA02A255);the National Natural Science Foundation of China (Grant No.30472042; 30300424).
Objective To investigate the effect of lidamycin （LDM） on telomerase activity in human hepatoma BEL-7402 cells under the condition of LDM inducing mitotic cell death and senescence. Methods Chromatin condensation wa...
关键词：LDM Mitotic cell death Cellular senescence Telomerase activity 
Lidamycin inhibits proliferation and induces apoptosis in endot helial cells被引量：5
《中国抗生素杂志》2003年第10期605-612,共8页王心华 吴淑英 甄永苏 
This study was supported by a grant from China State Key Basic Research Project(G1998051212);a grant from National Foundation for Cancer Research,USA.
目的　研究力达霉素 (lidamycin,L DM)对内皮细胞的增殖抑制作用和诱导细胞凋亡作用。方法　用 MTT测定法和[3H]胸苷掺入测定法观察 L DM对内皮细胞的增殖抑制 ;用流式细胞分析、形态观察、蛋白质印迹分析等方法研究 L DM诱导内皮细胞...
关键词：力达霉素 血管生成 内皮细胞 细胞增殖 细胞凋亡 
Cloning,expression and characterization of gene sgcD involved in the biosynthesis of novel antitumor lidamycin
《Science China(Life Sciences)》2003年第3期310-319,共10页李敏 刘文 李元 
supported by the National Natural Science Foundation of China(Grant No.39870029).
Lidamycin with high antitumor activity is a novel enediyne antitumor antibiotic produced by Streptomyces globisporus C1027. The 75 kb biosynthesis gene cluster of lidamycin containing 33 open reading frames has been c...
关键词：Streptomyces  lidamycin  biosynthesis  gene disruption  aminomutase. 
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