ISOSTEVIOL

作品数：8被引量：8H指数：2
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相关领域：理学医药卫生更多>>
相关作者：张雁冰邹大鹏陶京朝田国强朱玉更多>>
相关机构：郑州大学广东工业大学浙江工业大学河南牧业经济学院更多>>
相关期刊：《Chinese Journal of Chemistry》《Chemical Research in Chinese Universities》《有机化学》《合成化学》更多>>
相关基金：国家自然科学基金河南省自然科学基金更多>>
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Simultaneous improvement to solubility and bioavailability of active natural compound isosteviol using cyclodextrin metal-organic frameworks被引量：3
《Acta Pharmaceutica Sinica B》2021年第9期2914-2923,共10页Xiaojin Chen Tao Guo Kaikai Zhang Jiacai Chen Caifen Wang Xiaohong Ren Qin Wang Yingchao Yang Chongjing Liu Wen Tan Shuangying Gui Li Wu Jiwen Zhang 
financial support from the National Science Foundation for Young Scientists of China(No.81803441);the National Science and Technology Major Projects for the Major New Drugs Innovation and Development(No.2018ZX09721002-009,China);the National Natural Science Foundation of China(No.81873019);the University Synergy Innovation Program of Anhui Province(GXXT-2020-025)
Cyclodextrin metal-organic framework(CD-MOF)as a highly porous supramolecular carrier could be one of the solutions to the insolubility of isosteviol(STV).The solubility of STV was lower than20.00 ng/mL at pH 1.0 and ...
关键词：ISOSTEVIOL Cyclodextrin metalorganic framework Drug loading NANOCLUSTERS SOLUBILITY BIOAVAILABILITY SUPRAMOLECULE Molecular simulation 
基于Isosteviol的双功能手性硫脲催化剂的设计合成及应用
《郑州牧业工程高等专科学校学报》2015年第2期28-32,共5页马志伟 舒友琴 
手性有机小分子催化是继有机金属催化和酶催化之后的又一种重要的不对称催化方法,近年来在新催化剂的设计和新催化概念的提出方面取得了很大的进展,并逐渐发展成为当代有机合成中最具活力的领域之一。基于"单分子、双功能活化"这一有机...
关键词：有机不对称催化 双功能手性催化剂 MICHAEL加成反应 异斯特维醇 硫脲 
Isosteviol-amino Acid Conjugates as Highly Efficient Organocatalysts for the Asymmetric One-pot Three-component Mannich Reactions被引量：4
《Chinese Journal of Chemistry》2011年第7期1511-1517,共7页安雅洁 秦倩 王川川 陶京朝 
Project supported by the National Natural Science Foundation Of China （No. 20772113）.
Isosteviol-amino acid conjugates were synthesized and used as chiral catalysts for the asymmetric three-component Mannich reaction with hydroxyacetone as donor molecule. Good yields （up to 98%） and excellent stereos...
关键词：isosteviol-amino acid conjugates asymmetric catalysis mannich reaction HYDROXYACETONE enantiose- lectivity 
Synthesis of 17-OH-Isosteviol
《Chemical Research in Chinese Universities》2009年第1期116-117,共2页LI He-ping DONG Cheng-min HOU Yi-min LIU Hong-min 
Supported by the National Natural Science Foundation of China(No.20572103).
Stevioside（1）, an ent-kaurene glycoside commercially extracted from Stevia rebaudiana Bertoni is used as a non-caloric sweetener for food in many countries. The increasing demand for low calory and natural food cont...
关键词：Mucor hiemalis BIOTRANSFORMATION ISOSTEVIOL 
Synthesis and Bioactivity of Isosteviol Derivatives: A Facile Method for Preparation of Ent-16α-hydroxy-15β-hydroxymethylbeyeran-19-oic Acid被引量：1
《Chinese Chemical Letters》2005年第11期1441-1444,共4页Jing Chao TAO Guo Qiang TIAN Yan Bing ZHANG Yu Qin FU Gui Fu DAI Ya WU 
the National Natural Science Foundation of China(20372059);Natural Science Foundation of Henan Province for the financial support(0311020500).
In this paper, two new compounds, ent-16α-hydroxy-15β-hydroxymethylbeyeran-19-oic acid 4 and its ethyl ester 5 were synthesized in good yield with a facile method that has never been reported. The mechanism of this ...
关键词：ISOSTEVIOL 1 3-diol hydroxylation. 
Synthesis and Crystal Structure of Isosteviol Derivatives
《合成化学》2004年第z1期76-76,共1页Tao Jing-Chao Tian Guo-Qiang Zhang Yan-Bing Wu Ya Liu Hong-Min 
Supported by the National Natural Science Foundation of China (No. 20372059).
关键词：Synthesis and Crystal Structure of Isosteviol Derivatives 
15-β-羟甲基-16-α-羟基ISOSteViol衍生物的合成与结构研究
《有机化学》2003年第z1期367-,共1页张雁冰 田国强 朱玉 邹大鹏 陶京朝 
国家自然科学基金(No.20272054)和河南省自然科学基金资助项目.
　　异斯特维醇(Isosteviol)是一种贝叶烷二萜类化合物,具有广泛的生理活性,可由甜叶菊苷(Stevioside)经酸性水解得到.从异斯特维醇出发,利用其合适的二萜骨架,可以衍生出各种具有生物活性和光学活性的多羟基衍生物和具有抗肿瘤活性的...
The Crystal Structure of Isosteviol
《Chemical Research in Chinese Universities》1993年第3期201-207,共7页XUE Jie-you , TANG Shi-xiong, CAO Yu-rong and WANG Xiao-lan (Department of Chemistry, Nankai University, Tianjin, 300071)WANG Ru-ji, WANG Hong-gen and LU Xiang-jun (Dental Laboratory, Nankai University, Tianjin, 300071) 
Supported by the National Natural Science Foundation of China
The title compound was prepared and its crystal structure was determined using X-ray crystallographic method. The crystal is orthorhombic, space group is P212121 with a= 1. 1114(2) nm, b=1.7677(3) nm, c=1.8312(3) nm; ...
关键词：ISOSTEVIOL Crystal structure SYNTHESIS 
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