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TNFα-reliant FSP1 up-regulation promotes intervertebral disc degeneration via caspase 3-dependent apoptosis
《Genes & Diseases》2025年第1期327-340,共14页Cheng Qiu Lin Cheng Derun Di Ziqian Xiang Congyu Wang Jinghang Li Yinuo Xiong Manyu Li Jingwei Liu Jian Zhou Tianyi Liu Xinyu Wang Dan Luo Xiaoxiong Wang Shangye Li Hui Wang Xia Wang Yunpeng Zhao Xinyu Liu Lianlei Wang 
supported in part by the National Natural Science Foundation of China(No.81874022 and 82172483 to Xinyu Liu,No.82102522 to Lianlei Wang);Key R&D Project of Shandong Province(China)(No.2022CXGC010503 to Xinyu Liu);Shandong Natural Science Foundation(No.ZR202102210113 to Lianlei Wang);Shandong Province Taishan Scholar Project(No.tsqn 202211317 to Lianlei Wang);National High Level Hospital Clinical Research Funding(No.2022-PUMCH-D-004).
Intervertebral disc degeneration(IDD)is a common chronic inflammatory degenerative disease that causes lower back pain.However,the underlying mechanisms of IDD remain unclear.Ferroptosis suppressor protein 1(FSP1)is a...
关键词：Caspase 3 FSP1 iFSP1 Intervertebraldisc degeneration NF-ΚB TNFΑ 
Loss of GATA6-mediated up-regulation of UTX promotes pancreatic tumorigenesis and progression被引量：1
《Genes & Diseases》2024年第2期921-934,共14页Hui-Qing Zhang Fanyang Kong Xiangyu Kong Tingting Jiang Muyuan Ma Shaojiang Zheng Junli Guo Keping Xie 
supported by the Jiangxi Science Fund for Distinguished Young Scholars(China)(No.20212ACB216012);the Funding Program for Academic and Technical Leaders of Main Subjects in Jiangxi Province,China(No.20213BCJ22009 to H.Q.Zhang);the National Natural Science Foundation of China(No.81460372 to H.Q.Zhang,No.81960528 to S.Zheng);the Hainan Province Science and Technology special fund(China)(ZDYF2020132 to S.Zheng);the Innovation Platform for Academicians of Hainan Province(China)(YSPTZX202208 to S.Zheng);Hainan Province Clinical Medical Center(QWYH2021276);the Cardiovascular Disease Research Science Innovation Group of Hainan Medical University(China).
Ubiquitously transcribed tetratricopeptide repeat on chromosome X(UTX),also known as lysine(K)-specific demethylase 6A(KDM6A),functions as a tumor suppressor gene or oncogene depending on the tumor type and context.Ho...
关键词：Growth INVASION METASTASIS Pancreatic cancer UTX 
Loss of ARID1A Promotes Hepatocellular Carcinoma Progression via Up-regulation of MYC Transcription被引量：3
《Journal of Clinical and Translational Hepatology》2021年第4期528-536,共9页Yao Xiao Guodong Liu Xiwu Ouyang Denggao Zai Jixiang Zhou Xiaoli Li Qi Zhang Jie Zhao 
This work was supported by Zhejiang Provincial Natural Science Foundation(LQ18H160010,LQ20C010005);National Natural Science Foundation of China(82003062,81903004).
Background and Aims:AT-rich interactive domain-containing protein 1A(ARID1A)is frequently mutated or deficient in hepatocellular carcinoma(HCC).However,the role of ARID1A in HCC remains unclear.Therefore,the biologica...
关键词：ARID1A Hepatocellular carcinoma MYC 
Piperlongumine Inhibits Zika Virus Replication In vitro and Promotes Up-Regulation of HO-1 Expression, Suggesting An Implication of Oxidative Stress被引量：5
《Virologica Sinica》2021年第3期510-520,共11页Weizhi Lu Linjuan Shi Jing Gao Huimin Zhu Ying Hua Jintai Cai Xianbo Wu Chengsong Wan Wei Zhao Bao Zhang 
supported by the National Natural Science Foundation (Nos. 31670168, 31470271 and 81730110);National Key R&D Program of China (Grant No. 2018YFC1602206);Guangdong Provincial Science and Technology (No. 2018B020207006)。
Owing to the widespread distribution of mosquitoes capable of transmitting Zika virus, lack of clinical vaccines and treatments, and poor immunity of populations to new infectious diseases, Zika virus has become a glo...
关键词：Piperlongumine Heme oxygenase-1(HO-1) Reactive oxygen species Zika virus(ZIKV) Human brain microvascular endothelial cells 
IL-2Rα up-regulation is mediated by latent membrane protein 1 and promotes lymphomagenesis and chemotherapy resistance in natural killer/T-cell lymphoma被引量：7
《Cancer Communications》2018年第1期667-676,共10页Liang Wang Xi-wen Bi Yu-jia Zhu Ying-zhi He Qiu-yu Lai Zhong-jun Xia Qing-qing Cai 
the National Natural Science Foundation of China(81400159,81873450,81700196,81672686);Pearl River Nova Program of Guangzhou(201710010161);Sister Institution Net-work Fund of the MD Anderson Cancer Center(to Qingqing Cai);the Fundamental Research Funds for the Central Universities(17ykpy77).
Background:Natural killer/T-cell lymphoma(NKTCL)is a highly aggressive non-Hodgkin lymphoma often resistant to chemotherapy.Serum level of soluble IL-2 receptorα(IL-2Rα)is elevated in NKTCL patients and correlates s...
关键词：Natural killer/T-cell lymphoma Latent membrane protein 1 Epstein-Barr virus Interleukin-2 receptor alpha 
HOXC10 up-regulation promotes gastric cancer cell proliferation and metastasis through MAPK pathway被引量：12
《Chinese Journal of Cancer Research》2017年第6期572-580,共9页Chen Guo Jianing Hou Sheng Ao Xingming Deng Guoqing Lyu 
supported by the grants from‘San Ming’Project of Shenzhen city,China;Municipal Health planning Commission Fund of Shenzhen city,China(No.201601004 and No.201704260051)
Objective： As an important regulator of embryonic morphogenesis, homeodomain-containing gene 10 （HOXC10） has been found to promote progression of human cancers and its expression indicates poor survival outcome. Ho...
关键词：HOXCIO PROLIFERATION METASTASIS gastric cancer 
KDM4B promotes epithelial-mesenchymal transition through up-regulation of ZEB1 in pancreatic cancer被引量：8
《Acta Biochimica et Biophysica Sinica》2015年第12期997-1004,共8页Shuo Li Linlin Wu Qingbing Wang Yingyi Li Xiaolin Wang 
Lysine （K）-specific demethylase 4B （KDM4B） is a histone H3K9 demethylase and is reported to acti- vate gene transcription through regulation of chromatin structures. Previous research has revealed that KDM4B plays...
关键词：pancreatic cancer KDM4B epithelial-mesenchymal transition ZEB1 TGF-Β 
Up-regulation of TIMP-2 expression promotes SHI-1 leukemic cells proliferation and infiltration in immunodeficiency mice被引量：1
《Chinese Medical Journal》2014年第24期4243-4249,共7页Li Zhenjiang Chen Zixing Cen Jiannong He Jun Qiu Qiaocheng Xue Yongquan 
This work was supported by the Grant from National Natural Science Foundation of China （No. 30670905）.
Background MMPs and TIMPs play important roles in tumor angiogenesis and invasion. Studies have shown that TIMP- 2 has two roles in tumor invasion. However, its role in leukemic infiltration has not been well investig...
关键词：acute monocytic leukemia extramedullary infiltration TIMP-2 nude mice model 
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