supported by the National Natural Science Foundation of China(82471819 and 81871227 to Z.C.);Anhui Provincial Health Research Foundation(AHWJ2023A10120 to Z.C.);Anhui Provincial Natural Science Foundation(2408085J046 to Z.C.);Anhui Provincial Key Research and Development Plan(2022h11020009 to Z.C.);the Fundamental Research Funds for the Central Universities(YD9110002012 to Z.C.).
Dear Editor,Rheumatoid arthritis(RA)is an autoimmune inflammatory disease characterized by symmetric synovial inflammation leading to progressive disability.1 Treatment of RA has been revolutionized by the development...
Clozapine is widely recognized as an effective antipsychotic medication for treatment-resistant schizophrenia, but it is typically associated with significant weight gain. This case report presents two unusual cases o...
Tumor heterogeneity can contribute to the development of therapeutic resistance in cancer, including advancedbreast cancers. The object of the Halifax project was to identify new treatments that would address mechanis...
Circulating tumour DNA(ctDNA)in blood plasma is an emerging tool for clinical cancer genotyping and longitudinal disease monitoring1.However,owing to past emphasis on targeted and low-resolution profiling approaches,o...
Major depressive disorder(MDD)is a common,serious,debilitating condition affecting 350 million people worldwide,which remains to be unsatisfactorily treated with 53%of patients still complaining of symptoms after comp...
financial support of this project received from Metromedia Bio-Science, LLC
Objective: The complexity, heterogeneity and capacity of malignant neoplastic cells and tumors for rapid change and evolution suggest that living-cell-based biological-systems approaches to cancer treatment are merit...
Aims: To retrospectively investigate the prevalence and characteristics of treatment-resistant hypertension (R-HT) among consecutive hypertensive outpatients, since patients with R-HT are candidates for catheter-based...
Comorbid anxiety with depression predicts poor outcomes with a higher percentage of treatment resistance than either disorder occurring alone. Overlap of anxiety and depression complicates diagnosis and renders treatm...
The treatment of refractory schizophrenia has been a clinical challenge for most psychiatrists; the possible reasons include diagnostic errors, medical conditions and brain dysgenesis. Here, we described a patient wit...