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  • 期刊=Signal Transduction and Targeted Therapyx
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Elimination of mutant SWI/SNF complexes by protein quality control: new opportunities targeting aggressive rhabdoid tumours
《Signal Transduction and Targeted Therapy》2024年第10期4151-4153,共3页Andreas Krämer Stefan Knapp 
German translational cancer network(DKTK),the Frankfurt Cancer Institute(FCI);German Cancer Aid(Krebshilfe)grant TACTIC and the SFB1430(Molecular Mechanisms of Cell State Transitions)。
A recent study published in Nature by Radko-Juettner and colleagues reports an unexpected mutant-specific synthetic lethality in which the E3 protein ubiquitin ligase DCAF5 specifically degrades mutant but not wild-ty...
关键词：TUMOUR LIKELY COMPLEXES 
RING finger 138 deregulation distorts NF-κB signaling and facilities colitis switch to aggressive malignancy被引量：1
《Signal Transduction and Targeted Therapy》2022年第7期2555-2567,共13页Yalan Lu Rong Huang Jianming Ying Xingchen Li Tao Jiao Lei Guo Haitao Zhou Han Wang Amannisa Tuersuntuoheti Jianmei Liu Qichen Chen Yanhong Wang Luying Su Changyuan Guo Fu Xu Ziyi Wang Yan Lu Kai Li Junbo Liang Zhen Huang Xiao Chen Jinjie Yao Hanjie Hu Xiaowen Cheng Yufeng Wan Xinyan Chen Ning Zhang Shiying Miao Jianqiang Cai Linfang Wang Changzheng Liu Wei Song Hong Zhao 
supported by CAMS Innovation Fund for Medical Sciences(CIFMS,2021-I2M-1-066,2017-I2M-4-002 to H.Z.,2021-I2M-1-019 to W.S.,2021-1-I2M-014 to C.Z.L.);the National Natural Science Foundation of China(81972311,82141127 and 81672461 to H.Z.,81672472,and 31970794 to W.S.,81570780 to C.Z.L.,32000586 to K.L.);the Nonprofit Central Research Institute Fund of Chinese Academy of Medical Sciences(2019PT310026 to H.Z.);Sanming Project of Medicine in Shenzhen(SZSM202011010 to H.Z.);the National Key Research and Development Program of China(2018YFC1003500 to W.S.);the State Key Laboratory Special fund from the Ministry of Science(2060204 to W.S.);the State Key Project on Infection Diseases of China(2017ZX10201021-007-003 to H.Z.).
Prolonged activation of nuclear factor(NF)-кB signaling significantly contributes to the development of colorectal cancer(CRC).New therapeutic opportunities are emerging from targeting this distorted cell signaling t...
关键词：MALIGNANCY SUSTAINED FINGER 
Correction: Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy被引量：1
《Signal Transduction and Targeted Therapy》2021年第3期1069-1069,共1页Ajaz A.Bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael El-Rifai Michael P.Frenneaux Surinder K.Batra Mohammad Haris Muzafar A.Macha 
Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-020-00419-w,published online 12 January 2021 After online publication of the article1,the authors noticed an error in affiliation o...
关键词：Cancer SQUAMOUS TARGETED 
Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy被引量：1
《Signal Transduction and Targeted Therapy》2021年第2期324-338,共15页Ajaz A.Bhat Parvaiz Yousuf Nissar A.Wani Arshi Rizwan Shyam S.Chauhan Mushtaq A.Siddiqi Davide Bedognetti Wael EI-Rifai Michael P.Frenneaux Surinder K.Batra Mohammad Haris Muzafar A.Macha 
This study was supported by Ramalingaswami Fellowship(Grant number:D.O.NO.BT/HRD/35/02/2006)from the Department of Biotechnology,Government of India,New Delhi to Muzafar A.Macha;Mohammad Haris is funded by a grant(5071012001)from Sidra Medicine Doha,Qatar;Ajaz A.Bhat is supported by Sidra Medicine internal grant(5011041002).We thank Dr.Vineeta Tanwar(Ohio State University,Columbus,Ohio,USA)for her professional assistance in editing the paper.
Head and neck squamous cell carcinoma(HNSCC)is a very aggressive disease with a poor prognosis for advanced-stage tumors.Recent clinical,genomic,and cellular studies have revealed the highly heterogeneous and immunosu...
关键词：TARGETED SQUAMOUS thereby 
Loss of mdig expression enhances DNA and histone methylation and metastasis of aggressive breast cancer被引量：2
《Signal Transduction and Targeted Therapy》2018年第1期81-89,共9页Chitra Thakur Bailing Chen Lingzhi Li Qian Zhang Zeng-Quan Yang Fei Chen 
This work was partially supported by NIH R01 ES017217,ES020137,ES028263,and P30 ES020957 to F.C.
We previously reported that expression of an environmentally induced gene,mineral dust-induced gene(mdig),predicts overall survival in breast cancer patients.In the present report,we further demonstrate the differenti...
关键词：BREAST METASTASIS INVASION 
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