PRION

作品数：173被引量：154H指数：5
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Activation of IP10/CXCR3 Signaling is Highly Coincidental with PrP^(Sc)Deposition in the Brains of Scrapie-Infected Mice
《Biomedical and Environmental Sciences》2024年第11期1235-1251,共17页Chen Jia Chen Cao Hu Chao Yang Wei Wang Lin Chen Dongdong Wu Yuezhang Shi Qi Dong Xiaoping 
supported by SKLID Development Grants(2021SKLID504,2019SKLID401,2019SKLID603,and 2016SKLID603);the National Natural Science Foundation of China(81772197,81401670,and 81630062)。
Objective To analyze the relationship between Chemokine IP10 and its receptor CXCR3 during prion infection.Methods We investigated the increases in IP10 signals,primarily localized in neurons within the brains of scra...
关键词：PRION Chemokine IP10 CXCR3 ACTIVATION 
Global Profiles of Acetylated Proteins in Brains of Scrapie Agents 139A- and ME7-Infected Mice Collected at Mid-Early, Mid-Late, and Terminal Stages
《Biomedical and Environmental Sciences》2022年第8期722-734,共13页SHI Qi CHEN Dong Dong ADALATI Maimaitiming XIAO Kang GAO Li Ping YANG Xue Hua WU Yue Zhang CHEN Cao DONG Xiao Ping 
supported by National Key R&D Program of China [2020YFE0205700];Chinese National Natural Science Foundation Grants [81630062];grants from the State Key Laboratory for Infectious Disease Prevention and Control(China CDC)[Grant Nos.2019SKLID501,2019SKLID603,and 2019SKLID307]
Objective To describe the global profiles of acetylated proteins in the brains of scrapie agents 139Aand ME7-infected mice collected at mid-early,mid-late,and terminal stages.Methods The acetylated proteins from the c...
关键词：PRION Scrapie-infected mouse Acetylation Proteomics Kyoto Encyclopedia of Genes and Genomes pathway 
Immune Responses in Wild-type Mice Against Prion Proteins Induced Using a DNA Prime-Protein Boost Strategy被引量：3
《Biomedical and Environmental Sciences》2011年第5期523-529,共7页HAN YanLing LI Yuan SONG Juan WANG Ying SHI Qi CHEN Cao ZHANG BaoYun GUO Yan LI ChaoPing HAN Jun DONG XiaoPing 
supported by Chinese National Natural Science Foundation Grants 30771914 and 30800975;Institution Technique R&D Grant (2008EG150300);National Basic Research Program of China (973 Program) (2007CB310505);China Mega-Project for Infectious Disease (2009ZX10004‐101, 2008ZX10004‐001, and 2008ZX10004‐002);the SKLID Development Grant (2008SKLID102 and 2008SKLID202)
Objective To break immune tolerance to prion （PrP） proteins using DNA vaccines.Methods Four different human prion DNA vaccine candidates were constructed based on the pcDNA3.1 vector：PrP‐WT expressing wild‐type P...
关键词：PRION DNA vaccine Humoral response T‐cell response Prime‐boosting regime. 
Treatment of Scrapie Pathogen 263K With Tetracycline Partially Abolishes Protease-resistant Activity in vitro and Reduces Infectivity in vivo被引量：1
《Biomedical and Environmental Sciences》2007年第3期198-202,共5页YAN-JUN GUO JUN HAN HAI-LAN YAO BAO-YUN ZHANG JIAN-MEI GAO JIN ZHANG XIN-LI XIAO XIAO-FAN WANG WEI-QIN ZHAO DE-XIN WANG XIAO-PING DONG 
This work was supported by National Natural Science Foundation of China,No.30130070;National 863 Project,No.2001AA215391;National Science and Technology Task Force Project,No.2001AA215391;EU Project QLRT,No.2000 01441.
Objective To study the possible effect of tetracycline on protease-resistant activity in vitro and infectivity in vivo of a scrapie strain 263K. Methods Scrapie pathogens were incubated with tetracycline at different ...
关键词：SCRAPIE PRION TETRACYCLINE Protease-resistant activity Animal experiment 
Establishment of Cell Free Conversion System With Biotin-labelled Recombinant PrP^(sen) Expressed in E.coli被引量：1
《Biomedical and Environmental Sciences》2006年第3期214-218,共5页JIN ZHANG JIAN-MEI GAO FENG LI JUN HAN LAN CHEN BAO-YUN ZHANG XIAO-FAN WAMG WEI ZHOU YONG LIU XIAO-PING DONG 
This work was supported by National Natural Science Foundation of China 30070038 and 30130070, National High-Tech Research and Development Program of China (863 Project) 2001AA215391, and EU Project QLRT 2000 01441.
Objective To report a protocol using biotin-labelled PrP protein in cell free conversion assay instead of isotope. Methods A hamster PrP protein （HaPrP） was expressed in E. coli and purified with HIS-tag affinity ch...
关键词：Transmissible spongiform eneephalopathies PRION BIOTIN Cell free conversion E. coli 
Dynamic Analyses of PrP and PrP^(Sc) in Brain Tissues of Golden Hamsters Infected With Scrapie Strain 263K Revealed Various PrP Forms被引量：14
《Biomedical and Environmental Sciences》2004年第1期8-20,共13页JIAN-MEIGAO CHENGAO JUNHAN XIAO-BOZHOU XIN-LIXIAO JINZHANG LANCHEN BAO-YUNZHANG TAOHONG XIAO-PINGDONG 
This work was supported by the National Natural Science Foundation of China, No. 39928018, 30070038 and 30130070, National High-tech Research Development Program (863 Program), No. 2001AA215391, and EU Project QLRT, No. 200001441.
Objective To expatiate dynamic changes in hamsters infected with scrapie strain 263K, to observe the presence and aggravation of various forms of PrP and PrPSc during incubation period, and to probe primarily the rela...
关键词：Transmissible spongiform encephalopathies (TSEs) PRION SCRAPIE GLYCOSYLATION Scrapie-associated fibril (SAF) 
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