云南高校图书馆联盟文献共享服务平台- SCRAPIE

SCRAPIE: 作品数：13被引量：21H指数：2; 导出分析报告; 相关领域：医药卫生农业科学更多>>; 相关作者：周荣艳王志亮刘雨田李兰会王桂荣更多>>; 相关机构：中国疾病预防控制中心东南大学农业部动物检疫所上海第二医科大学更多>>; 相关期刊：《中国动物检疫》《Open Journal of Animal Sciences》《Biosafety and Health》《Neural Regeneration Research》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划引进国际先进农业科技计划更多>>

Activation of IP10/CXCR3 Signaling is Highly Coincidental with PrP^(Sc)Deposition in the Brains of Scrapie-Infected Mice: 《Biomedical and Environmental Sciences》2024年第11期1235-1251,共17页Chen Jia Chen Cao Hu Chao Yang Wei Wang Lin Chen Dongdong Wu Yuezhang Shi Qi Dong Xiaoping; supported by SKLID Development Grants(2021SKLID504,2019SKLID401,2019SKLID603,and 2016SKLID603);the National Natural Science Foundation of China(81772197,81401670,and 81630062)。; Objective To analyze the relationship between Chemokine IP10 and its receptor CXCR3 during prion infection.Methods We investigated the increases in IP10 signals,primarily localized in neurons within the brains of scra...; 关键词：PRION Chemokine IP10 CXCR3 ACTIVATION

Global Profiles of Acetylated Proteins in Brains of Scrapie Agents 139A- and ME7-Infected Mice Collected at Mid-Early, Mid-Late, and Terminal Stages: 《Biomedical and Environmental Sciences》2022年第8期722-734,共13页SHI Qi CHEN Dong Dong ADALATI Maimaitiming XIAO Kang GAO Li Ping YANG Xue Hua WU Yue Zhang CHEN Cao DONG Xiao Ping; supported by National Key R&D Program of China [2020YFE0205700];Chinese National Natural Science Foundation Grants [81630062];grants from the State Key Laboratory for Infectious Disease Prevention and Control(China CDC)[Grant Nos.2019SKLID501,2019SKLID603,and 2019SKLID307]; Objective To describe the global profiles of acetylated proteins in the brains of scrapie agents 139Aand ME7-infected mice collected at mid-early,mid-late,and terminal stages.Methods The acetylated proteins from the c...; 关键词：PRION Scrapie-infected mouse Acetylation Proteomics Kyoto Encyclopedia of Genes and Genomes pathway

Astrocyte in prion disease: a double-edged sword被引量：2: 《Neural Regeneration Research》2022年第8期1659-1665,共7页Waqas Tahir Simrika Thapa Hermann M.Schatzl; supported by grants from Alberta Innovates/Alberta Prion Research Institute(APRI grants 201600010 and 201900008)(to HMS);ST had received a University of Calgary Eyes High,Killam and Alberta Innovates Health Solution(AIHS)doctoral fellowship.; Prion diseases are infectious protein misfolding disorders of the central nervous system that result from misfolding of the cellular prion protein(PrPC)into the pathologic isoform PrPSc.Pathologic hallmarks of prion d...; 关键词：Alzheimer’s disease ASTROCYTES central nervous system Creutzfeldt-Jakob disease glial cells NEURODEGENERATION PRION prion disease prion protein SCRAPIE

Therapeutic implications of prion diseases被引量：1: 《Biosafety and Health》2021年第2期92-100,共9页Cao Chen Xiaoping Dong; supported by the National Natural Science Foundation of China(grant nos.81772197,81401670,81630062);National Key R&D Program of China(grant no.2018YFC1200305);National Science and Technology Major Project of China(grant no.2018ZX10102001);SKLID Development Grant(grant nos.2019SKLID401,2019SKLID603,2016SKLID603);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(grant no.2018RC330004),。; Prions are unconventional infectious agents that cause lethal transmissible neurodegenerative diseases in human and animals.Prions can be distinguished fromother knownpathogens by their lack of nucleic acids.The most ...; 关键词：Prion disease Normal cellular prion protein Pathogenic scrapie prion protein IMMUNOTHERAPY Natural extracts

PrP Gene Polymorphism in Medieval Remains of Sicilian Sheep: 《Open Journal of Animal Sciences》2015年第4期486-494,共9页Stefano Reale Mario Cosenza Luca Sìneo Letizia Arcoleo Gabriele Zaffora Daniele Macrì Fabrizio Vitale; Encephalopathy in sheep was at first described in Ireland in 1732 and was called scrapie. Ancient DNA in archaeogenetics represents an effective method to evaluate the ancestral pedigree of living animals and track ev...; 关键词：SCRAPIE PRION Protein SNPs Ancient GENOTYPE

Using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to analyze differentially expressed brain polypeptides in scrapie strain 22L-infected BALB/c mice被引量：1: 《Neural Regeneration Research》2011年第23期1801-1805,共5页Xiangyu Liao Jiayu Wan Wensen Liu Xin Tang Wufei Zhu Na XU Jing Xu Nan Li Yaping Chang Chuanjing Ju; the National Natural Science Foundation of China,No. 30972197 and 31072148;Science and Technology Plan Program of Jilin Province,No. 201105038; Differentialiy expressed polypeptides in the brain of a BALB/c mouse model infected with scrapie strain 22L were analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The results sh...; 关键词：prion diseases misfolded prion protein imaging mass spectrometry PEPTIDES biological markers mass spectrometry

Establishment of a Stable PrP^(Sc) Panel from Brain Tissues of Experimental Hamsters with Scrapie Strain 263K被引量：1: 《Biomedical and Environmental Sciences》2009年第2期151-156,共6页BAO-YUN ZHANG CHAN TIAN JUN HAN CHEN GAO QI SHI JIAN-MING CHEN HUI-YING JIANG WEI ZHOU AND XIAO-PING DONG; supported by National Science and Technology Task Force Project (2006BAD06A13-2);National Basic Research Program of China (973 Program) (2007CB310505);Institution Technique R&D Grand (2008EG150300);National Natural ScienceFoundation of China (Grants 30571672, 30500018, 30771914, and 30800975); Objective To establish a stable PrP^Sc panel from brain tissues of experimental hamsters infected with scrapie agent 263K for evaluating diagnostic techniques of human and animals＇ prion diseases. Methods Thirty brai...; 关键词：TSE prp^Sc PANEL GLYCOFORMS Stability

Establishment of the Method of Immunohistochemistry Assay for the Detection of Scrapie in Chinese Short-Tailed Han Sheep by Monoclonal Antibody: 《Agricultural Sciences in China》2008年第12期1516-1523,共8页ZHANG Yong-qiang WANG Zhi-liang WU Xiao-dong LIU Yu-tian ZHANG Hai-tao BAO En-dong; the National Natural Sci-ence Foundation of China (C02030606);948 Project from Agriculture Ministry of China (2001-366); The method of immunohistochemistry assay for the detection of scrapie in Chinese Short-tailed Han sheep was established using monoclonal antibody. Genomic DNA was isolated from Chinese Short-tailed Hart sheep blood. U...; 关键词：Chinese Short-tailed Han sheep PrP27-30 SCRAPIE monoclonal antibody immunohistochemistry assay

Treatment of Scrapie Pathogen 263K With Tetracycline Partially Abolishes Protease-resistant Activity in vitro and Reduces Infectivity in vivo被引量：1: 《Biomedical and Environmental Sciences》2007年第3期198-202,共5页YAN-JUN GUO JUN HAN HAI-LAN YAO BAO-YUN ZHANG JIAN-MEI GAO JIN ZHANG XIN-LI XIAO XIAO-FAN WANG WEI-QIN ZHAO DE-XIN WANG XIAO-PING DONG; This work was supported by National Natural Science Foundation of China,No.30130070;National 863 Project,No.2001AA215391;National Science and Technology Task Force Project,No.2001AA215391;EU Project QLRT,No.2000 01441.; Objective To study the possible effect of tetracycline on protease-resistant activity in vitro and infectivity in vivo of a scrapie strain 263K. Methods Scrapie pathogens were incubated with tetracycline at different ...; 关键词：SCRAPIE PRION TETRACYCLINE Protease-resistant activity Animal experiment

免疫组织化学方法检测牛海绵状脑病(BSE)和羊痒病(Scrapie): 《中国动物检疫》2004年第3期20-23,共4页刘雨田吴晓东邹艳丽王志亮; 国家自然科学基金(30270981);农业部"948"项目(982070);"十五"青岛市科技发展计划重点课题 (2001KNS-2N-53)资助; 按照本实验室建立的牛海绵状脑病免疫组织化学方法 ,将自制单克隆抗体4C11与PK酶消化处理的牛海绵状脑病阳性切片和羊痒病阳性切片进行反应 ,发现单抗4C11不仅能与牛海绵状脑病阳性切片发生强烈的免疫反应 ,而且也能与羊痒病阳性切片发...; 关键词：免疫组织化学方法牛海绵状脑病 BSE 羊痒病 SCRAPIE 检测技术

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