DOUBLE-STRANDED

作品数：34被引量：43H指数：4
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相关领域：生物学医药卫生更多>>
相关作者：何玉科吴斐婕更多>>
相关机构：中国科学院上海生命科学研究院更多>>
相关期刊：《Chinese Journal of Structural Chemistry》《Science Bulletin》《World Journal of Biological Chemistry》《Journal of Biomaterials and Nanobiotechnology》更多>>
相关基金：国家自然科学基金广东省自然科学基金国家高技术研究发展计划中国博士后科学基金更多>>
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One step at a time:new insights into double-stranded ribonucleic acid virus assembly
《Signal Transduction and Targeted Therapy》2024年第10期4160-4161,共2页Virgile Rat Alexander Borodavka Don C.Lamb 
Open Access funding enabled and organized by Projekt DEAL.
In a recent paper published in Cell,Xia et al.1 carried out 3D reconstructions of Blue Tongue Virus(BTV)particles and their assembly intermediates using a combination of cellular cryo-electron tomography(Cryo-ET)and s...
关键词：DOUBLE ASSEMBLY INSIGHT 
Bioinspired Double-stranded Yarn with Alternating Hydrophobic/Hydrophilic Patterns for High-efficiency Fog Collection
《Chinese Journal of Polymer Science》2024年第7期968-975,I0008,共9页Lan-Lan Hou Meng-Na Qiu Ya-Qiong Wang Tong-Hua Bai Zhi-Min Cui Jing-Chong Liu Ying-Qun Qi Nü Wang Yong Li Yong Zhao 
financially supported by the National Natural Science Foundation of China(Nos.22105012,21975007,22175007 and 52172080);Beijing Natural Science Foundation(Nos.2242035,2242041,2232054 and 2232037);the National Natural Science Foundation for Outstanding Youth Foundation;the Fundamental Research Funds for the Central Universities;the National Program for Support of Top-notch Young Professionals;the 111 project(No.B14009);the Youth Excellence Project of Beijing Institute of Graphic Communication(No.Ea202403);the Scientific Research Foundation of Beijing Institute of Graphic Communication(No.27170124031)。
Efforts to develop innovative water harvesting strategies offer powerful solutions to alleviate the water crisis,especially in remote and arid areas.Inspired by the hydrophobic/hydrophilic pattern of desert beetles an...
关键词：Fog collection Wettability Electrospinning Nanofibers Spider silk 
Chromatin compartments at DNA double-stranded breaks
《Cell Research》2024年第5期337-338,共2页Jaewon Min Jean Gautier 
In a recent article published in Nature,Arnould and colleagues reveal that DNA double-stranded breaks(DSBs)strengthen chromatin compartmentalization near the breaks.They show that"D"compartments arise from clustering ...
关键词：DOUBLE thereby BREAKS 
Differentiated self-assembly through orthogonal noncovalent interactions towards the synthesis of two-dimensional woven supramolecular polymers
《Chinese Chemical Letters》2024年第5期179-182,共4页Zhenzhu Wang Chenglong Liu Yunpeng Ge Wencan Li Chenyang Zhang Bing Yang Shizhong Mao Zeyuan Dong 
supported by the National Natural Science Foundation of China(Nos.92156012 and 22071078).
Molecular weaving is a powerful approach to make molecularly woven materials that have showed unprecedented characteristics and properties intrinsically distinct to those of non-woven materials.We here report a facile...
关键词：Differentiated self-assembly Double-stranded helix Molecular weaving Supramolecular chemistry Two-dimensional polymer 
Blocking Translation of Oncogenic mRNA
《Journal of Cancer Therapy》2023年第6期233-256,共24页Kelvin N. Christie 
Double-stranded RNA-mediated interference (RNAi), antisense oligonucleotides (ASO), and ribozymes have excellent specificity to their target oncogenic mRNA. They also seem to show great promise when it comes to treati...
关键词：Antisense Oligonucleotides RIBOZYMES PHOSPHOROTHIOATE Double-Stranded RNA-Mediated Interference NUCLEASES 
Exposure to Long Magnetic Resonance Imaging Thermometry Does Not Cause Significant DNA Double-Strand Breaks on CF-1 Mice
《Journal of Modern Physics》2022年第6期839-850,共12页Christopher Brian Abraham Sepideh Dadgar Wely B. Floriano Michael Campbell Laura Curiel 
The purpose of the study was to investigate if the high gradient strength and slew rate used for long MRI-thermometry monitoring could cause DNA double-stranded breaks (DSBs). To this end, an enzyme-linked immunosorbe...
关键词：γH2AX DNA Damage MRI Thermometry GADOLINIUM Double-Stranded Breaks (DSBs) ELISA Ionizing Radiation 
Extending the L1 region in canonical double-stranded RNA-binding domains impairs their functions
《Acta Biochimica et Biophysica Sinica》2021年第4期463-471,共9页Xiaoxiao Zhang Peng Li Huanhuan Zhong Fanming Yang Fanzhou Liu Gabriel Yedid Yan Zeng 
This work was supported in part by the grants from the National Natural Science Foundation of China(Nos.31470435 and 31570843).
A large number of proteins involved in RNA metabolism possess a double-stranded RNA-binding domain(dsRBD),whose sequence variations and functional versatilities are still being recognized.All dsRBDs have a similar str...
关键词：double-stranded RNA-binding domain DROSHA microRNA DICER 
Electrochemical,spectroscopic,and molecular docking studies of the interaction between the anti-retroviral drug indinavir and dsDNA
《Journal of Pharmaceutical Analysis》2020年第5期473-481,共9页Fariba Mollarasouli Burcu Dogan-Topal Mehmet Gokhan Caglayan Tugba Taskin-Tok Sibel A.Ozkan 
In this study,an electrochemical DNA biosensor was developed using a straightforward methodology to investigate the interaction of indinavir with calf thymus double-stranded deoxyribonucleic acid(ctdsDNA)for the first...
关键词：Glassy carbon electrode Calf thymus double-stranded deoxyribonucleic acid(ct-dsDNA) BIOSENSOR Fluorescence Molecular docking 
CAS9 is a genome mutator by directly disrupting DNA-PK dependent DNA repair pathway被引量：9
《Protein & Cell》2020年第5期352-365,共14页Shuxiang Xu Jinchul Kim Qingshuang Tang Qu Chen Jingfeng Liu Yang Xu Xuemei Fu 
This study was supported by the a grant from the National High-tech R&D Program(863 Program No.2015AA020310);National Natural Science Foundation of China(Nos.815300045,91959204,81930084,81871197,U1601222);the leading talents of Guangdong Province Program(No.00201516);a grant from the Key Research and Development Program of Guangdong Province(2019B020235003);Major basic research developmental project of the Natural Science Foundation of Guangdong Province(2014A030308018);Development and Reform Commission of Shenzhen Municipality(S2016004730009);Shenzhen“Sanming”Project of Medicine(SZSM201602102).
With its high efficiency for site-specific genome editing and easy manipulation,the clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR associated protein 9(CAS9)system has become the most widely ...
关键词：KEYWORDS CAS9 DNA-PK DNA double-stranded breaks genetic instability DNA repair 
Refined spatial temporal epigenomic profiling reveals intrinsic connection between PRDM9-mediated H3K4me3 and the fate of double-stranded breaks被引量：5
《Cell Research》2020年第3期256-268,共13页Yao Chen Ruitu Lyu Bowen Rong Yuxuan Zheng Zhen Lin Ruofei Dai Xi Zhang Nannan Xie Siqing Wang Fuchou Tang Fei Lan Ming-Han Tong 
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19000000);the National Key R&D Program of China(2016YFC1000605 and 2018YFC1003401);the National Natural Science Foundation of China(31930034 and 31671553);the Science and Technology Commission of Shanghai Municipality(17JC1420102 and 19JC1415800);supported by the National Key R&D Program of China(2016YFA0101800 and 2018YFA0108700);the National Natural Science Foundation of China(31925010 and 91953121);Shanghai Municipal Science and Technology Major Project(2017SHZDZX01);supported by the National Natural Science Foundation of China(31625018);supported by the China Postdoctoral Science Foundation(2019M651607)。
Meiotic recombination is initiated by the formation of double-strand breaks(DSBs),which are repaired as either crossovers(COs)or noncrossovers(NCOs).In most mammals,PRDM9-mediated H3K4me3 controls the nonrandom distri...
关键词：double CROSSOVER OCCUPY 
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