GLYCOENGINEERING

作品数：7被引量：9H指数：2
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相关期刊：《Frontiers of Chemical Science and Engineering》《Neural Regeneration Research》《Chinese Journal of Chemistry》《Chinese Chemical Letters》更多>>
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Tumor Cell-Specific Metabolic Labelling of Surface Sialoglycans and Post-Click with Multivalent Rhamnose Enable Precise Immune Killing by Endogenous Antibody
《Chinese Journal of Chemistry》2025年第1期46-52,共7页Haofei Hong Yanchun Li Dan Li Han Lin Jie Zhao Zheng Wang Zhimeng Wu 
supported by the National Natural Science Foundation of China(No.22177040);partly funded by the Fundamental Research Funds for the Central Universities(No.JUSRP123037);the 111 Project(No.111-2-06).
We report the design and development of aβ-glucuronidase(β-Glu)-responsive ManNAz derivative,Glu-AAM,for tumor-selective metabolic glycoengineering.Glu-AAM enables specific labeling of tumor cell surface sialoglycan...
关键词：Metabolic glycoengineering Β-GLUCURONIDASE Antibody recruitment Multivalent rhamnose Cancer immunotherapy Bioimaging CLICKCHEMISTRY Carbohydrates 
Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy
《Frontiers of Chemical Science and Engineering》2023年第4期483-489,共7页Lan Lin Lai Jiang En Ren Gang Liu 
supported by the Major State Basic Research Development Program of China (Grant No.2017YFA0205201);the National Natural Science Foundation of China (Grant Nos.81925019 and U1705281).
Benefiting from the advantage of taking place in biological environments without interfering with an innate biochemical process,the bioorthogonal reaction that commonly contains the“bond formation”and“bond cleavage...
关键词：bioorthogonal reaction cancer therapy metabolic glycoengineering bioorthogonal catalytic patch 
One-step synthesis of site-specific antibody-drug conjugates by reprograming IgG glycoengineering with LacNAc-based substrates被引量：2
《Acta Pharmaceutica Sinica B》2022年第5期2417-2428,共12页Wei Shi Wanzhen Li Jianxin Zhang Tiehai Li Yakai Song Yue Zeng Qian Dong Zeng Lin Likun Gong Shuquan Fan Feng Tang Wei Huang 
supported by the National Natural Science Foundation of China(NSFC,No.,2187116 and 82003574);Shanghai Municipal Science and Technology Major Project,the Shanghai Sail Program(No.19YF1457100);the Special Research Assistant Program(Chinese Academy of Sciences,CAS),Natural Science Foundation of Shandong Province(ZR2017BC062)。
Glycosite-specific antibody-drug conjugatess(gsADCs), harnessing Asn297 N-glycan of IgG Fc as the conjugation site for drug payloads, usually require multi-step glycoengineering with two or more enzymes, which limits ...
关键词：Site-specific ADCs ENGase LacNAc One-step assembly Potent in vivo efficacy 
Synthesis of DNP-modified GM3-based anticancer vaccine and evaluation of its immunological activities for cancer immunotherapy
《Chinese Chemical Letters》2021年第12期4041-4044,共4页Han Lin Haofei Hong Lipeng Feng Jie Shi Zhifang Zhou Zhimeng Wu 
supported by the National Natural Science Foundation of China (Nos. 21907038, 32000904);the Natural Science Foundation of Jiangsu Province (No. BK20200601, China);the National Postdoctoral Program for Innovative Talents of China (No. BX20200153);the Health and Family Planning Commission of Wuxi, China (No. Z202005);the Social Development Key Project of Jiangsu Province (No. BE2019632, China);partly supported by the 111 Project (No. 111-2-06, China);the National First-class Discipline Program of Food Science and Technology (No. JUFSTR20180101, China)。
Tumor-associated carbohydrate antigens(TACAs) are attractive targets for vaccine development. In this context, we described a strategy combining artificial TACA and glycoengineering for cancer vaccine development. A 2...
关键词：GM3 Cancer vaccine Anti-DNP antibodies GLYCOENGINEERING Tumor-associated carbohydrate antigen 
Glycosylation engineering of therapeutic IgG antibodies： challenges for the safety, functionality and efficacy被引量：6
《Protein & Cell》2018年第1期47-62,共16页Yusuke Mimura Toshihiko Katoh Radka Saldova Roisin O'Flaherty Tomonori Izumi Yuka Mimura-Kimura Toshiaki Utsunomiya Yoichi Mizukami Kenji Yamamoto Tsuneo Matsumoto Pauline M. Rudd 
Glycosylation of the Fc region of IgG has a profound impact on the safety and clinical efficacy of therapeutic antibodies. While the biantennary complex.type oligosaccharide attached to Asn297 of the Fc is essen- tial...
关键词：chemoenzymatic glycoengineering crysta structure endoglycosidase FUCOSE glycosylation intravenous immunoglobulin sialic acid transglycosylation ultra performance liquid chromatography 
N-Propionylmannosamine:using biochemical glycoengineering to promote peripheral nerve regeneration
《Neural Regeneration Research》2015年第12期1947-1948,共2页Georgios Koulaxouzidis Werner Reutter Christian Witzel 
The peripheral nervous system,in contrast to the central nervous system,is capable of spontaneous regeneration.However,nerve reconstruction in the peripheral nervous system remains a major challenge,as the functional ...
关键词：N-Propionylmannosamine FIGURE Man ST UDP acid 
N-Propionylmannosamine stimulates axonal elongation in a murine model of sciatic nerve injury被引量：1
《Neural Regeneration Research》2015年第6期976-981,共6页Christian Witzel Werner Reutter G.Bj?rn Stark Georgios Koulaxouzidis 
Increasing evidence indicates that sialic acid plays an important role during nerve regeneration. Sialic acids can be modified in vitro as well as in vivo using metabolic oligosaccharide engineering of the N-awl side ...
关键词：N-propionylmannosamine sialic acid GLYCOENGINEERING sciatic nerve peripheral nerve branching arborisation Thyl-YFP mouse nerve regeneration 
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