PHOSPHODIESTERASE

作品数：79被引量：148H指数：6
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相关领域：医药卫生更多>>
相关作者：朱永通徐雯曹云燕崔倩倩蔡圣朝更多>>
相关机构：南方医科大学南方医院浙江大学安徽中医药大学华中农业大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划国家科技支撑计划北京市自然科学基金更多>>
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Phosphodiesterase 10A inhibitor PF-2545920 as a prospective agent for the clinical promotion of sperm motility
《Asian Journal of Andrology》2023年第5期608-615,共8页Yi-Ting Yang Bin Yan Yu-Hua Li Li-Na Guo Wei-Wei Wang Li-Jie Liu He-Guo Yu Hua Diao 
supported by the Shanghai Municipal Health Commission Young Foundation(No.20194Y0270);Science and Technology Commission of Shanghai Municipality(No.20ZR1448100).
Phosphodiesterase(PDE)inhibitors can improve sperm motility in patients with asthenozoospermia.However,the most commonly reported nonselective PDE inhibitor pentoxifylline and PDE5 inhibitor sildenafil have the disadv...
关键词：PENTOXIFYLLINE phosphodiesterase 10A SILDENAFIL sperm motility spontaneous acrosome reaction 
The effects of single versus combined therapy using LIM-kinase 2 inhibitor and type 5 phosphodiesterase inhibitor on erectile function in a rat model of cavernous nerve injury-induced erectile dysfunction被引量：1
《Asian Journal of Andrology》2019年第5期493-500,共8页Min Chui Cho Junghoon Lee Juhyun Park Sohee Oh Ji Sun Chai Hwancheol Son Jae-Seung Paick Soo Woong Kim 
We aimed to determine whether combination of LIM-kinase 2 inhibitor(LIMK2i)and phosphodiesterase type-5 inhibitor(PDE5i)could restore erectile function through suppressing cavernous fibrosis and improving caver nous a...
关键词：apoptosis erectile DYSFUNCTION FIBROSIS LIM KINASE PHOSPHODIESTERASE 
Combination therapy for erectile dysfunction： an update review被引量：7
《Asian Journal of Andrology》2011年第3期382-390,510,511,共11页Rohit R Dhir Hao-Cheng Lin Steven E Canfield Run Wang 
The introduction of oral phosphodiesterase-5 inhibitors （PDE51s） in the late 1990s and early 2000s revolutionized the field of sexual medicine and PDE51s are currently first-line monotherapy for erectile dysfunction...
关键词：combination therapy intracavernosal injection erectile dysfunction phosphodiesterase-5 inhibitors vacuum erectile device 
Homocysteine and copper interact to promote type 5 phosphodiesterase expression in rabbit cavernosal smooth muscle cells被引量：7
《Asian Journal of Andrology》2008年第6期905-913,共9页Matthew Hotston Jamie Y. Jeremy Jonathon Bloor Nick S. Greaves Raj Persad Gianni Angelini Nilima Shukla 
Aim： To study the effects of homocysteine and copper on type 5 phosphodiesterase （PDE5） expression in cavemosai vascular smooth muscle cells （CVSMCs） and to investigate superoxide （O2-） derived from nicotinamid...
关键词：erectile dysfunction superoxide PDE5 SILDENAFIL 
Efficacy and safety of oral SK3530 for the treatment of erectile dysfunction in Korean men： a multicenter, randomized, doubleblind, placebo-controlled, fixed dose, parallel group clinical trial被引量：3
《Asian Journal of Andrology》2008年第5期791-798,共8页Jae-Seung Paick Hyung-Ki Choi Sae-Chul Kim Tai-Young Ahn Je-Jong Kim Jong-Kwan Park Kwang-Sung Park Sung-Won Lee Sae-Woong Kim Kwanjin Park Hyonggi Jung Nam-Cheol Park 
Aim： To evaluate the efficacy and safety of SK3530, a newly developed type 5 phosphodiesterase inhibitor （PDE5I）, in Korean men with erectile dysfunction （ED）. Methods： A total of 119 patients were randomized at...
关键词：erectile dysfunction PHOSPHODIESTERASE sildenafil citrate 
Improved spontaneous erectile function in men with mild-tomoderate arteriogenic erectile dysfunction treated with a nightly dose of sildenafil for one year： a randomized trial被引量：12
《Asian Journal of Andrology》2007年第1期134-141,共8页Frank Sommer Theodor Klotz Udo Engelmann 
Aim： To test the hypothesis that sildenafil （50 mg nightly for one year） can improve spontaneous erectile function （EF） in men with mild-to-moderate arteriogenic erectile dysfunction （ED） responsive to erectoge...
关键词：PHOSPHODIESTERASE sexual dysfunctions PSYCHOLOGICAL sildenafil citrate erectile funcion 
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