PROTO-ONCOGENE

作品数：47被引量：151H指数：7
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相关领域：医药卫生生物学更多>>
相关作者：刘君程雁陈晓红董薇张均田更多>>
相关机构：南京医科大学首都医科大学附属北京安贞医院首都医科大学中国医学科学院北京协和医学院更多>>
相关期刊：《Cellular & Molecular Immunology》《Science China(Life Sciences)》《Chinese Journal of Integrative Medicine》《中国组织化学与细胞化学杂志》更多>>
相关基金：国家自然科学基金湖北省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Therapeutic insights into epidermal growth factor receptor/reactive oxygen species proto-oncogene 1-receptor co-mutated non-small cell lung cancer:Crizotinib as a promising option
《World Journal of Clinical Oncology》2025年第3期190-193,共4页Yan Zhou Bo-Tao Xu Hai-Ying Zhou Zhong-Tu Shang 
This letter provides a review of the report by Peng et al on a unique case of non-small cell lung cancer(NSCLC),specifically lung adenocarcinoma,featuring reactive oxygen species proto-oncogene 1-receptor(ROS1)co-muta...
关键词：ADENOCARCINOMA CRIZOTINIB Genetic heterogeneity Lung cancer Mutation Personalized medicine 
Highly expression of MYBL2 is correlated with a poor prognosis and immune infiltration in clear cell renal carcinoma
《Medical Data Mining》2022年第4期1-15,共15页Yu-Xin Chen Jun Pan Hong-Qian Guo Wei-Dong Gan 
supported by the Key Medical Research Projects of Jiangsu Commission of Health(ID:2022013).
Background:Clear cell renal carcinoma(ccRCC)is notorious for its highly unfavorable prognosis,closely related to immune cell infiltration(ICI).MYB Proto-Oncogene Like 2(MYBL2)is elevated in multiple types of human can...
关键词：MYB Proto-Oncogene Like 2 clear cell renal carcinoma completing endogenous RNA immune infiltration 
ETS proto-oncogene 1 modulates PTP1B expression to participate in high glucose-mediated endothelial inflammation被引量：1
《Acta Biochimica et Biophysica Sinica》2022年第4期565-573,共9页Lili Jiang Jincai Liang Tianhai Wang Fufen Meng Wenming Duan 
the grant from the Initiating Fund of the Natural Science Foundation of Xinjiang Uygur Autonomous Region(No.2019D01C257)。
Hyperglycemia-induced endothelial inflammation participates in the pathogenesis of cardiovascular complications in diabetics.Previous studies showed that protein tyrosine phosphatase 1B(PTP1B)and ETS proto-oncogene 1(...
关键词：ENDOTHELIAL ETS1 high glucose INFLAMMATION PTP1B 
The SKI proto-oncogene restrains the resident CD103^(+)CD8^(+) T cell response in viral clearance被引量：1
《Cellular & Molecular Immunology》2021年第10期2410-2421,共12页Bing Wu Ge Zhang Zengli Guo Gang Wang Xiaojiang Xu Jian-liang Li Jason K.Whitmire Junnian Zheng Yisong Y.Wan 
This work was supported by NIH funding(R01Al143894,R01Al138337)for J.K.W.;the NIH(Al123193);the National Multiple Sclerosis Society(RG-1802-30483);the Yang Family Biomedical Scholars Award for Y.Y.W.
Acute viral infection causes illness and death.In addition,an infection often results in increased susceptibility to a secondary infection,but the mechanisms behind this susceptibility are poorly understood.Since its ...
关键词：CD103 TGFΒ SKI SMAD4 LCMV infection Histone acetylation 
Proliferating cell nuclear antigen clamp associated factor,a potential proto-oncogene with increased expression in malignant gastrointestinal tumors被引量：2
《World Journal of Gastrointestinal Oncology》2021年第10期1425-1439,共15页Li-Juan Liu Jian-Ming Liao Fan Zhu 
the National Natural Science Foundation of China,No.81971943 and No.81772196;and the Hubei Provincial Natural Science Foundation of China,No.2020CFB656.
Gastrointestinal(GI)cancers,including malignancies in the gastrointestinal tract and accessory organs of digestion,represent the leading cause of death worldwide due to the poor prognosis of most GI cancers.An investi...
关键词：Proliferating cell nuclear antigen Proliferating cell nuclear antigen clamp associated factor Transcript variant Gastrointestinal cancers Signal pathway Biological therapeutic 
Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review被引量：7
《World Journal of Clinical Oncology》2020年第1期31-42,共12页Rogelio González-González Sandra López-Verdín Jesús Lavalle-Carrasco Nelly Molina-Frechero Mario Isiordia-Espinoza Ramón G Carreón-Burciaga Ronell Bologna-Molina 
BACKGROUND Ameloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment strategies.Different signaling pathways that participate in ...
关键词：AMELOBLASTOMA B-raf proto-oncogene serine/threonine kinase B-raf protooncogene serine/threonine kinase V600E Additional mutations Targeted therapies 
Effects of electroacupuncture at Taichong(LR 3) and Baihui(DU 20)on cardiac hypertrophy in rats with spontaneous hypertension被引量：9
《Journal of Traditional Chinese Medicine》2019年第4期502-508,共7页Ji Zhi Zhang Yue Liang Jingrong Wu Jiaojuan Jia Wenrui Wang Zhaoyang Liu Qingguo 
Supported by Beijing Natural Science Foundation:Regulating effect of electroacupuncture on cardiac hypertrophy of spontaneously hypertensive rats based on PI3K/AKT signal transduction pathway(No.7162121);Young Teacher Program of Beijing University of Chinese Medicine:Mechanism of acupuncture on left ventricular remodeling in spontaneously hypertensive rats based on microRNA-195 targeting TGF/Smads signaling pathway(No.2017-JYB-JS-030)
OBJECTIVE: To investigate the effects of electroacupuncture(EA) at Taichong(LR 3) and Baihui(DU 20)on myocardial hypertrophy in spontaneously hypertensive rats(SHRs).METHODS: Thirty-six SHRs were randomly assigned to ...
关键词：ELECTROACUPUNCTURE Rats inbred SHR Hypertrophy PHOSPHATIDYLINOSITOL 3-kinases PROTO-ONCOGENE proteins c-akt Mammalian target of rapamycin 
Spleen-kidney supplementing formula alleviates insulin resistance via regulating AKT/glycogen synthase kinase 3β pathway in rats with type 2 diabetic induced by high-fat diet被引量：4
《Journal of Traditional Chinese Medicine》2019年第2期199-206,共8页Tian Chunyu Wang Ya La Xiaojin Li Ji'an Zhang Biwei 
Supported by Key Program of Science and Technology Research of Higher Education Institutions in Hebei Province(No.Zd2018215);Doctoral Scientific Research Fund of North China University of Science and Technology(No.BS2017064)
OBJECTIVE: To explore the molecular mechanism underpinning the action by investigating its effect on glycogen content and AKT(also known as protein kinase B)/glycogen synthase kinase 3β(GSK-3β) pathway in the liver ...
关键词：Spleen-kidney supplementing FORMULA Insulin resistance PROTO-ONCOGENE proteins c-akt Glycogen Phosphorylation 
Predictive Value of BRAF^V600E Mutation for Lymph Node Metastasis in Papillary Thyroid Cancer:A Meta-analysis被引量：18
《Current Medical Science》2018年第5期785-797,共13页Jing-yong SONG Shi-ran SUN Fang DONG Tao HUANG Bin WU Jing ZHOU 
This study was supported by National Natural Science Foundation of China (No.81702650),Natural Science Foundation of Hubei Province (No.2016CFB323)and Innovation Foundation of Huazhong University of Science and Technology (No.2016YXMS229).
BRAF^V600E mutation has been thought to be a valuable molecular marker that may predict a worse prognosis for papillary thyroid cancer (PTC).But whether BRAF^V600E mutation is associated with lymph node metastasis (LN...
关键词：B-RAF PROTO-ONCOGENE THYROID cancer PAPILLARY THYROID carcinoma LYMPH node metastasis META-ANALYSIS 
Research progress of SALL4 gene in human malignant tumor
《Discussion of Clinical Cases》2018年第1期32-35,共4页Jue Wang Huijie Zhang 
At present, malignant tumor is a serious threat to human health. Its pathogenesis is complicated and caused by the interaction of various carcinogenic factors in human body. Human sal-like protein 4 (SALL4) is a newly...
关键词：PROTO-ONCOGENE SALL4 TUMOR 
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