RECONSTITUTION

作品数：78被引量：86H指数：5
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Dendritic nanomedicine enhances chemoimmunotherapy by disturbing metabolism of cancer-associated fibroblasts for deep penetration and activating function of immune cells
《Acta Pharmaceutica Sinica B》2024年第8期3680-3696,共17页Yunkun Li Xiaoding Shen Haitao Ding Yuxin Zhang Dayi Pan Liping Su Yahui Wu Zaixiang Fang Jie Zhoua Qiyong Gong Kui Luo 
supported by the National Science and Technology Major Project of China(2023YFB3810004);the National Natural Science Foundation of China(32271445,52103175,32271382,32101145);the National Key Research and Development Program of China(2022YFC2009900);Department of Science and Technology of Sichuan Province(24NSFJQ0167,China);1·3·5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC21013,China);Post-Doctor Research Project,West China Hospital,Sichuan University(2021HXBH055,2021HXBH057,China);China Postdoctoral Science Foundation(2021M692314).
Inefficient drug penetration hurdled by the stroma in the tumor tissue leads to a diminished therapeutic effect for drugs and a reduced infiltration level of immune cells.Herein,we constructed a PEGylated dendritic ep...
关键词：Dendritic prodrug Enhanced penetration Metabolic intervention Cancer-associated fibroblasts Immunogenic cell death Chemotherapy Immunotherapy Immune microenvironment reconstitution 
Preparation of wood-based hydrogel membranes for efficient purification of complex wastewater using a reconstitution strategy
《Frontiers of Environmental Science & Engineering》2024年第7期59-72,共14页Qian He Junkai Gao Zhongzhi Chen Yuanjing Ding Mengsheng Xia Pengtao Xu Yan Chen 
This work was supported by the Zhejiang Provincial Natural Science Foundation of China(No.LY23D060004);the Science and Technology Planning Project of Zhoushan of China(No.2022C41005);the National Natural Science Foundation of China(No.51606168).
To avoid resource wastage and secondary environmental pollution,recycling and reusing waste wood powder is still a great challenge.Moreover,the poor viscosity and irregular pore size of wood powder limit its practical...
关键词：Wood powder Reconstitution strategy Hydrogel membrane RECYCLING WASTEWATER 
Reconstitution of double-negative T cells after cord blood transplantation and its predictive value for acute graft-versus-host disease被引量：1
《Chinese Medical Journal》2024年第10期1207-1217,共11页Tianzhong Pan Peng Ding Aijie Huang Baolin Tang Kaidi Song Guangyu Sun Yue Wu Shiying Yang Xingchi Chen Dongyao Wang Xiaoyu Zhu 
National Natural Science Foundation of China(Nos.82270223,82170209,and 82100230);Anhui Provincial Key Research and Development Project(No.2022e07020015);Anhui Health Research Project(No.AHWJ2022a 011);Fundamental Research Funds for the Central Universities(Nos.WK9110000204,and WK9110000168)
Background:With an increasing number of patients with hematological malignancies being treated with umbilical cord blood transplantation(UCBT),the correlation between immune reconstitution(IR)after UCBT and graft-vers...
关键词：Umbilical cord blood transplantation Graft-versus-host disease Immune reconstitution Double negative T Hematological Malignancies Treg cell Breg cell 
Identification of missing CYP450 enzymes involved in paclitaxel biosynthesis and heterologous reconstitution of baccatin III
《Chinese Journal of Natural Medicines》2024年第4期291-292,共2页DU Jinfa LIAO Pan LU Xu 
Paclitaxel,a tetracyclic diterpenoid,has garnered attention for its potent anti-cancer properties and intricate molecular structure,making it a significant target for chemical synthesis and biosynthesis[1].However,its...
关键词：Paclitaxel biosynthesis Baccatin III Cytochrome P450 Taxane oxetanase 1 Heterologous reconstitution 
Reform and Reconstitution of Core Courses in Mechanical and Electronic Engineering Under the Background of New Engineering
《Journal of Contemporary Educational Research》2023年第12期214-219,共6页Yali Yu Keyi Wang Yong Yang 
With the arrival of the intelligence era of Industry 4.0,social development has shown complex and diversified characteristics,gradually forming an innovation ecological environment constructed by vertical interaction ...
关键词：New engineering Mechanical and electronic engineering CROSS-COUPLING Major integration 
Evolutive Trend of Water Level in the Ebrie Lagoon by Reconstitution of the Tide Gauge Time Series in Front of the Abidjan Coastline (Côte d’Ivoire)
《Journal of Water Resource and Protection》2023年第10期526-538,共13页Samassy Rokyatou Yéo Kokoa Chia Marie Reine Allialy Tano Anoumou Rene Mondé Sylvain Sangaré Seydou Kouadio Affian 
The latest Intergovernmental Panel on Climate Change (IPCC) report shows that sea-level rise, which has been accelerated since the 19th century resulting to the global warming, threatens coastal areas with high popula...
关键词：TIDE Mean Water Level Temporal Variability Vridi Channel Marine Submersion 
Metformin may be a viable adjunctive therapeutic option to potentially enhance immune reconstitution in HIV-positive immunological non-responders
《Chinese Medical Journal》2023年第18期2147-2155,共9页Silvere D.Zaongo Yaokai Chen 
Chongqing Talent Cultivation Program(No.cstc2021ycjh-bgzxm0275);Key Project of the Chongqing Science&Technology Bureau(No.cstc2020jscx-cylhX0001)
Incomplete immune reconstitution remains a global challenge for human immunodeficiency virus(HIV)treatment in the present era of potent antiretroviral therapy(ART),especially for those individuals referred to as immun...
关键词：HIV Human immunodeficiency virus Immune reconstitution Immunological non-responders METFORMIN 
A robust method for identification of plant SUMOylation substrates in a library-based reconstitution system
《Plant Communications》2023年第4期1-4,共4页Ruiqiang Lai Wenliang Li Zewei Xu Wen Liu Qianrui Zeng Wenxiong Lin Jieming Jiang Jianbin Lai Chengwei Yang 
supported by the Major Program of Guangdong Basic and Applied Research(2019B030302006);the National Natural Science Foundation of China(32270292,32270752,and 31970531);the Natural Science Foundation of Guangdong(2019A1515110330,2018B030308002,and 2021A1515011151);the Program for Changjiang Scholars;and the Guangdong Special Support Program of Young Top-Notch Talent in Science and Technology Innovation(2019TQ05N651).
Dear Editor,SUMOylation,which transfers a small ubiquitin-like protein to the lysine residues of target proteins,is an important type of posttranslational modification in eukaryotic cells.This modification plays a cri...
关键词：SUMO1 SUMO hundreds 
Post Debarking Response of Prunus africana (Hook. F) Kalkman (Rosaceae) Trees at Two Exploitation Sites in North Kivu (Eastern Democratic Republic of Congo)
《Open Journal of Forestry》2023年第2期161-181,共21页Kambale Eloge Muhesi Musubao Moïse Kapiri Jean Lagarde Betti Ndongo Din 
Prunus africana is a species of great economic, medicinal and ecological importance. Due to its multiple uses, unsustainable exploitation methods and low regeneration capacity in tropical rainforests, this species is ...
关键词：Dendrometric Parameters Regeneration Capacity Tree Reconstitution Rate DEBARKING Prunus africana DR Congo 
The CXCR4-CXCL12 axis promotes T cell reconstitution via efficient hematopoietic immigration被引量：1
《Journal of Genetics and Genomics》2022年第12期1138-1150,共13页Fangying Zhao Yafang Lu Zhifan Li Jiangyong He Nianfei Cui Lingfei Luo Li Li 
supported by National Key Research and Development Project(2019YFA802703);National Natural Science Foundation of China Grants(331822033,31771623,32000568);Fundamental Research Funds for the Central Universities Grant(XDJK2020C041);Natural Science Foundation of Chongqing(CSTC2020JCYJMSXMX0104)。
T cells play a critical role in immunity to protect against pathogens and malignant cells.T cell immunodeficiency is detrimental,especially when T cell perturbation occurs during severe infection,irradiation,chemother...
关键词：T cell reconstitution IMMIGRATION Cxcr4b Cxcl12b ZEBRAFISH 
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